LAPATINIB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C29H26ClFN4O4S
Molecular Weight	581.058
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of LAPATINIB

Structure Search

SMILES

CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC=C3N=CN=C(NC4=CC=C(OCC5=CC=CC(F)=C5)C(Cl)=C4)C3=C2

InChI

InChIKey=BCFGMOOMADDAQU-UHFFFAOYSA-N

InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)

HIDE SMILES / InChI

Approval Year

Name

Type

Language

LAPATINIB

Official Name

English

LAPATINIB [EMA EPAR]

Common Name

English

lapatinib [INN]

Common Name

English

GSK-572016

Code

English

GW-572016X

Code

English

LAPATINIB [MI]

Common Name

English

GW572016

Code

English

LAPATINIB [VANDF]

Common Name

English

GW-572016

Code

English

Lapatinib [WHO-DD]

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000175605

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

NDF-RT

N0000175076

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

WHO-VATC

QL01XE07

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

NCI_THESAURUS

C155764

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

LIVERTOX

NBK547971

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

NCI_THESAURUS

C2167

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

NCI_THESAURUS

C129825

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

FDA ORPHAN DRUG

284209

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

WHO-ATC

L01XE07

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

Code System Code Type Description

SMS_ID

100000089379

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

ChEMBL

CHEMBL554

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

RXCUI

480167

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

RxNorm

LACTMED

Lapatinib

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

DRUG CENTRAL

1548

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

MESH

C490728

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

NSC

727989

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

PUBCHEM

208908

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

NCI_THESAURUS

C26653

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

DAILYMED

0VUA21238F

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

EVMPD

SUB25379

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

IUPHAR

5692

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

HSDB

8209

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

EPA CompTox

DTXSID7046675

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

MERCK INDEX

m6688

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

Merck Index

INN

8378

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

WIKIPEDIA

LAPATINIB

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

CAS

231277-92-2

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

DRUG BANK

DB01259

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

FDA UNII

0VUA21238F

Created by admin on Fri Dec 15 16:24:33 UTC 2023 , Edited by admin on Fri Dec 15 16:24:33 UTC 2023

PRIMARY

ACTIVE MOIETY


					0VUA21238F

LAPATINIB

METABOLITE (PARENT)


					2T859UZJ2V

2-FURANCARBOXYLIC ACID, 5-(4-((3-CHLORO-4-((3-FLUOROPHENYL)METHOXY)PHENYL)AMINO)-6-QUINAZOLINYL)-

METABOLITE (PARENT)


					E5KX9XN7KK

4-QUINAZOLINAMINE, N-(3-CHLORO-4-((3-FLUOROPHENYL)METHOXY)PHENYL)-6-(5-(((2-(METHYLSULFONYL)ETHYL)OXIDOIMINO)METHYL)-2-FURANYL)-

METABOLITE (PARENT)


					5T9BGR2UCX

2(1H)-QUINAZOLINONE, 4-((3-CHLORO-4-HYDROXYPHENYL)AMINO)-6-(5-(((2-(METHYLSULFONYL)ETHYL)AMINO)METHYL)-2-FURANYL)-

METABOLITE (PARENT)


					62B2FT6RF5

4-QUINAZOLINAMINE, N-(3-CHLORO-4-((3-FLUOROPHENYL)METHOXY)PHENYL)-6-(5-((HYDROXY(2-(METHYLSULFONYL)ETHYL)AMINO)METHYL)-2-FURANYL)-

METABOLITE (PARENT)


					7E8WRS38J2

6-(4-(3-CHLORO-4-((3-FLUOROPHENYL)METHOXY)ANILINO)QUINAZOLIN-6-YL)-1-(2-METHYLSULFONYLETHYL)PYRIDIN-1-IUM-3-OL

METABOLITE (PARENT)


					XA9X87F37H

(5-(4-(4-((3-FLUOROBENZYL)OXY)-3-CHLOROANILINO)-6-QUINAZOLINYL)-2-FURANCARBOXALDEHYDE

METABOLITE (PARENT)


					6MG3HT6C36

N-DEALKYLATED LAPATINIB

METABOLITE (PARENT)


					UA76LS94X4

4-QUINAZOLINAMINE, N-(3-CHLORO-4-((3-FLUOROPHENYL)METHOXY)PHENYL)-6-(5-(((2-(METHYLSULFONYL)ETHYLIDENE)OXIDOAMINO)METHYL)-2-FURANYL)-

METABOLITE TOXIC (PARENT)


					8PL9CEZ8WK

O-DEALKYLATED LAPATINIB

SALT/SOLVATE (PARENT)


					G873GX646R

LAPATINIB DITOSYLATE