REGORAFENIB ANHYDROUS

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H15ClF4N4O3
Molecular Weight	482.815
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of REGORAFENIB ANHYDROUS

Structure Search

SMILES

CNC(=O)C1=NC=CC(OC2=CC(F)=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2)=C1

InChI

InChIKey=FNHKPVJBJVTLMP-UHFFFAOYSA-N

InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)

HIDE SMILES / InChI

Approval Year

Name

Type

Language

REGORAFENIB ANHYDROUS

Common Name

English

4-(4-(((4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)CARBAMOYL)AMINO)-3-FLUOROPHENOXY)-N-METHYLPYRIDINE-2-CARBOXAMIDE

Systematic Name

English

BAY 73-4506

Code

English

Regorafenib [WHO-DD]

Common Name

English

BAY-734506

Code

English

REGORAFENIB [VANDF]

Common Name

English

regorafenib [INN]

Common Name

English

REGORAFENIB [MI]

Common Name

English

BAY-73-4506

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C1742

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

WHO-ATC

L01XE21

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

FDA ORPHAN DRUG

329410

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

NCI_THESAURUS

C1404

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

NCI_THESAURUS

C129825

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

LIVERTOX

839

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

EMA ASSESSMENT REPORTS

STIVARGA (AUTHORIZED: COLORECTAL NEOPLASMS)

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

FDA ORPHAN DRUG

690619

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

NDF-RT

N0000175605

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

WHO-VATC

QL01XE21

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

FDA ORPHAN DRUG

478015

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

Code System Code Type Description

SMS_ID

100000136039

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

CHEBI

68647

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

WIKIPEDIA

Regorafenib

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

CAS

755037-03-7

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

IUPHAR

5891

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

DRUG BANK

DB08896

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

FDA UNII

24T2A1DOYB

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

DAILYMED

24T2A1DOYB

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

LACTMED

Regorafenib

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

DRUG CENTRAL

4654

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

CHEBI

68646

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

EVMPD

SUB73090

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

NCI_THESAURUS

C78204

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

PUBCHEM

11167602

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

RXCUI

1312397

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

RxNorm

ChEMBL

CHEMBL1946170

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

MERCK INDEX

m11701

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

EPA CompTox

DTXSID60226441

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

MESH

C559147

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

NDF-RT

N0000185504

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

Cytochrome P450 2C9 Inhibitors [MoA]

INN

9026

Created by admin on Fri Dec 15 17:21:27 UTC 2023 , Edited by admin on Fri Dec 15 17:21:27 UTC 2023

PRIMARY

ACTIVE MOIETY


					24T2A1DOYB

REGORAFENIB ANHYDROUS

METABOLITE ACTIVE (PARENT)


					2JAO521NBP

N-DESMETHYL REGORAFENIB N-OXIDE

METABOLITE ACTIVE (PARENT)


					A56AQ8HGJ9

METABOLITE INACTIVE (PARENT)


					8DT73F5HD2

4-(4-((4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)CARBAMOYLAMINO)-3-FLUORO-PHENOXY)-N-(HYDROXYMETHYL)-1-OXIDO-PYRIDIN-1-IUM-2-CARBOXAMIDE

METABOLITE INACTIVE (PARENT)


					58I22S7HYD

METABOLITE INACTIVE (PARENT)


					ZU2HG2Y956

4-(4-((4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)CARBAMOYLAMINO)-3-FLUORO-PHENOXY)PYRIDINE-2-CARBOXYLIC ACID

METABOLITE INACTIVE (PARENT)


					6U6Y8H96HP

1-((4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)(((2-FLUORO-4-((2-((METHYLAMINO)CARBONYL)-1-OXIDO-4-PYRIDINYL)OXY)PHENYL)AMINO)CARBONYL)AMINO)-1-DEOXY-.BETA.-D-GLUCOPYRANURONIC ACID

METABOLITE INACTIVE (PARENT)


					4VV7F8M5U9

REGORAFENIB METABOLITE M7

SALT/SOLVATE (PARENT)


					MGN125FS9D