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Details

Stereochemistry ACHIRAL
Molecular Formula C26H23FIN5O4
Molecular Weight 615.3948
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRAMETINIB

SMILES

CN1C(=O)C(C)=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC4=CC=C(I)C=C4F)C5=CC(NC(C)=O)=CC=C5

InChI

InChIKey=LIRYPHYGHXZJBZ-UHFFFAOYSA-N
InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)

HIDE SMILES / InChI

Approval Year

Unknown
86413
Name Type Language
TRAMETINIB
DASH   INN   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
TRAMETINIB [MI]
Common Name English
Trametinib [WHO-DD]
Common Name English
JTP 74057
Code English
JTP-74057
Code English
TMT-212
Code English
TMT212
Code English
TRAMETINIB [VANDF]
Common Name English
N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide
Systematic Name English
TRAMETINIB [USAN]
Common Name English
GSK1120212
Code English
GSK-1120212
Code English
ACETAMIDE, N-(3-(3-CYCLOPROPYL-5-((2-FLUORO-4-IODOPHENYL)AMINO)-3,4,6,7-TETRAHYDRO-6,8- DIMETHYL-2,4,7-TRIOXOPYRIDO(4,3-D)PYRIMIDIN-1(2H)-YL)PHENYL)-
Systematic Name English
trametinib [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C69145
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
NCI_THESAURUS C129825
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
FDA ORPHAN DRUG 376812
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
WHO-ATC L01XE25
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
EMA ASSESSMENT REPORTS MEKINIST (AUTHORIZED: MELANOMA)
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
FDA ORPHAN DRUG 882722
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
FDA ORPHAN DRUG 495915
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
WHO-VATC QL01XE25
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
FDA ORPHAN DRUG 325410
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
FDA ORPHAN DRUG 521616
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
NDF-RT N0000175605
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
Code System Code Type Description
CHEBI
75998
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
WIKIPEDIA
TRAMETINIB
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
FDA UNII
33E86K87QN
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
SMS_ID
100000143251
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
EPA CompTox
DTXSID901007381
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
EVMPD
SUB119776
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
INN
9421
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
CHEBI
75991
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
DAILYMED
33E86K87QN
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
PUBCHEM
11707110
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
NCI_THESAURUS
C77908
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
LACTMED
Trametinib
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
DRUG CENTRAL
4802
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
MERCK INDEX
m11718
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
ChEMBL
CHEMBL2103875
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
DRUG BANK
DB08911
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
RXCUI
1425099
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY RxNorm
USAN
XX-79
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
IUPHAR
6495
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
CAS
871700-17-3
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
ACTIVE MOIETY
Structure of TRAMETINIB
METABOLITE ACTIVE (PARENT)
Structure of TRAMETINIB, DESACETYL
METABOLITE INACTIVE (PARENT)
Structure of DESACETYL TRAMETINIB N-GLUCORONIDE
SALT/SOLVATE (PARENT)
Structure of Trametinib acetate
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