OSIMERTINIB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C28H33N7O2
Molecular Weight	499.6073
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of OSIMERTINIB

Structure Search

SMILES

COC1=C(NC2=NC=CC(=N2)C3=CN(C)C4=CC=CC=C34)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C

InChI

InChIKey=DUYJMQONPNNFPI-UHFFFAOYSA-N

InChI=1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32)

HIDE SMILES / InChI

Approval Year

Name

Type

Language

OSIMERTINIB

Official Name

English

OSIMERTINIB [MI]

Common Name

English

osimertinib [INN]

Common Name

English

MERELETINIB

Official Name

English

Osimertinib [WHO-DD]

Common Name

English

OSIMERTINIB [USAN]

Common Name

English

2-PROPENAMIDE, N-(2-((2-(DIMETHYLAMINO)ETHYL)METHYLAMINO)-4-METHOXY-5-((4-(1-METHYL-1H-INDOL-3-YL)-2-PYRIMIDINYL)AMINO)PHENYL)-

Systematic Name

English

AZD9291

Code

English

AZD-9291

Code

English

AZD-9291 FREE BASE

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C129825

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

NDF-RT

N0000175605

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

FDA ORPHAN DRUG

445214

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

NCI_THESAURUS

C2167

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

WHO-ATC

L01XE35

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

Code System Code Type Description

ChEMBL

CHEMBL3353410

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

FDA UNII

3C06JJ0Z2O

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

DRUG BANK

DB09330

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

RXCUI

1721560

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

RxNorm

NDF-RT

N0000191266

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

Cytochrome P450 1A2 Inducers [MoA]

USAN

CD-52

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

INN

10043

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

NDF-RT

N0000175082

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

Kinase Inhibitors [MoA]

LACTMED

Osimertinib

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

NDF-RT

N0000190114

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

Cytochrome P450 3A Inhibitors [MoA]

NDF-RT

N0000185506

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

Cytochrome P450 3A4 Inducers [MoA]

CAS

1421373-65-0

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

WIKIPEDIA

OSIMERTINIB

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

DRUG CENTRAL

5062

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

CHEBI

90943

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

SMS_ID

100000162510

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

DAILYMED

3C06JJ0Z2O

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

NDF-RT

N0000190113

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

Breast Cancer Resistance Protein Inhibitors [MoA]

MERCK INDEX

m11906

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

NCI_THESAURUS

C116377

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

EPA CompTox

DTXSID501025961

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

EVMPD

SUB176340

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

PUBCHEM

71496458

Created by admin on Sat Dec 16 08:50:58 UTC 2023 , Edited by admin on Sat Dec 16 08:50:58 UTC 2023

PRIMARY

ACTIVE MOIETY


					3C06JJ0Z2O

METABOLITE (PARENT)


					9DD4NXS7RD

2-PROPENAMIDE, N-(2-((2-(DIMETHYLOXIDOAMINO)ETHYL)METHYLAMINO)-4-METHOXY-5-((4-(1-METHYL-1H-INDOL-3-YL)-2-PYRIMIDINYL)AMINO)PHENYL)-

METABOLITE (PARENT)


					X436A98JWG

N-Hydroxy-osimertinib

METABOLITE (PARENT)


					BCQ0XF3C37

N-(4-METHOXY-2-(METHYLAMINO)-5-((4-(1-METHYLINDOL-3-YL)PYRIMIDIN-2-YL)AMINO)PHENYL)PROP-2-ENAMIDE

METABOLITE (PARENT)


					2DWZ6SE1E1

AZ-5104

METABOLITE (PARENT)


					NL4G273UPN

(2R)-2-AMINO-3-(3-(2-(2-DIMETHYLAMINOETHYL(METHYL)AMINO)-4-METHOXY-5-((4-(1-METHYLINDOL-3-YL)PYRIMIDIN-2-YL)AMINO)ANILINO)-3-OXO-PROPYL)SULFANYL-PROPANOIC ACID

METABOLITE ACTIVE (PARENT)


					NI2ZUZ6F4O

AZ-7550

SALT/SOLVATE (PARENT)


					RDL94R2A16

OSIMERTINIB MESYLATE