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Details

Stereochemistry ABSOLUTE
Molecular Formula C24H25ClFN5O3
Molecular Weight 485.938
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of AFATINIB

SMILES

CN(C)C\C=C\C(=O)NC1=CC2=C(C=C1O[C@H]3CCOC3)N=CN=C2NC4=CC(Cl)=C(F)C=C4

InChI

InChIKey=ULXXDDBFHOBEHA-CWDCEQMOSA-N
InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1

HIDE SMILES / InChI

Approval Year

Unknown
86413
Name Type Language
AFATINIB
DASH   INN   MART.   MI   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
Afatinib [WHO-DD]
Common Name English
AFATINIB [MI]
Common Name English
TOVOK
Brand Name English
AFATINIB [USAN]
Common Name English
BIBW 2992
Common Name English
AFATINIB [VANDF]
Common Name English
(2E)-N-(4-(3-CHLORO-4-FLUOROANILINO)-7-(((3S)-OXOLAN-3-YL)OXY)QUINOXAZOLIN-6-YL)-4-(DIMETHYLAMINO)BUT-2-ENAMIDE
Common Name English
TOMTOVOK
Brand Name English
BIBW2992
Code English
afatinib [INN]
Common Name English
BIBW-2992
Code English
AFATINIB [MART.]
Common Name English
NSC-750691
Code English
2-BUTENAMIDE, N-(4-((3-CHLORO-4-FLUOROPHENYL)AMINO)-7-(((3S)-TETRAHYDRO-3-FURANYL)OXY)- 6-QUINAZOLINYL)-4-(DIMETHYLAMINO)-, (2E)-
Common Name English
Classification Tree Code System Code
NDF-RT N0000175605
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
WHO-VATC QL01XE13
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
WHO-ATC L01XE13
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
FDA ORPHAN DRUG 484115
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
NCI_THESAURUS C2167
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
EU-Orphan Drug EU/3/18/2110
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
EMA ASSESSMENT REPORTS GIOTRIF(AUTHORIZED: CARCINOMA, NON-SMALL-CELL LUNG)
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
FDA ORPHAN DRUG 375712
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
FDA ORPHAN DRUG 690419
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
FDA ORPHAN DRUG 433414
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
FDA ORPHAN DRUG 781420
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
NCI_THESAURUS C129825
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
Code System Code Type Description
CAS
439081-18-2
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
NON-SPECIFIC STEREOCHEMISTRY
WIKIPEDIA
AFATINIB
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY
PUBCHEM
10184653
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY
DRUG BANK
DB08916
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY
NSC
750691
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY
NCI_THESAURUS
C66940
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY
FDA UNII
41UD74L59M
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY
ChEMBL
CHEMBL1173655
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY
MERCK INDEX
m1439
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY Merck Index
SMS_ID
100000124505
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY
CHEBI
61390
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY
CAS
850140-72-6
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY
DAILYMED
41UD74L59M
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY
RXCUI
1430438
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY RxNorm
INN
9230
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY
EPA CompTox
DTXSID20893451
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY
EVMPD
SUB32268
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY
DRUG CENTRAL
4318
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY
USAN
YY-16
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY
IUPHAR
5667
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY
LACTMED
Afatinib
Created by admin on Fri Dec 15 17:25:09 UTC 2023 , Edited by admin on Fri Dec 15 17:25:09 UTC 2023
PRIMARY
ACTIVE MOIETY
Structure of AFATINIB
METABOLITE (PARENT)
Structure of AFATINIB N-OXIDE
METABOLITE LESS ACTIVE (PARENT)
Structure of N-DESMETHYL AFATINIB
SALT/SOLVATE (PARENT)
Structure of AFATINIB DIMALEATE
NIH
NCATS
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ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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