NINTEDANIB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C31H33N5O4
Molecular Weight	539.6248
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of NINTEDANIB

Structure Search

SMILES

COC(=O)C1=CC2=C(C=C1)\C(C(=O)N2)=C(\NC3=CC=C(C=C3)N(C)C(=O)CN4CCN(C)CC4)C5=CC=CC=C5

InChI

InChIKey=XZXHXSATPCNXJR-ZIADKAODSA-N

InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-

HIDE SMILES / InChI

Approval Year

Name

Type

Language

NINTEDANIB

Official Name

English

BIBF1120

Code

English

INTEDANIB

Common Name

English

BIBF 1120

Code

English

NINTEDANIB COMPONENT OF OFEV

Brand Name

English

Methyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate

Systematic Name

English

Nintedanib [WHO-DD]

Common Name

English

NINTEDANIB [VANDF]

Common Name

English

NINTEDANIB [USAN]

Common Name

English

INTEDANIB [MI]

Common Name

English

BIBF-1120

Code

English

OFEV COMPONENT NINTEDANIB

Brand Name

English

nintedanib [INN]

Common Name

English

VARGATEF

Brand Name

English

Classification Tree Code System Code

EMA ASSESSMENT REPORTS

OFEV (AUTHORISED: IDIOPATHIC PULMONARY FIBROSIS)

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

FDA ORPHAN DRUG

344511

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

WHO-ATC

L01XE31

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

EU-Orphan Drug

EU/3/16/1724

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

FDA ORPHAN DRUG

547916

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

NCI_THESAURUS

C1742

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

NCI_THESAURUS

C155727

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

FDA ORPHAN DRUG

528516

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

NDF-RT

N0000175605

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

Code System Code Type Description

DAILYMED

G6HRD2P839

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

PRIMARY

EVMPD

SUB120728

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

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MERCK INDEX

m6301

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

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Merck Index

DRUG CENTRAL

4903

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

PRIMARY

MESH

C530716

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

PRIMARY

USAN

ZZ-49

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

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LACTMED

Nintedanib

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

PRIMARY

CAS

656247-17-5

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

PRIMARY

CHEBI

85164

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

PRIMARY

ChEMBL

CHEMBL502835

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

PRIMARY

IUPHAR

5936

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

PRIMARY

DRUG BANK

DB09079

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

PRIMARY

RXCUI

1592737

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

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RxNorm

HSDB

8339

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

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FDA UNII

G6HRD2P839

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

PRIMARY

NCI_THESAURUS

C62765

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

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PUBCHEM

9809715

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

PRIMARY

EPA CompTox

DTXSID201025948

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

PRIMARY

SMS_ID

100000144000

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

PRIMARY

INN

9229

Created by admin on Fri Dec 15 16:40:47 UTC 2023 , Edited by admin on Fri Dec 15 16:40:47 UTC 2023

PRIMARY

ACTIVE MOIETY


					G6HRD2P839

METABOLITE (PARENT)


					GZ544M4ZP6

(3Z)-3-((4-(METHYL-(2-PIPERAZIN-1-YLACETYL)AMINO)ANILINO)-PHENYL-METHYLENE)-2-OXO-INDOLINE-6-CARBOXYLIC ACID

METABOLITE (PARENT)


					LW8QB286HN

BIBF-1202

METABOLITE (PARENT)


					3TK2E45UHG

1H-INDOLE-6-CARBOXYLIC ACID, 2,3-DIHYDRO-3-(((4-(METHYL(2-(1-PIPERAZINYL)ACETYL)AMINO)PHENYL)AMINO)PHENYLMETHYLENE)-2-OXO-, METHYL ESTER, (3Z)-

SALT/SOLVATE (PARENT)


					23O68KB9KV

NINTEDANIB ESYLATE HEMIHYDRATE

SALT/SOLVATE (PARENT)


					42F62RTZ4G

NINTEDANIB ESYLATE