ADAVOSERTIB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C27H32N8O2
Molecular Weight	500.5954
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ADAVOSERTIB

Structure Search

SMILES

CN1CCN(CC1)C2=CC=C(NC3=NC=C4C(=O)N(CC=C)N(C4=N3)C5=NC(=CC=C5)C(C)(C)O)C=C2

InChI

InChIKey=BKWJAKQVGHWELA-UHFFFAOYSA-N

InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,18,37H,1,13-17H2,2-4H3,(H,28,29,31)

HIDE SMILES / InChI

Approval Year

Name

Type

Language

ADAVOSERTIB

Official Name

English

1,2-DIHYDRO-1-(6-(1-HYDROXY-1-METHYLETHYL)-2-PYRIDINYL)-6-((4-(4-METHYL-1-PIPERAZINYL)PHENYL)AMINO)-2-(2-PROPEN-1-YL)-3H-PYRAZOLO(3,4-D)PYRIMIDIN-3-ONE

Systematic Name

English

1-[6-(2-Hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one

Systematic Name

English

ADAVOSERTIB [USAN]

Common Name

English

3H-PYRAZOLO(3,4-D)PYRIMIDIN-3-ONE, 1,2-DIHYDRO-1-(6-(1-HYDROXY-1-METHYLETHYL)-2-PYRIDINYL)-6-((4-(4-METHYL-1-PIPERAZINYL)PHENYL)AMINO)-2-(2-PROPEN-1-YL)-

Systematic Name

English

MK-1775

Code

English

MK1775

Code

English

AZD-1775

Code

English

adavosertib [INN]

Common Name

English

Adavosertib [WHO-DD]

Common Name

English

AZD1775

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C1967

Created by admin on Fri Dec 15 15:31:35 UTC 2023 , Edited by admin on Fri Dec 15 15:31:35 UTC 2023

Code System Code Type Description

USAN

FG-33

Created by admin on Fri Dec 15 15:31:35 UTC 2023 , Edited by admin on Fri Dec 15 15:31:35 UTC 2023

PRIMARY

PUBCHEM

24856436

Created by admin on Fri Dec 15 15:31:35 UTC 2023 , Edited by admin on Fri Dec 15 15:31:35 UTC 2023

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DRUG BANK

DB11740

Created by admin on Fri Dec 15 15:31:35 UTC 2023 , Edited by admin on Fri Dec 15 15:31:35 UTC 2023

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CAS

955365-80-7

Created by admin on Fri Dec 15 15:31:35 UTC 2023 , Edited by admin on Fri Dec 15 15:31:35 UTC 2023

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EU-Orphan Drug

EU/3/12/989(POSITIVE)

Created by admin on Fri Dec 15 15:31:35 UTC 2023 , Edited by admin on Fri Dec 15 15:31:35 UTC 2023

PRIMARY

treatment of ovarian cancer

NCI_THESAURUS

C91725

Created by admin on Fri Dec 15 15:31:35 UTC 2023 , Edited by admin on Fri Dec 15 15:31:35 UTC 2023

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SMS_ID

100000177968

Created by admin on Fri Dec 15 15:31:35 UTC 2023 , Edited by admin on Fri Dec 15 15:31:35 UTC 2023

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ChEMBL

CHEMBL1976040

Created by admin on Fri Dec 15 15:31:35 UTC 2023 , Edited by admin on Fri Dec 15 15:31:35 UTC 2023

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WIKIPEDIA

Adavosertib

Created by admin on Fri Dec 15 15:31:35 UTC 2023 , Edited by admin on Fri Dec 15 15:31:35 UTC 2023

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FDA UNII

K2T6HJX3I3

Created by admin on Fri Dec 15 15:31:35 UTC 2023 , Edited by admin on Fri Dec 15 15:31:35 UTC 2023

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INN

10667

Created by admin on Fri Dec 15 15:31:35 UTC 2023 , Edited by admin on Fri Dec 15 15:31:35 UTC 2023

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EPA CompTox

DTXSID30241868

Created by admin on Fri Dec 15 15:31:35 UTC 2023 , Edited by admin on Fri Dec 15 15:31:35 UTC 2023

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ACTIVE MOIETY


					K2T6HJX3I3

SALT/SOLVATE (PARENT)


					NDV91627P9

ADAVOSERTIB HEMIHYDRATE