Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H27FN4O2.C4H6O5 |
| Molecular Weight | 532.5612 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O[C@@H](CC(O)=O)C(O)=O.CCN(CC)CCNC(=O)C1=C(C)NC(\C=C2/C(=O)NC3=C2C=C(F)C=C3)=C1C
InChI
InChIKey=LBWFXVZLPYTWQI-IPOVEDGCSA-N
InChI=1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28;5-2(4(8)9)1-3(6)7/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28);2,5H,1H2,(H,6,7)(H,8,9)/b17-12-;/t;2-/m.0/s1
Approval Year
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C129825
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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EMA ASSESSMENT REPORTS |
SUTENT (AUTHORIZED: CARCINOMA , RENAL CELL)
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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EMA ASSESSMENT REPORTS |
SUTENT (AUTHORIZED: GASTROINTESTINAL STROMAL TUMORS)
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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NCI_THESAURUS |
C1967
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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NCI_THESAURUS |
C1971
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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LVX8N1UT73
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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PRIMARY | |||
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1642358
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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PRIMARY | |||
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341031-54-7
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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PRIMARY | |||
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DBSALT000166
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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PRIMARY | |||
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616275
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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PRIMARY | RxNorm | ||
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C26673
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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PRIMARY | |||
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LVX8N1UT73
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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PRIMARY | |||
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6456015
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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PRIMARY | |||
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SUB22366
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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PRIMARY | |||
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EU/3/05/268(WITHDRAWN)
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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PRIMARY | Please note that this product was withdrawn from the Community Register of designated orphan medicinal products in July 2008 on request of the sponsor. On 10 March 2005, orphan designation (EU/3/05/268) was granted by the European Commission to Pfizer Limited, United Kingdom, for (Z)-N-[2-(diethylamino)ethyl]-5-[(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (S)-2-hydroxysyccinate for the treatment of renal cell carcinoma. (Z)-N-[2-(diethylamino)ethyl]-5-[(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (S)-2-hydroxysyccinate has been authorised in the EU as Sutent since 19 July 2006 for the treatment of advanced and/or metastatic renal cell carcinoma (MRCC) after failure of interferon alfa or interleukin-2 therapy. | ||
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EU/3/05/267(WITHDRAWN)
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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PRIMARY | Please note that this product was withdrawn from the Community Register of designated orphan medicinal products in July 2008 on request of the sponsor. On 10 March 2005, orphan designation (EU/3/05/267) was granted by the European Commission to Pfizer Limited, United Kingdom, for (Z)-N-[2-(diethylamino)ethyl]-5-[(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (S)-2-hydroxysyccinate for the treatment of malignant gastrointestinal stromal tumours. (Z)-N-[2-(Diethylamino)ethyl]-5-[(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (S)-2-hydroxysyccinate has been authorised in the EU as Sutent since 19 July 2006. | ||
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DTXSID4046492
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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PRIMARY | |||
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100000093454
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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PRIMARY | |||
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CHEMBL535
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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PRIMARY | |||
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QQ-94
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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PRIMARY | |||
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38940
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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PRIMARY | |||
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m10399
Created by
admin on Fri Dec 15 16:21:42 UTC 2023 , Edited by admin on Fri Dec 15 16:21:42 UTC 2023
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PRIMARY | Merck Index |
ACTIVE MOIETY
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
