Milademetan

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C30H34Cl2FN5O4
Molecular Weight	618.526
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1(C)CCC2(CC1)N[C@H]([C@H](C3=C(F)C(Cl)=NC=C3)[C@]24C(=O)NC5=C4C=CC(Cl)=C5)C(=O)N[C@@H]6CC[C@H](OC6)C(N)=O

InChI

InChIKey=RYAYYVTWKAOAJF-QISPRATLSA-N

InChI=1S/C30H34Cl2FN5O4/c1-28(2)8-10-29(11-9-28)30(18-5-3-15(31)13-19(18)37-27(30)41)21(17-7-12-35-24(32)22(17)33)23(38-29)26(40)36-16-4-6-20(25(34)39)42-14-16/h3,5,7,12-13,16,20-21,23,38H,4,6,8-11,14H2,1-2H3,(H2,34,39)(H,36,40)(H,37,41)/t16-,20+,21+,23-,30-/m1/s1

HIDE SMILES / InChI

Approval Year

Name

Type

Language

Milademetan

Official Name

English

(3′R,4′S,5′R)-N-[(3R,6S)-6-carbamoyloxan-3-yl]-6′′-chloro-4′-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2′′-oxo-1′′,2′′-dihydrodispiro[cyclohexane-1,2′-pyrrolidine-3′,3′′-indole]-5′-carboxamide

Systematic Name

English

MDM2 INHIBITOR DS-3032

Common Name

English

MILADEMETAN [USAN]

Common Name

English

L-erythro-Hexonamide, 2,6-anhydro-5-[[[(3′R,4′S,5′R)-6′′-chloro-4′-(2-chloro-3-fluoro-4-pyridinyl)-1′′,2′′-dihydro-4,4-dimethyl-2′′-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3′′-[3H]indol]-5′-yl]carbonyl]amino]-3,4,5-tr

Systematic Name

English

DS-3032

Code

English

milademetan [INN]

Common Name

English

Milademetan [WHO-DD]

Common Name

English

2,6-ANHYDRO-5-((((3'R,4'S,5'R)-6''-CHLORO-4'-(2-CHLORO-3-FLUORO-4-PYRIDINYL)-1'',2''-DIHYDRO-4,4-DIMETHYL-2''-OXODISPIRO(CYCLOHEXANE-1,2'-PYRROLIDINE-3',3''-(3H)INDOL)-5'-YL)CARBONYL)AMINO)-3,4,5-TRIDEOXY-L-ERYTHRO-HEXONAMIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C129839