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Details

Stereochemistry ABSOLUTE
Molecular Formula 2C22H24N2O8.C2H6O.2ClH.H2O
Molecular Weight 1025.875
Optical Activity UNSPECIFIED
Defined Stereocenters 12 / 12
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DOXYCYCLINE HYCLATE

SMILES

O.Cl.Cl.CCO.[H][C@@]12[C@@H](C)C3=CC=CC(O)=C3C(=O)C1=C(O)[C@]4(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]4([H])[C@H]2O.[H][C@@]56[C@@H](C)C7=CC=CC(O)=C7C(=O)C5=C(O)[C@]8(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]8([H])[C@H]6O

InChI

InChIKey=HALQELOKLVRWRI-VDBOFHIQSA-N
InChI=1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;2*1H;1H2/t2*7-,10+,14+,15-,17-,22-;;;;/m00..../s1

HIDE SMILES / InChI
Molecular Formula C22H24N2O8
Molecular Weight 444.4346
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 5 / 6
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula C2H6O
Molecular Weight 46.0684
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:19:34 UTC 2023
Edited
by admin
on Fri Dec 15 15:19:34 UTC 2023
Record UNII
19XTS3T51U
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DOXYCYCLINE HYCLATE
EP   GREEN BOOK   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
Common Name English
NSC-741421
Code English
ZADORIN
Brand Name English
DOXY
Brand Name English
DURADOXAL
Brand Name English
DOXYCYCLINE HYCLATE [ORANGE BOOK]
Common Name English
VIBRA-TABS
Brand Name English
AZUDOXAT
Brand Name English
SPANOR
Brand Name English
CLINOFUG
Brand Name English
ACTICLATE
Brand Name English
DOXYCYCLINE HYDROCHLORIDE HEMIETHANOLATE HEMIHYDRATE [MI]
Common Name English
DOXYCYCLINE HYDROCHLORIDE HYDRATE [JAN]
Common Name English
DOXYCYCLINI HYCLAS [WHO-IP LATIN]
Common Name English
MONODOKS
Common Name English
VIBRAVENOS
Brand Name English
DOXYCYCLINE HYCLATE [VANDF]
Common Name English
DOXYCYCLINE HYCLATE [EP IMPURITY]
Common Name English
DOXYCYCLINE HYCLATE [WHO-IP]
Common Name English
DOXYCYCLINE HYCLATE [EP MONOGRAPH]
Common Name English
DOXYCYCLINE HYCLATE [USP-RS]
Common Name English
MESPAFIN
Brand Name English
DIOCIMEX
Brand Name English
TETRACLEAN
Common Name English
LYMEPAK
Brand Name English
VIBRAMYCIN
Brand Name English
ACTICLATE CAP
Brand Name English
DORYX
Brand Name English
RETENS
Brand Name English
DOXYLAR
Brand Name English
GRANUDOXY
Brand Name English
RONAXAN
Brand Name English
DOXICRISOL
Brand Name English
DOXYCYCLINE HYCLATE [USP MONOGRAPH]
Common Name English
PERIOSTAT
Brand Name English
4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride, compound with ethyl alcohol (2:1), monohydrate
Common Name English
TETRADOX
Brand Name English
DOXYCYCLINE HYDROCHLORIDE HEMIETHANOLATE HEMIHYDRATE
MI  
Common Name English
ATRIDOX
Brand Name English
DOXYCYCLINE HYCLATE [GREEN BOOK]
Common Name English
DOXYPREX
Common Name English
DOXY-LEMMON
Brand Name English
DOXYCHEL HYCLATE
Brand Name English
VIBRAVEINEUSE
Brand Name English
Doxycycline hyclate [WHO-DD]
Common Name English
UNACIL
Brand Name English
Classification Tree Code System Code
NCI_THESAURUS C1595
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
CFR 21 CFR 522.778
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
EU-Orphan Drug EU/3/12/955
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
Code System Code Type Description
RXCUI
23663
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
PRIMARY RxNorm
MERCK INDEX
m4758
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
PRIMARY Merck Index
EVMPD
SUB01830MIG
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
PRIMARY
NCI_THESAURUS
C29007
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
PRIMARY
SMS_ID
100000092638
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
PRIMARY
DAILYMED
19XTS3T51U
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
PRIMARY
CHEBI
50845
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
PRIMARY
CHEBI
34730
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
PRIMARY
FDA UNII
19XTS3T51U
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
PRIMARY
NSC
741421
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
PRIMARY
EPA CompTox
DTXSID4041020
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
PRIMARY
RS_ITEM_NUM
1226003
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
PRIMARY
DRUG BANK
DBSALT000896
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
PRIMARY
CAS
24390-14-5
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
PRIMARY
ChEMBL
CHEMBL1433
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
DOXYCYCLINE HYCLATE
Created by admin on Fri Dec 15 15:19:34 UTC 2023 , Edited by admin on Fri Dec 15 15:19:34 UTC 2023
PRIMARY Description: A yellow, crystalline powder.Solubility: Soluble in 3 parts of water and in 4 parts of methanol R; practically insoluble in ether R.Category: Antibacterial and antimalarial drug.Storage: Doxycycline hyclate should be kept in a tightly closed container, protected from light.Additional information: Even in the absence of light, Doxycycline hyclate is gradually degraded on exposure to a humid atmosphere, the decomposition being faster at higher temperatures.Requirements: Definition. Doxycycline hyclate contains not less than 95% and not more than 102% of C22H24N2O8,HCl, calculated with reference to the anhydrous and ethanol-free substance.
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BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
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Structure of DOXYCYCLINE ANHYDROUS
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Tmax PHARMACOKINETIC SUBGINGIVAL, CONTROLLED-RELEASE: 2 HOURS

ORAL, IMMEDIATE-RELEASE: 2 - 3 HOURS

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