RABEPRAZOLE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H21N3O3S
Molecular Weight	359.443
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of RABEPRAZOLE

Structure Search

SMILES

COCCCOC1=CC=NC(C[S+]([O-])C2=NC3=C(N2)C=CC=C3)=C1C

InChI

InChIKey=YREYEVIYCVEVJK-UHFFFAOYSA-N

InChI=1S/C18H21N3O3S/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21)

HIDE SMILES / InChI

Molecular Formula	C18H21N3O3S
Molecular Weight	359.443
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:44:20 UTC 2023` Edited by `admin` on `Fri Dec 15 15:44:20 UTC 2023`
Record UNII	32828355LL
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

RABEPRAZOLE

Official Name

English

LY-307640

Code

English

E-3810 (PPI)

Code

English

1H-BENZIMIDAZOLE, 2-(((4-(3-METHOXYPROPOXY)-3-METHYL-2-PYRIDINYL)METHYL)SULFINYL)-

Systematic Name

English

E3810

Code

English

rabeprazole [INN]

Common Name

English

LY307640

Code

English

RABEPRAZOLE [VANDF]

Common Name

English

RABEPRAZOLE [MI]

Common Name

English

PARIPRAZOLE

Common Name

English

Rabeprazole [WHO-DD]

Common Name

English

ERALOC

Brand Name

English

RABEPRAZOLE [HSDB]

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000175525

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

LIVERTOX

NBK548154

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

WHO-ATC

A02BC54

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

NDF-RT

N0000000147

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

WHO-ATC

A02BC04

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

WHO-VATC

QA02BC04

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

NCI_THESAURUS

C29723

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

Code System Code Type Description

EVMPD

SUB10229MIG

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

EPA CompTox

DTXSID3044122

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

INN

7112

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

SMS_ID

100000080304

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

LACTMED

Rabeprazole

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

IUPHAR

7290

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

MESH

C063129

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

DRUG BANK

DB01129

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

WIKIPEDIA

RABEPRAZOLE

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

CHEBI

8768

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

CAS

117976-89-3

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

PUBCHEM

5029

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

HSDB

7321

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

MERCK INDEX

m9476

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

Merck Index

NCI_THESAURUS

C29410

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

RXCUI

114979

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

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RxNorm

DAILYMED

32828355LL

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

DRUG CENTRAL

2350

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

ChEMBL

CHEMBL1219

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

FDA UNII

32828355LL

Created by admin on Fri Dec 15 15:44:20 UTC 2023 , Edited by admin on Fri Dec 15 15:44:20 UTC 2023

PRIMARY

Related Record Type Details


					5XH0X84AHJ

RABEPRAZOLE SODIUM MONOHYDRATE

SALT/SOLVATE -> PARENT

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					E2UJ1FS3EI

POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 1

TARGET -> INHIBITOR

Amount:


					65JK8810RM

ENANTIOMER -> RACEMATE

Amount:


					3L36P16U4R

RABEPRAZOLE SODIUM

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					I2E100O20P

RABEPRAZOLE SULFONE

METABOLITE -> PARENT

Interaction Type:

MAJOR

Amount:


					60DBG5I1US

DESMETHYL RABEPRAZOLE THIOETHER

METABOLITE ACTIVE -> PARENT

Amount:


					UY7YAG8252

RABEPRAZOLE METABOLITE ACTIVE SULFENIC ACID

METABOLITE ACTIVE -> PRODRUG

Amount:


					I58UIQ1OYK

DESMETHYL RABEPRAZOLE

METABOLITE -> PARENT

Amount:


					304S7E320P

RABEPRAZOLE THIOETHER

METABOLITE ACTIVE -> PARENT

Comments:

reduced mainly via a non-enzymatic pathway to thioether-rabeprazole (thioether-RPZ), with only minor CYP2C19 and CYP3A4 involvement

Interaction Type:

MAJOR

Amount:


					7J2FWA5FNK

3-(3-METHOXYPROPOXY)-4-METHYL-5H-PYRIDO(1',2':4,5)(1,2,4)THIADIAZINO(2,3-A)BENZIMIDAZOL-13-IUM

METABOLITE ACTIVE -> PRODRUG

Amount:

Related Record Type Details


					W8TD8KJ9XR

RABEPRAZOLE PICOLINIUM

IMPURITY -> PARENT

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC