CEDAZURIDINE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C9H14F2N2O5
Molecular Weight	268.2147
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CEDAZURIDINE

Structure Search

SMILES

OC[C@H]1O[C@@H](N2CC[C@@H](O)NC2=O)C(F)(F)[C@@H]1O

InChI

InChIKey=VUDZSIYXZUYWSC-DBRKOABJSA-N

InChI=1S/C9H14F2N2O5/c10-9(11)6(16)4(3-14)18-7(9)13-2-1-5(15)12-8(13)17/h4-7,14-16H,1-3H2,(H,12,17)/t4-,5-,6-,7-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C9H14F2N2O5
Molecular Weight	268.2147
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 14:31:29 UTC 2023` Edited by `admin` on `Sat Dec 16 14:31:29 UTC 2023`
Record UNII	39IS23Q1EW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CEDAZURIDINE

Official Name

English

CEDAZURIDINE [USAN]

Common Name

English

(4R)-2'-DEOXY-2',2'-DIFLUORO-3,4,5,6-TETRAHYDROURIDINE

Systematic Name

English

URIDINE, 2'-DEOXY-2',2'-DIFLUORO-3,4,5,6-TETRAHYDRO-, (4R)-

Systematic Name

English

Cedazuridine [WHO-DD]

Common Name

English

CEDAZURIDINE [ORANGE BOOK]

Common Name

English

CEDAZURIDINE COMPONENT OF INQOVI

Brand Name

English

E-7727

Code

English

INQOVI COMPONENT CEDAZURIDINE

Brand Name

English

ASTX-727 COMPONENT CEDAZURIDINE

Code

English

E7727

Code

English

ASTX727 COMPONENT CEDAZURIDINE

Code

English

cedazuridine [INN]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

697019

Created by admin on Sat Dec 16 14:31:29 UTC 2023 , Edited by admin on Sat Dec 16 14:31:29 UTC 2023

Code System Code Type Description

USAN

GH-142

Created by admin on Sat Dec 16 14:31:29 UTC 2023 , Edited by admin on Sat Dec 16 14:31:29 UTC 2023

PRIMARY

PUBCHEM

25267009

Created by admin on Sat Dec 16 14:31:29 UTC 2023 , Edited by admin on Sat Dec 16 14:31:29 UTC 2023

PRIMARY

INN

10741

Created by admin on Sat Dec 16 14:31:29 UTC 2023 , Edited by admin on Sat Dec 16 14:31:29 UTC 2023

PRIMARY

CAS

1141397-80-9

Created by admin on Sat Dec 16 14:31:29 UTC 2023 , Edited by admin on Sat Dec 16 14:31:29 UTC 2023

PRIMARY

SMS_ID

100000181098

Created by admin on Sat Dec 16 14:31:29 UTC 2023 , Edited by admin on Sat Dec 16 14:31:29 UTC 2023

PRIMARY

NCI_THESAURUS

C164146

Created by admin on Sat Dec 16 14:31:29 UTC 2023 , Edited by admin on Sat Dec 16 14:31:29 UTC 2023

PRIMARY

FDA UNII

39IS23Q1EW

Created by admin on Sat Dec 16 14:31:29 UTC 2023 , Edited by admin on Sat Dec 16 14:31:29 UTC 2023

PRIMARY

RXCUI

2384449

Created by admin on Sat Dec 16 14:31:29 UTC 2023 , Edited by admin on Sat Dec 16 14:31:29 UTC 2023

PRIMARY

DAILYMED

39IS23Q1EW

Created by admin on Sat Dec 16 14:31:29 UTC 2023 , Edited by admin on Sat Dec 16 14:31:29 UTC 2023

PRIMARY

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PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					39IS23Q1EW

EXCRETED UNCHANGED

Comments:

After oral administration of [14C]-cedazuridine, 17.1% (range, 12.0% to 24.1%) of the administered dose was excreted in the urine as unchanged cedazuridine within 75 hours.

Qualification:

URINE

Amount:


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Cytidine deaminase

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					39IS23Q1EW

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC				ONCE DAILY AT STEADY-STATE ORAL ADMINISTRATION

Tmax	PHARMACOKINETIC				ONCE DAILY ORAL ADMINISTRATION

ORAL BIOAVAILABILITY	PHARMACOKINETIC