RALTEGRAVIR POTASSIUM

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NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H20FN6O5.K
Molecular Weight	482.5067
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of RALTEGRAVIR POTASSIUM

Structure Search

SMILES

[K+].CN1C(=O)C([O-])=C(N=C1C(C)(C)NC(=O)C2=NN=C(C)O2)C(=O)NCC3=CC=C(F)C=C3

InChI

InChIKey=IFUKBHBISRAZTF-UHFFFAOYSA-M

InChI=1S/C20H21FN6O5.K/c1-10-25-26-17(32-10)16(30)24-20(2,3)19-23-13(14(28)18(31)27(19)4)15(29)22-9-11-5-7-12(21)8-6-11;/h5-8,28H,9H2,1-4H3,(H,22,29)(H,24,30);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	C20H20FN6O5
Molecular Weight	443.4084
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	K
Molecular Weight	39.0983
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:00:01 UTC 2023` Edited by `admin` on `Fri Dec 15 16:00:01 UTC 2023`
Record UNII	43Y000U234
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RALTEGRAVIR POTASSIUM

Official Name

English

MK-0518 POTASSIUM

Code

English

MK0518 POTASSIUM

Code

English

Potassium 4-[(4-fluorobenzyl)carbamoyl]-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo-1,6-dihydropyrimidin-5-olate

Systematic Name

English

4-PYRIMIDINECARBOXAMIDE, N-((4-FLUOROPHENYL)METHYL)-1,6-DIHYDRO-5-HYDROXY-1-METHYL-2-(1-METHYL-1-(((5-METHYL-1,3,4-OXADIAZOL-2-YL)CARBONYL)AMINO)ETHYL)-6-OXO-, MONOPOTASSIUM SALT

Common Name

English

RALTEGRAVIR POTASSIUM [JAN]

Common Name

English

RALTEGRAVIR POTASSIUM [ORANGE BOOK]

Common Name

English

RALTEGRAVIR POTASSIUM [USP MONOGRAPH]

Common Name

English

RALTEGRAVIR POTASSIUM [USAN]

Common Name

English

RALTEGRAVIR POTASSIUM [USP-RS]

Common Name

English

RALTEGRAVIR POTASSIUM COMPONENT OF DUTREBIS

Brand Name

English

RALTEGRAVIR POTASSIUM [MART.]

Common Name

English

RALTEGRAVIR POTASSIUM SALT

Common Name

English

RALTEGRAVIR POTASSIUM [EP MONOGRAPH]

Common Name

English

Raltegravir Potassium [WHO-DD]

Common Name

English

RALTEGRAVIR MONOPOTASSIUM SALT

Common Name

English

DUTREBIS COMPONENT RALTEGRAVIR POTASSIUM

Brand Name

English

RALTEGRAVIR MONOPOTASSIUM SALT [MI]

Common Name

English

ISENTRESS

Brand Name

English

Classification Tree Code System Code

EMA ASSESSMENT REPORTS

DUTREBIX (AUTHORIZED: HIV INFECTIONS)

Created by admin on Fri Dec 15 16:00:01 UTC 2023 , Edited by admin on Fri Dec 15 16:00:01 UTC 2023

EMA ASSESSMENT REPORTS

ISENTRESS (AUTHORIZED: HIV INFECTIONS)

Created by admin on Fri Dec 15 16:00:01 UTC 2023 , Edited by admin on Fri Dec 15 16:00:01 UTC 2023

Code System Code Type Description

USAN

SS-71

Created by admin on Fri Dec 15 16:00:01 UTC 2023 , Edited by admin on Fri Dec 15 16:00:01 UTC 2023

PRIMARY

SMS_ID

100000093434

Created by admin on Fri Dec 15 16:00:01 UTC 2023 , Edited by admin on Fri Dec 15 16:00:01 UTC 2023

PRIMARY

CAS

871038-72-1

Created by admin on Fri Dec 15 16:00:01 UTC 2023 , Edited by admin on Fri Dec 15 16:00:01 UTC 2023

PRIMARY

DRUG BANK

DBSALT000924

Created by admin on Fri Dec 15 16:00:01 UTC 2023 , Edited by admin on Fri Dec 15 16:00:01 UTC 2023

PRIMARY

PUBCHEM

23668479

Created by admin on Fri Dec 15 16:00:01 UTC 2023 , Edited by admin on Fri Dec 15 16:00:01 UTC 2023

PRIMARY

MERCK INDEX

m9486

Created by admin on Fri Dec 15 16:00:01 UTC 2023 , Edited by admin on Fri Dec 15 16:00:01 UTC 2023

PRIMARY

Merck Index

DAILYMED

43Y000U234

Created by admin on Fri Dec 15 16:00:01 UTC 2023 , Edited by admin on Fri Dec 15 16:00:01 UTC 2023

PRIMARY

ChEMBL

CHEMBL254316

Created by admin on Fri Dec 15 16:00:01 UTC 2023 , Edited by admin on Fri Dec 15 16:00:01 UTC 2023

PRIMARY

JAPANESE REVIEW

ISENTRESS

Created by admin on Fri Dec 15 16:00:01 UTC 2023 , Edited by admin on Fri Dec 15 16:00:01 UTC 2023

PRIMARY

APPROVED JUNE 2008

EVMPD

SUB25668

Created by admin on Fri Dec 15 16:00:01 UTC 2023 , Edited by admin on Fri Dec 15 16:00:01 UTC 2023

PRIMARY

EPA CompTox

DTXSID501007339

Created by admin on Fri Dec 15 16:00:01 UTC 2023 , Edited by admin on Fri Dec 15 16:00:01 UTC 2023

PRIMARY

FDA UNII

43Y000U234

Created by admin on Fri Dec 15 16:00:01 UTC 2023 , Edited by admin on Fri Dec 15 16:00:01 UTC 2023

PRIMARY

RXCUI

1235585

Created by admin on Fri Dec 15 16:00:01 UTC 2023 , Edited by admin on Fri Dec 15 16:00:01 UTC 2023

PRIMARY

RxNorm

RS_ITEM_NUM

1598278

Created by admin on Fri Dec 15 16:00:01 UTC 2023 , Edited by admin on Fri Dec 15 16:00:01 UTC 2023

PRIMARY

NCI_THESAURUS

C73823

Created by admin on Fri Dec 15 16:00:01 UTC 2023 , Edited by admin on Fri Dec 15 16:00:01 UTC 2023

PRIMARY

Related Record Type Details


					22VKV8053U

PARENT -> SALT/SOLVATE

Related Record Type Details


					9EJ47VP5SY

RALTEGRAVIR-1-ETHOXYACETHYDRAZONE, (E)-

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					92LUH56XKZ

DES(5-METHYL-1,3,4-OXADIAZOL)-(2-(2-ACETYLHYDRAZINO)-2-OXO-ACETYL)-RALTEGRAVIR

IMPURITY -> PARENT

Comments:

correction factor: multiply the peak area of impurity C by 1.6

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					92LUH56XKZ

DES(5-METHYL-1,3,4-OXADIAZOL)-(2-(2-ACETYLHYDRAZINO)-2-OXO-ACETYL)-RALTEGRAVIR

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					FB193O69MS

RALTEGRAVIR-1-ETHOXYACETHYDRAZONE, (Z)-

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					5U1A5S652K

RALTEGRAVIR AMINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					5U1A5S652K

RALTEGRAVIR AMINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					GW9D8B48NG

4-DEFLUORO RALTEGRAVIR

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					4R5S14FD9Y

DES(5-METHYL-1,3,4-OXADIAZOL)RALTEGRAVIR DIMER

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					9EJ47VP5SY

RALTEGRAVIR-1-ETHOXYACETHYDRAZONE, (E)-

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					UTE3M7YGV6

DES(5-METHYL-1,3,4-OXADIAZOLE-2-CARBOXAMIDE)-((E)-DIMETHYLAMINOMETHYLENEAMINO)RALTEGRAVIR

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					VCB1FAU7R0

DES(5-METHYL-1,3,4-OXADIAZOL)-OXALO-RALTEGRAVIR

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					GW9D8B48NG

4-DEFLUORO RALTEGRAVIR

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					UTE3M7YGV6

DES(5-METHYL-1,3,4-OXADIAZOLE-2-CARBOXAMIDE)-((E)-DIMETHYLAMINOMETHYLENEAMINO)RALTEGRAVIR

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					FB193O69MS

RALTEGRAVIR-1-ETHOXYACETHYDRAZONE, (Z)-

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

Related Record Type Details


					22VKV8053U

ACTIVE MOIETY