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Details

Stereochemistry ABSOLUTE
Molecular Formula C28H37ClO7
Molecular Weight 521.042
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BECLOMETHASONE DIPROPIONATE

SMILES

[H][C@@]12C[C@H](C)[C@](OC(=O)CC)(C(=O)COC(=O)CC)[C@@]1(C)C[C@H](O)[C@@]3(Cl)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

InChIKey=KUVIULQEHSCUHY-XYWKZLDCSA-N
InChI=1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1

HIDE SMILES / InChI
Molecular Formula C28H37ClO7
Molecular Weight 521.042
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 8 / 8
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:10:44 UTC 2023
Edited
by admin
on Fri Dec 15 15:10:44 UTC 2023
Record UNII
5B307S63B2
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BECLOMETHASONE DIPROPIONATE
MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF  
USAN  
Official Name English
TOPSTER
Brand Name English
PROPADERM FORTE
Common Name English
NSC-755901
Code English
SCH 8020W
Code English
QNASL
Common Name English
INALONE R
Common Name English
BECLOMETASONE DIPROPIONATE, ANHYDROUS [EP IMPURITY]
Common Name English
SGX-203
Code English
BECLOMETASONE DIPROPIONATE [JAN]
Common Name English
QVAR
Brand Name English
BECLOMETASONE DIPROPIONATE
WHO-DD   WHO-IP  
Common Name English
BECLOMETHASONE DIPROPIONATE [ORANGE BOOK]
Common Name English
BECLOMETHASONE DIPROPIONATE [USP IMPURITY]
Common Name English
BELCHLORHINOL
Common Name English
VANCENASE AQ
Common Name English
NASOBEC
Common Name English
BECLOMETHASONE DIPROPIONATE [MI]
Common Name English
BECLOMETHASONE 17,21-DIPROPRIONATE
Common Name English
VENTOLAIR
Brand Name English
Beclometasone dipropionate [WHO-DD]
Common Name English
BETAMETHASONE DIPROPIONATE IMPURITY E
Common Name English
BECLOMETASONE DIPROPIONATE ANHYDROUS
Common Name English
BECONASE
Brand Name English
BECLOMETHASONE DIPROPIONATE [USP MONOGRAPH]
Common Name English
ORBEC
Common Name English
ENTYDERMA
Common Name English
SGX-202
Code English
SGX-201
Code English
BECLOVENT
Brand Name English
ORBESHIELD
Brand Name English
SCH-18020W
Code English
SANASTHMAX
Brand Name English
BECLOMETHASONE DIPROPIONATE [USAN]
Common Name English
TRIMBOW COMPONENT BECLOMETHASONE DIPROPIONATE
Common Name English
SANASTHYMYL
Common Name English
SCH 18020W
Code English
CLENIL A
Common Name English
BECLOMETASONE DIPROPIONATE, ANHYDROUS
EP  
Common Name English
BECLOMETASONI DIPROPIONAS [WHO-IP LATIN]
Common Name English
9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate
Common Name English
VANCENASE
Brand Name English
BECLOMETASONE DIPROPIONATE [EP MONOGRAPH]
Common Name English
BECLOMETHASONE 17,21-DIPROPIONATE
Common Name English
BECLOMETHASONE DIPROPIONATE [USP-RS]
Common Name English
SERNIVO
Brand Name English
VANCERIL
Brand Name English
BECLOMETASONE DIPROPIONATE [WHO-IP]
Common Name English
KORBUTONE
Common Name English
BECLOMET
Brand Name English
BECLOMETHASONE DIPROPIONATE [VANDF]
Common Name English
PREGNA-1,4-DIENE-3,20-DIONE, 9-CHLORO-11-HYDROXY-16-METHYL-17,21-BIS(1-OXOPROPOXY)-, (11.BETA.,16.BETA.)-
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 356311
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
FDA ORPHAN DRUG 111198
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
NCI_THESAURUS C521
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
FDA ORPHAN DRUG 146501
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
FDA ORPHAN DRUG 144201
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
FDA ORPHAN DRUG 285609
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
Code System Code Type Description
SMS_ID
100000091556
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY
CHEBI
3002
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY
RS_ITEM_NUM
1048506
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY
FDA UNII
5B307S63B2
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY
DRUG CENTRAL
294
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
BECLOMETHASONE DIPROPIONATE
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY Description: A white to creamy white powder; odourless. Solubility: Practically insoluble in water; soluble in 60 parts of ethanol (~750 g/l) TS. Category: Antiasthmatic drug. Storage: Beclometasone dipropionate should be kept in a well-closed container, protected from light. Definition: Beclometasone dipropionate contains not less than 96.0% and not more than 104.0% of C28H37ClO7, calculated with reference to the dried substance.
DRUG BANK
DB00394
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY
EVMPD
SUB00681MIG
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY
RXCUI
1348
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY RxNorm
IUPHAR
5894
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY
DAILYMED
5B307S63B2
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY
NSC
755901
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY
ChEMBL
CHEMBL1200500
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY
ECHA (EC/EINECS)
226-886-0
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY
EPA CompTox
DTXSID3048730
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY
WIKIPEDIA
BECLOMETASONE DIPROPIONATE
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY
NCI_THESAURUS
C299
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY
EVMPD
SUB26515
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY
CAS
5534-09-8
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY
PUBCHEM
21700
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY
MERCK INDEX
m2287
Created by admin on Fri Dec 15 15:10:45 UTC 2023 , Edited by admin on Fri Dec 15 15:10:45 UTC 2023
PRIMARY Merck Index
Related Record Type Details
GLUCOCORTICOID RECEPTOR
TARGET -> AGONIST
Structure of BECLOMETHASONE DIPROPIONATE, CYCLO-3'-.BETA.-
DEGRADENT -> PARENT
Structure of BECLOMETHASONE DIPROPIONATE MONOHYDRATE
SOLVATE->ANHYDROUS
GLUCOCORTICOID RECEPTOR
TARGET -> AGONIST
Binds to the glucocorticoid receptor with about half the affinity of the potent glucocorticoid dexamethasone (Dexa), B was found to be 0·75 times less active than Dexa.
Structure of BECLOMETHASONE DIPROPIONATE, CYCLO-3'-.ALPHA.-
DEGRADENT -> PARENT
Structure of BECLOMETHASONE DIPROPIONATE MONOHYDRATE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of BECLOMETHASONE
METABOLITE INACTIVE -> PARENT
MINOR
PLASMA
Structure of BECLOMETASONE 21-PROPIONATE
METABOLITE LESS ACTIVE -> PARENT
Structure of BECLOMETHASONE 17-MONOPROPIONATE
METABOLITE ACTIVE -> PRODRUG
MAJOR
PLASMA
Related Record Type Details
Structure of 6.ALPHA.-BROMO-BECLOMETHASONE DIPROPIONATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of BETAMETHASONE 9,11-EPOXIDE 21-PROPIONATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 9-DESCHLORO-9-BROMO-BECLOMETHASONE DIPROPIONATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of BECLOMETHASONE 17-MONOPROPIONATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 16.BETA.-METHYL-3,20-DIOXOPREGNA-1,4,9(11)-TRIENE-17,21-DIYL DIPROPANOATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of BETAMETHASONE DIPROPIONATE
PARENT -> IMPURITY
http://apps.who.int/phint/pdf/b/Jb.6.1.43.pdf
Structure of BETAMETHASONE 9,11-EPOXIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 1,2-DIHYDRO-BECLOMETHASONE DIPROPIONATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 2-BROMO-BECLOMETHASONE DIPROPIONATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 6.ALPHA.-CHLORO-BECLOMETHASONE DIPROPIONATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of BECLOMETHASONE DIPROPIONATE 11-PROPIONATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 9,11.BETA.-DICHLORO-16.BETA.-METHYL-3,20-DIOXOPREGNA-1,4-DIENE-17,21-DIYL DIPROPANOATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 16.BETA.-METHYL-3,20-DIOXOPREGNA-1,4-DIENE-17,21-DIYL DIPROPANOATE
IMPURITY -> PARENT
Structure of BECLOMETHASONE 21-ACETATE 17-PROPIONATE
IMPURITY -> PARENT
Structure of BETAMETHASONE 9,11-EPOXIDE 17-PROPIONATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of BETAMETHASONE 9,11-EPOXIDE 17,21-DIPROPIONATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of BECLOMETHASONE 21-BUTYRATE 17-PROPIONATE
IMPURITY -> PARENT
Structure of 9-CHLORO-11.BETA.-HYDROXY-16.BETA.-METHYL-3,20-DIOXOPREGNA-4,6-DIENE-17,21-DIYL DIPROPANOATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of BECLOMETHASONE 17-MONOPROPIONATE
ACTIVE MOIETY
17-BMP is about 13 times as potent as Dexa.
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
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