COBIMETINIB FUMARATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	2C21H21F3IN3O2.C4H4O4
Molecular Weight	1178.6922
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C\C(O)=O.[H][C@]1(CCCCN1)C2(O)CN(C2)C(=O)C3=C(NC4=CC=C(I)C=C4F)C(F)=C(F)C=C3.[H][C@]5(CCCCN5)C6(O)CN(C6)C(=O)C7=C(NC8=CC=C(I)C=C8F)C(F)=C(F)C=C7

InChI

InChIKey=RESIMIUSNACMNW-BXRWSSRYSA-N

InChI=1S/2C21H21F3IN3O2.C4H4O4/c2*22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17;5-3(6)1-2-4(7)8/h2*4-7,9,17,26-27,30H,1-3,8,10-11H2;1-2H,(H,5,6)(H,7,8)/b;;2-1+/t2*17-;/m00./s1

HIDE SMILES / InChI

Molecular Formula	C21H21F3IN3O2
Molecular Weight	531.31
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	C4H4O4
Molecular Weight	116.0722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 20:19:33 UTC 2023` Edited by `admin` on `Fri Dec 15 20:19:33 UTC 2023`
Record UNII	6EXI96H8SV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

COBIMETINIB FUMARATE

Official Name

English

COTELLIC

Brand Name

English

XL-518 HEMIFUMARATE

Common Name

English

COBIMETINIB HEMIFUMARATE

Common Name

English

Bis({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}{3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl}methanone) (2E)-but-2-enedioate

Common Name

English

COBIMETINIB FUMARATE [MI]

Common Name

English

COBIMETINIB FUMARATE [JAN]

Common Name

English

Cobimetinib hemifumarate [WHO-DD]

Common Name

English

COBIMETINIB FUMARATE [ORANGE BOOK]

Common Name

English

COBIMETINIB FUMARATE [USAN]

Common Name

English

METHANONE, (3,4-DIFLUORO-2-((2-FLUORO-4-IODOPHENYL)AMINO)PHENYL)(3-HYDROXY-3-(2S)-2-PIPERIDINYL-1-AZETIDINYL)-, (2E)-2-BUTENEDIOATE (2:1)

Common Name

English

GDC-0973 HEMIFUMARATE

Common Name

English

Classification Tree Code System Code

EMA ASSESSMENT REPORTS

COTELLIC (AUTHORIZED: MELANOMA)