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Details

Stereochemistry ACHIRAL
Molecular Formula C6H10N6O
Molecular Weight 182.1832
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of DACARBAZINE

SMILES

CN(C)\N=N\C1=C(N=CN1)C(N)=O

InChI

InChIKey=FDKXTQMXEQVLRF-ZHACJKMWSA-N
InChI=1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+

HIDE SMILES / InChI
Molecular Formula C6H10N6O
Molecular Weight 182.1832
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:09:29 UTC 2023
Edited
by admin
on Fri Dec 15 16:09:29 UTC 2023
Record UNII
7GR28W0FJI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DACARBAZINE
EP   HSDB   INN   JAN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
USAN   INN  
Official Name English
DACARBAZINE [WHO-IP]
Common Name English
DIC
Common Name English
DTIC
Common Name English
DACARBASINE
Common Name English
dacarbazine [INN]
Common Name English
1H-IMIDAZOLE-4-CARBOXAMIDE, 5-(3,3-DIMETHYL-1-TRIAZENYL)-
Systematic Name English
DACARBAZINE [ORANGE BOOK]
Common Name English
Dacarbazine [WHO-DD]
Common Name English
DACARBAZINE [USP MONOGRAPH]
Common Name English
DACARBAZINE [HSDB]
Common Name English
DTIC-DOME
Brand Name English
DACARBAZINE [USP-RS]
Common Name English
DACARBAZINE [MI]
Common Name English
DACARBAZINE [VANDF]
Common Name English
DECARBAZINE
Common Name English
NSC-45388
Code English
NCI C04717
Code English
DACARBAZINE [IARC]
Common Name English
DACARBAZINE [EP MONOGRAPH]
Common Name English
IMIDAZOLE CARBOXAMIDE
Systematic Name English
DACARBAZINE [USAN]
Common Name English
DACARBAZINE [MART.]
Common Name English
DACARBAZINUM [WHO-IP LATIN]
Common Name English
DACARBAZINE [JAN]
Common Name English
5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide
Systematic Name English
BIOCARBAZINE R
Common Name English
DICARBAZINE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C902
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
LIVERTOX NBK548913
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
WHO-ATC L01AX04
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
NDF-RT N0000175558
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
WHO-VATC QL01AX04
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
WHO-ESSENTIAL MEDICINES LIST 8.2
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
Code System Code Type Description
RS_ITEM_NUM
1162308
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
DAILYMED
7GR28W0FJI
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
SMS_ID
100000088395
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
INN
3232
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
FDA UNII
7GR28W0FJI
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
DRUG BANK
DB00851
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
NSC
45388
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
LACTMED
Dacarbazine
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
WIKIPEDIA
DACARBAZINE
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
HSDB
3219
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
CAS
4342-03-4
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
NCI_THESAURUS
C411
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
EPA CompTox
DTXSID0020369
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
PUBCHEM
135398738
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
ECHA (EC/EINECS)
224-396-1
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
ChEMBL
CHEMBL476
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
DACARBAZINE
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY Description: A colourless or pale yellow, crystalline powder.Solubility: Slightly soluble in water and ethanol (~750 g/l) TS.Category: Cytotoxic drug.Storage: Dacarbazine should be kept in a tightly closed container, protected from light, and stored at a temperature notexceeding 8 ?C.Additional information: CAUTION: Dacarbazine must be handled with care, avoiding contact with the skin and inhalation ofairborne particles.
MERCK INDEX
m4065
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY Merck Index
CHEBI
4305
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
EVMPD
SUB06882MIG
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
MESH
D003606
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
DRUG CENTRAL
773
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY
RXCUI
3098
Created by admin on Fri Dec 15 16:09:29 UTC 2023 , Edited by admin on Fri Dec 15 16:09:29 UTC 2023
PRIMARY RxNorm
Related Record Type Details
CYTOCHROME P450 2E1
METABOLIC ENZYME -> SUBSTRATE
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CYTOCHROME P450 1A1
METABOLIC ENZYME -> SUBSTRATE
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CYTOCHROME P450 1A2
METABOLIC ENZYME -> SUBSTRATE
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PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
Structure of DACARBAZINE CITRATE
SALT/SOLVATE -> PARENT
Structure of DACARBAZINE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
CYTOCHROME P450 1A2
METABOLIC ENZYME -> SUBSTRATE
Km
CYTOCHROME P450 1A1
METABOLIC ENZYME -> SUBSTRATE
Km
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Plasma exposure to AIC was equivalent to that of DTIC, whereas urinary recovery of DTIC and AIC was low and highly variable.
MAJOR
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METABOLITE -> PARENT
Structure of HMMTIC
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Structure of N-NITROSOMETHYLAMINE
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Structure of MTIC
METABOLITE ACTIVE -> PRODRUG
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Structure of HMMTIC
METABOLITE -> PARENT
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IMPURITY -> PARENT
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Structure of 5-DIAZENYL-1H-IMIDAZOLE-4-CARBOXAMIDE
IMPURITY -> PARENT
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC
NIH
NCATS
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