Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 14:51:00 UTC 2023
by
admin
on
Sat Dec 16 14:51:00 UTC 2023
|
| Protein Type | GROWTH FACTOR |
| Protein Sub Type | |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
J4PM6GL09E
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
J4PM6GL09E
Created by
admin on Sat Dec 16 14:51:00 UTC 2023 , Edited by admin on Sat Dec 16 14:51:00 UTC 2023
|
PRIMARY | |||
|
O14944
Created by
admin on Sat Dec 16 14:51:00 UTC 2023 , Edited by admin on Sat Dec 16 14:51:00 UTC 2023
|
PRIMARY |
| From | To |
|---|---|
| 1_6 | 1_19 |
| 1_14 | 1_30 |
| 1_32 | 1_41 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
INHIBITOR -> TARGET |
Binds to key residues in the C‐terminal regions of TGF‐α and epiregulin, preventing their binding to the EGFR. Engagement of the 2 targets by LY results in internalization of the transmembrane precursors and neutralization of the activity of the mature ligands in vitro.
|
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
|