PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM

Approval Year

Substance Class	Protein
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	JQ83GG8LT2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM

Common Name

English

PI3-KINASE SUBUNIT ALPHA

Common Name

English

PTDINS-3-KINASE SUBUNIT ALPHA

Common Name

English

PHOSPHOINOSITIDE-3-KINASE CATALYTIC ALPHA POLYPEPTIDE

Common Name

English

PI3K-ALPHA

Common Name

English

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Code System

Code

Type

Description

DRUG BANK

DB14954

PRIMARY

FDA UNII

JQ83GG8LT2

PRIMARY

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Subunit 0

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Related Record

Type

Details


					43J9Q56T3W

SERABELISIB

INHIBITOR -> TARGET

Comments:

Selective, oral bioavailable PI3Kα isoform inhibitor s more than 100-fold selective than other class I PI3K isoforms and mTOR as well as a high degree of selectivity against a large panel of protein kinases with potential antitumor activity.

Qualification:

IC50

Amount:

21 NANOMOLAR (average)


					L4C1UY2NYH

INAVOLISIB

INHIBITOR -> TARGET

Comments:

selective for alpha isoform, and leads to degradation of mutant p110 alpha PI3K subunit.

Qualification:

Ki

Amount:

0.034 NANOMOLAR (average)


					0ZM2Z182GD

BUPARLISIB

INHIBITOR -> TARGET


					K0068GK39A

ZSTK-474

INHIBITOR -> TARGET

Amount:


					2H36UAA53E

VDC-597

INHIBITOR -> TARGET

Amount:

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL

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