N-NITROSODIMETHYLAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H6N2O
Molecular Weight	74.0818
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CN(C)N=O

InChI

InChIKey=UMFJAHHVKNCGLG-UHFFFAOYSA-N

InChI=1S/C2H6N2O/c1-4(2)3-5/h1-2H3

HIDE SMILES / InChI

Molecular Formula	C2H6N2O
Molecular Weight	74.0818
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical
Record UNII	M43H21IO8R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

N-NITROSODIMETHYLAMINE

Systematic Name

English

DIMETHYLNITROSAMINE

Common Name

English

N-NITROSODIMETHYLAMINE [HSDB]

Common Name

English

N-NITROSODIMETHYLAMINE [USP-RS]

Common Name

English

DMN

Common Name

English

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Classification Tree

Code System

Code

IARC

IARC

<i>N</i>-Nitrosodimethylamine

Nitroso Carcinogen

NCI_THESAURUS

C45398

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Code System

Code

Type

Description

MERCK INDEX

m7994

PRIMARY

Merck Index

CHEBI

59990

PRIMARY

WIKIPEDIA

N-NITROSODIMETHYLAMINE

PRIMARY

RS_ITEM_NUM

1466674

PRIMARY

HSDB

1667

PRIMARY

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Related Record

Type

Details


					03BYF220B6

CYTOCHROME P450 2E1

METABOLIC ENZYME -> SUBSTRATE

Amount:

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Type

Details


					1HG84L3525

Formaldehyde

METABOLITE TOXIC -> PARENT

Comments:

Formed from breakdown of hydroxymethylmethylnitrosamine can alkylate DNA

Amount:


					638YVT1BYD

N-NITROSOMETHYLAMINE

METABOLITE TOXIC -> PARENT

Comments:

Activated to methylate DNA

Amount:


					F993PCT4MK

Hydroxymethylmethylnitrosamine

METABOLITE TOXIC -> PARENT

Comments:

Activates N-nitrosoamine to alkylate DNA.

Interaction Type:

MAJOR

Amount:


					4MD529UV3B

Methanediazonium

METABOLITE TOXIC -> PARENT

Comments:

Akylating agent

Amount:

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Type

Details


					80M03YXJ7I

VALSARTAN

PARENT -> IMPURITY

Comments:

NDMA is an organic chemical that is in a family of potent carcinogens.

Amount:

Other 0.0001 mg/day (average)
Value based on a drug's maximum daily dose of 320 mg/day as reflected on the drug label.


					2KH13Z0S0Y

EPROSARTAN

PARENT->IMPURITY GENOTOXIC

Comments:

NDMA is an organic chemical that is in a family of potent carcinogens.

Amount:

Other 0.12 PPM (average)
Limit value based on a drug's maximum daily dose of 800 mg/day as reflected on the drug label.


					J0E2756Z7N

IRBESARTAN

PARENT->IMPURITY GENOTOXIC

Comments:

NDMA is an organic chemical that is in a family of potent carcinogens.

Amount:

Other 0.32 PPM (average)
Value based on a drug's maximum daily dose of 300 mg/day as reflected on the drug label.


					F9NUX55P23

AZILSARTAN

PARENT->IMPURITY GENOTOXIC

Comments:

NDMA is an organic chemical that is in a family of potent carcinogens.

Amount:

Other 1.2 PPM (average)
Value based on a drug's maximum daily dose of 80 mg/day as reflected on the drug label.


					8W1IQP3U10

OLMESARTAN

PARENT->IMPURITY GENOTOXIC

Comments:

NDMA is an organic chemical that is in a family of potent carcinogens.

Amount:

Other 2.4 PPM (average)
Limit value based on a drug's maximum dose of 40 mg/day as reflected on the drug label.

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