BETA-3 ADRENERGIC RECEPTOR

Approval Year

Substance Class	Protein
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	PG244BS39U
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BETA-3 ADRENERGIC RECEPTOR

Common Name

English

B3AR

Common Name

English

ADRB3R

Common Name

English

beta3

Common Name

English

β3-Adrenergic Receptor

Common Name

English

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Code System

Code

Type

Description

FDA UNII

PG244BS39U

PRIMARY

PHAROS

P13945

PRIMARY

WIKIPEDIA

BETA-3_ADRENERGIC_RECEPTOR

PRIMARY

UNIPROT

P13945

PRIMARY

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Subunit 0

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From	To
1_110	1_196
1_189	1_195

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Glycosylation Type

HUMAN

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Glycosylation Link Type	Site
N	1_8
N	1_26

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Related Record

Type

Details


					4IJ6WR3BW8

Vemtoberant

INHIBITOR -> TARGET

Amount:


					588N0603CT

LEVISOPRENALINE

AGONIST -> TARGET

Qualification:

EC50

Amount:

18.6 NANOMOLAR [15.8 to 21.9] (average)


					D6P84R4E5Y

Iodocyanopindolol I-125

RADIOLIGAND->TARGET

Comments:

Chinese hamster ovary (CHO) cells stably expressing the three β-adrenergic receptor subtypes at comparable levels.

Qualification:

Kd

Amount:

0.285 NANOMOLAR [0.126 to 0.399] (average)


					YKH834O4BH

EPINEPHRINE

TARGET->WEAK AGONIST

Comments:

Assay in chinese hamster ovary (CHO) cells stably expressing the three β-adrenergic receptor subtypes at comparable leve50 to 80 pM 125I-CYP were used as radioligand. Experiments were done in the presence of 100 µM GTP.

Qualification:

Ki

Amount:

126000 NANOMOLAR [116000 to 136000] (average)


					WP4LUA5RAK

Iodocyanopindolol

INHIBITOR -> TARGET

Comments:

Chinese hamster ovary (CHO) cells stably expressing the three β-adrenergic receptor subtypes at comparable levels.

Qualification:

Kd

Amount:

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL
Molecular Formula	CHEMICAL	ESTIMATED C1979H3108N540O519S23

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