FOSTAMATINIB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H26FN6O9P
Molecular Weight	580.4595
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of FOSTAMATINIB

Structure Search

SMILES

COC1=CC(NC2=NC=C(F)C(NC3=NC4=C(OC(C)(C)C(=O)N4COP(O)(O)=O)C=C3)=N2)=CC(OC)=C1OC

InChI

InChIKey=GKDRMWXFWHEQQT-UHFFFAOYSA-N

InChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29)

HIDE SMILES / InChI

Molecular Formula	C23H26FN6O9P
Molecular Weight	580.4595
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:37:04 UTC 2023` Edited by `admin` on `Fri Dec 15 16:37:04 UTC 2023`
Record UNII	SQ8A3S5101
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FOSTAMATINIB

Official Name

English

2H-PYRIDO(3,2-B)-1,4-OXAZIN-3(4H)-ONE, 6-((5-FLUORO-2-((3,4,5-TRIMETHOXYPHENYL)AMINO)-4-PYRIMIDINYL)AMINO)-2,2-DIMETHYL-4-((PHOSPHONOOXY)METHYL)-

Systematic Name

English

R935788 FREE ACID

Code

English

Fostamatinib [WHO-DD]

Common Name

English

(6-((5-FLUORO-2-((3,4,5-TRIMETHOXYPHENYL)AMINO)PYRIMIDIN-4-YL)AMINO)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-PYRIDO(3,2-B)(1,4)OXAZIN-4-YL)METHYL DIHYDROGEN PHOSPHATE

Systematic Name

English

R-788 FREE ACID

Code

English

R788 FREE ACID

Code

English

fostamatinib [INN]

Common Name

English

R-935788 FREE ACID

Code

English

FOSTAMATINIB [MI]

Common Name

English

FOSTAMATINIB [USAN]

Common Name

English

Classification Tree Code System Code

WHO-ATC

B02BX09

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

FDA ORPHAN DRUG

544516

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

NCI_THESAURUS

C1967

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

Code System Code Type Description

ChEMBL

CHEMBL2103830

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

PRIMARY

WIKIPEDIA

FOSTAMATINIB

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

PRIMARY

INN

9022

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

PRIMARY

USAN

WW-03

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

PRIMARY

DAILYMED

SQ8A3S5101

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

PRIMARY

NCI_THESAURUS

C95222

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

PRIMARY

DRUG CENTRAL

5280

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

PRIMARY

MESH

C523665

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

PRIMARY

PUBCHEM

11671467

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

PRIMARY

EPA CompTox

DTXSID401009170

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

PRIMARY

FDA UNII

SQ8A3S5101

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

PRIMARY

DRUG BANK

DB12010

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

PRIMARY

RXCUI

2044896

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

PRIMARY

SMS_ID

100000128457

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

PRIMARY

CAS

901119-35-5

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

PRIMARY

EVMPD

SUB35500

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

PRIMARY

MERCK INDEX

m5557

Created by admin on Fri Dec 15 16:37:05 UTC 2023 , Edited by admin on Fri Dec 15 16:37:05 UTC 2023

PRIMARY

Merck Index

Related Record Type Details


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE


					86EEZ49YVB

FOSTAMATINIB DISODIUM

SALT/SOLVATE -> PARENT


					JS20X60RRY

TYROSINE-PROTEIN KINASE SYK

TARGET -> INHIBITOR

Amount:


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

METABOLIC ENZYME -> INHIBITOR


					X9417132K8

FOSTAMATINIB DISODIUM ANHYDROUS

SALT/SOLVATE -> PARENT


					3318TFY23Q

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A9

METABOLIC ENZYME -> SUBSTRATE


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:

Related Record Type Details


					ZP3U7X9EAM

N-GLUCURONIDE R-406

METABOLITE -> PARENT

Qualification:

PLASMA; URINE


					RC3A285J2G

TAMATINIB

METABOLITE ACTIVE -> PRODRUG

Interaction Type:

MAJOR

Amount:


					B5MW0MGI3L

P-DE(METHOXY)-M,M-DEMETHYL-TAMATINIB

METABOLITE -> PARENT

Qualification:

FECAL


					JR1IDX058G

R-529

METABOLITE -> PARENT


					T441NJ0BM5

2H-PYRIDO(3,2-B)-1,4-OXAZIN-3(4H)-ONE, 6-((2-((3,5-DIMETHOXY-4-(SULFOOXY)PHENYL)AMINO)-5-FLUORO-4-PYRIMIDINYL)AMINO)-2,2-DIMETHYL-

METABOLITE -> PARENT

Qualification:

PLASMA


					37YV3YP3TP

O-GLUCURONIDE R-529

METABOLITE -> PARENT

Qualification:

PLASMA

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC

Tmax	PHARMACOKINETIC				DOSE