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Development Status
Investigational
14
US Approved Rx
7
Possibly Marketed Outside US
3
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Primary Target
Tyrosine-protein kinase receptor FLT3
3
DNA topoisomerase I
2
DNA topoisomerase II alpha
2
Multidrug resistance-associated protein 1
2
Platelet-derived growth factor receptor alpha
2
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Highest Phase
Approved
7
Phase III
7
Phase II
3
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Approval Year
Unknown
16
1979
2
2018
2
2006
1
2014
1
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Condition
Acute myeloid leukemia
10
Myelodysplastic syndromes
6
Acute lymphoblastic leukemia
3
Acute myeloblastic leukemia
2
Neuroblastoma
2
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Treatment Modality
Primary
17
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CNS Activity
CNS Penetrant
6
CNS Non-penetrant
1
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Originator
Agios Pharmaceuticals
2
Hahn, A.|Dumaitre, P.
2
Ambit Biosciences
1
Astellas Pharma
1
Boehringer Ingelheim
1
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Substance Class
Chemical
23
Protein
1
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Code System
CAS
24
EU-Orphan Drug
24
FDA UNII
24
NCI_THESAURUS
23
SMS_ID
23
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Protein Type
MONOCLONAL ANTIBODY
1
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ATC Level 1
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
2
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ATC Level 2
ANTINEOPLASTIC AGENTS
2
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ATC Level 3
OTHER ANTINEOPLASTIC AGENTS
2
CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
1
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ATC Level 4
Anthracyclines and related substances
1
Combinations of antineoplastic agents
1
Other antineoplastic agents
1
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Substance Form
Principal Form
14
Salts, Hydrates, Esters, etc.
10
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Search results for
"EU ORPHAN DRUG|Positive|Treatment of acute myeloid leukaemia"
in
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TIPIFARNIB
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MAT637500A
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Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
CYTOSINE
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8J337D1HZY
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Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
VOSAROXIN
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K6A90IIZ19
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Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
ULOCUPLUMAB
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7KNP87L4X4
Subunit
1
(451) Similarity Search
Subunit
2
(451) Similarity Search
Subunit
3
(214) Similarity Search
Subunit
4
(214) Similarity Search
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Subunit
1
(451) Similarity Search
Subunit
2
(451) Similarity Search
Subunit
3
(214) Similarity Search
Subunit
4
(214) Similarity Search
Status:
Other
Class:
PROTEIN
QUIZARTINIB DIHYDROCHLORIDE
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WK7Q6ZIZ10
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Class (Stereo):
CHEMICAL (ACHIRAL)
ENASIDENIB MESYLATE
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UF6PC17XAV
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Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
GUADECITABINE SODIUM
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0RB89YH367
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Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
DAUNORUBICIN CITRATE
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5L84T2Z6NP
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Class (Stereo):
CHEMICAL (ABSOLUTE)
IADADEMSTAT DIHYDROCHLORIDE
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G02YXY861Q
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Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
UPROLESELAN SODIUM
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17ZJN0Q4CJ
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Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
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