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Development Status
US Approved Rx
27
US Previously Marketed
4
US Approved OTC
2
Possibly Marketed Outside US
1
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Primary Target
Cyclooxygenase-2
14
Cyclooxygenase-1
11
Mu opioid receptor
11
Kappa opioid receptor
6
Cyclooxygenase
5
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Highest Phase
Approved
32
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Approval Year
1827
1
1921
2
1943
2
1950
1
1956
1
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Condition
Osteoarthritis
17
Rheumatoid arthritis
15
Pain
13
Ankylosing spondylitis
4
Acute pain
3
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Treatment Modality
Primary
24
Palliative
12
Preventing
1
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CNS Activity
CNS Active
15
CNS Penetrant
9
CNS Non-penetrant
2
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Originator
Merck
2
Syntex
2
Adams, S. at Boots Pure Drug
1
Bayer
1
Beecham Group
1
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Substance Class
Chemical
33
Structurally Diverse
1
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Code System
CAS
34
DRUG BANK
34
EVMPD
34
FDA UNII
34
LIVERTOX
34
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ATC Level 1
MUSCULO-SKELETAL SYSTEM
17
NERVOUS SYSTEM
16
RESPIRATORY SYSTEM
6
SENSORY ORGANS
5
ALIMENTARY TRACT AND METABOLISM
3
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ATC Level 2
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
17
ANALGESICS
15
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
8
OPHTHALMOLOGICALS
5
COUGH AND COLD PREPARATIONS
4
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ATC Level 3
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
16
OPIOIDS
12
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
8
ANTIINFLAMMATORY AGENTS
5
OTHER ANALGESICS AND ANTIPYRETICS
4
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ATC Level 4
Antiinflammatory preparations, non-steroids for topical use
8
Acetic acid derivatives and related substances
6
Opioids in combination with non-opioid analgesics
6
Antiinflammatory agents, non-steroids
5
Natural opium alkaloids
5
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Substance Form
Principal Form
30
Salts, Hydrates, Esters, etc.
4
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Search results for
"LiverTox|Analgesic"
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PIROXICAM
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13T4O6VMAM
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Other
Class (Stereo):
CHEMICAL (ACHIRAL)
DIFLUNISAL
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7C546U4DEN
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CHEMICAL (ACHIRAL)
SULINDAC
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184SNS8VUH
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CHEMICAL (RACEMIC)
BUTORPHANOL
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QV897JC36D
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CHEMICAL (ABSOLUTE)
FENOPROFEN
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RA33EAC7KY
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CHEMICAL (RACEMIC)
TOLMETIN
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D8K2JPN18B
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CHEMICAL (ACHIRAL)
NAPROXEN
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57Y76R9ATQ
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CHEMICAL (ABSOLUTE)
IBUPROFEN
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WK2XYI10QM
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CHEMICAL (RACEMIC)
PENTAZOCINE
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RP4A60D26L
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Class (Stereo):
CHEMICAL (RACEMIC)
MEFENAMIC ACID
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367589PJ2C
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Class (Stereo):
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