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Development Status
US Previously Marketed
14
Possibly Marketed Outside US
10
US Approved Rx
10
Investigational
8
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Primary Target
Acetylcholinesterase
31
Butyrylcholinesterase
5
Cholinesterase
2
Dopamine D2 receptor
2
Muscarinic acetylcholine receptor M1
2
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Highest Phase
Approved
30
Phase II
2
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Approval Year
Unknown
18
1921
3
1931
3
1955
3
1956
3
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Condition
Alzheimer’s disease
10
Myasthenia gravis
9
Glaucoma
4
Accommodative esotropia
2
Chronic gastritis
2
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Treatment Modality
Primary
22
Palliative
11
Preventing
3
Curative
2
Diagnostic
1
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CNS Activity
CNS Active
14
CNS Non-penetrant
9
CNS Penetrant
5
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Originator
Aeschlimann, J.A.|Reinert, M.
3
Eisai
3
Sanofi
3
Cavallito, C.J. et al.
2
Chemie Linz
2
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Substance Class
Chemical
42
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Code System
CAS
42
FDA UNII
42
NCI_THESAURUS
42
PUBCHEM
42
EPA CompTox
38
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ATC Level 1
NERVOUS SYSTEM
6
SENSORY ORGANS
5
ALIMENTARY TRACT AND METABOLISM
1
ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
1
MUSCULO-SKELETAL SYSTEM
1
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ATC Level 2
OPHTHALMOLOGICALS
5
OTHER NERVOUS SYSTEM DRUGS
3
PSYCHOANALEPTICS
3
ALL OTHER THERAPEUTIC PRODUCTS
1
ANTHELMINTICS
1
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ATC Level 3
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
5
ANTI-DEMENTIA DRUGS
3
PARASYMPATHOMIMETICS
3
ALL OTHER THERAPEUTIC PRODUCTS
1
ANTITREMATODALS
1
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ATC Level 4
Anticholinesterases
6
Parasympathomimetics
5
Antidotes
1
Organophosphorous compounds
1
Other quaternary ammonium compounds
1
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Substance Form
Principal Form
23
Salts, Hydrates, Esters, etc.
19
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Search results for
"Pharmacologic Substance[C1909]|Enzyme Inhibitor[C471]|Acetylcholinesterase Inhibitor"
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VELNACRINE
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Y2P6NV151K
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Status:
Other
Class (Stereo):
CHEMICAL (RACEMIC)
ACOTIAMIDE
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D42OWK5383
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CHEMICAL (ACHIRAL)
ITOPRIDE
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81BMQ80QRL
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Class (Stereo):
CHEMICAL (ACHIRAL)
RIVASTIGMINE TARTRATE
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9IY2357JPE
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CHEMICAL (ABSOLUTE)
DONEPEZIL OXALATE
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SLF7M28SI5
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Class (Stereo):
CHEMICAL (RACEMIC)
DONEPEZIL HYDROCHLORIDE
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3O2T2PJ89D
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Class (Stereo):
CHEMICAL (RACEMIC)
NEOSTIGMINE METHYLSULFATE
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98IMH7M386
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Class (Stereo):
CHEMICAL (ACHIRAL)
NEOSTIGMINE BROMIDE
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005SYP50G5
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CHEMICAL (ACHIRAL)
SURONACRINE MALEATE
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NO3H145KZO
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Class (Stereo):
CHEMICAL (RACEMIC)
LADOSTIGIL TARTRATE
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2J1346C51H
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Class (Stereo):
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