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Development Status
Investigational
9
US Approved Rx
6
Possibly Marketed Outside US
5
Designated
1
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Primary Target
Vascular endothelial growth factor receptor 2
3
Platelet-derived growth factor receptor alpha
2
Platelet-derived growth factor receptor beta
2
Dihydropyrimidine dehydrogenase [NADP(+)]
1
Fibroblast growth factor receptor 1
1
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Highest Phase
Approved
8
Phase III
3
Phase I
1
Phase II
1
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Approval Year
Unknown
15
1962
1
1974
1
1990
1
1992
1
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Condition
Gastric cancer
4
Breast cancer
3
Glioblastoma
2
Multiple myeloma
2
Adenocarcinoma of the colon
1
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Treatment Modality
Primary
13
Secondary
1
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CNS Activity
CNS Penetrant
5
CNS Active
4
CNS Non-penetrant
1
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Originator
AB Science
1
Array BioPharma
1
AstraZeneca
1
Bacchi, C.
1
Biltz, H.|Giesler, E.
1
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Substance Class
Chemical
18
Protein
3
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Code System
CAS
21
FDA ORPHAN DRUG
21
FDA UNII
21
NCI_THESAURUS
21
SMS_ID
19
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Protein Type
MONOCLONAL ANTIBODY
3
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ATC Level 1
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
6
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ATC Level 2
ANTINEOPLASTIC AGENTS
6
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ATC Level 3
OTHER ANTINEOPLASTIC AGENTS
3
ANTIMETABOLITES
1
CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
1
PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
1
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ATC Level 4
Monoclonal antibodies
2
Anthracyclines and related substances
1
Protein kinase inhibitors
1
Pyrimidine analogues
1
Taxanes
1
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Substance Form
Principal Form
15
Salts, Hydrates, Esters, etc.
6
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Search results for
"ORPHAN DRUG|Designated|Treatment of gastric cancer"
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IBRUTINIB
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1X70OSD4VX
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Class (Stereo):
CHEMICAL (ABSOLUTE)
PACLITAXEL
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P88XT4IS4D
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CHEMICAL (ABSOLUTE)
DOXORUBICIN
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80168379AG
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ALRIZOMADLIN
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15QAU0SI9J
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CHEMICAL (ABSOLUTE)
VACTOSERTIB
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6T4O391P5Y
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CHEMICAL (ACHIRAL)
Fexagratinib
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2167OG1EKJ
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CHEMICAL (ACHIRAL)
CRENOLANIB
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LQF7I567TQ
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CHEMICAL (ACHIRAL)
VARLITINIB
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846Y8197W1
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CHEMICAL (ABSOLUTE)
TESETAXEL
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UG97LO5M8Y
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CHEMICAL (ABSOLUTE)
MONOMETHYL AURISTATIN E
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V7I58RC5EJ
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