U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C19H30N5O10P.C4H4O4
Molecular Weight 635.5149
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of TENOFOVIR DISOPROXIL FUMARATE

SMILES

OC(=O)\C=C\C(O)=O.CC(C)OC(=O)OCOP(=O)(CO[C@H](C)CN1C=NC2=C1N=CN=C2N)OCOC(=O)OC(C)C

InChI

InChIKey=VCMJCVGFSROFHV-WZGZYPNHSA-N
InChI=1S/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+/t14-;/m1./s1

HIDE SMILES / InChI

Approval Year

Unknown
86413
Name Type Language
TENOFOVIR DISOPROXIL FUMARATE
EMA EPAR   HSDB   JAN   MART.   MI   ORANGE BOOK   USAN   USP-RS   VANDF   WHO-DD   WHO-IP  
USAN  
Official Name English
TENOFOVIR DISOPROXIL FUMARATE [JAN]
Common Name English
TENOFOVIR DISOPROXIL FUMARATE COMPONENT OF ODEFSEY
Common Name English
TENOFOVIR DISOPROXIL FUMARATE [HSDB]
Common Name English
TENOFOVIR DISOPROXIL FUMARATE COMPONENT OF TEMIXYS
Common Name English
GS-4331-05
Code English
TENOFOVIR DISOPROXIL FUMARATE [USAN]
Common Name English
9-((R)-2-((BIS(((ISOPROPOXYCARBONYL)OXY)-METHOXY)PHOSPHINYL)METHOXY)PROPYL)ADENINE FUMARATE (1:1)
Common Name English
TENOFOVIR DF
Common Name English
TENOFOVIR (AS DISOPROXIL FUMARATE)
Common Name English
TENOFOVIR DISOPROXIL FUMARATE [VANDF]
Common Name English
TENOFOVIR DISOPROXIL FUMARATE COMPONENT OF STRIBILD
Brand Name English
TENOFOVIR DISOPROXIL FUMARATE COMPONENT OF TRUVADA
Brand Name English
GSK548470
Code English
TENOFOVIR DISOPROXIL FUMARATE [WHO-IP]
Common Name English
TENOFOVIR DISOPROXIL FUMARATE COMPONENT OF EVIPLERA
Brand Name English
Tenofovir disoproxil fumarate [WHO-DD]
Common Name English
TENOFOVIR DISOPROXIL FUMARATE [MI]
Common Name English
TENOFOVIRI DISOPROXILI FUMARAS [WHO-IP LATIN]
Common Name English
EVIPLERA COMPONENT TENOFOVIR DISOPROXIL FUMARATE
Brand Name English
TENOFOVIR DISOPROXIL FUMARATE [EMA EPAR]
Common Name English
ATRIPLA COMPONENT TENOFOVIR DISOPROXIL FUMARATE
Common Name English
TEMIXYS COMPONENT TENOFOVIR DISOPROXIL FUMARATE
Common Name English
VIREAD
Brand Name English
TENOFOVIR DISOPROXIL FUMARATE [ORANGE BOOK]
Common Name English
GSK-548470
Code English
ODEFSEY COMPONENT TENOFOVIR DISOPROXIL FUMARATE
Common Name English
TENOFOVIR DISOPROXIL FUMARATE [MART.]
Common Name English
STRIBILD COMPONENT TENOFOVIR DISOPROXIL FUMARATE
Brand Name English
PMPA-PRODRUG
Code English
TENOFOVIR DISOPROXIL FUMARATE [USP-RS]
Common Name English
Bis(hydroxymethyl) [[(R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonate, bis(isopropyl carbonate) (ester), fumarate (1:1)
Common Name English
TENOFOVIR DISOPROXIL FUMARATE COMPONENT OF ATRIPLA
Common Name English
DELSTRIGO COMPONENT TENOFOVIR DISOPROXIL FUMARATE
Brand Name English
GS-4331-05-
Code English
PMPA PRODRUG
Code English
TENOFOVIR DISOPROXIL FUMARATE COMPONENT DELSTRIGO
Brand Name English
TRUVADA COMPONENT TENOFOVIR DISOPROXIL FUMARATE
Brand Name English
(R)-5-((2-(6-AMINO-9H-PURIN-9-YL)-1-METHYLETHOXY)METHYL)-2,4,6,8-TETRAOXA-5-PHOSPHANONANEDIOIC ACID, BIS(1-METHYLETHYL) ESTER, 5-OXIDE, (E)-2-BUTENEDIOATE (1:1)
Common Name English
VIREA
Brand Name English
TDF
Common Name English
9-((R)-2-((BIS(((ISOPROPOXYCARBONYL)OXY)METHOXY)PHOSPHINYL)METHOXY)PROPYL)ADENINE FUMARATE (1:1)
Common Name English
Classification Tree Code System Code
EMA ASSESSMENT REPORTS VIREAD (AUTHORIZED: HEPTATITS B, CHRONIC)
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
NCI_THESAURUS C97452
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
EU-Orphan Drug EU/3/14/1419
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
EMA ASSESSMENT REPORTS EVIPLERA (AUTHORIZED: HIV INFECTIONS)
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
FDA ORPHAN DRUG 538416
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
EMA ASSESSMENT REPORTS ATRIPLA (AUTHORIZED: HIV INFECTIONS)
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
FDA ORPHAN DRUG 559316
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
EMA ASSESSMENT REPORTS TRUVADA (AUTHORIZED: HIV INFECTIONS)
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
WHO-ESSENTIAL MEDICINES LIST 6.4.2.1
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
EMA ASSESSMENT REPORTS VIREAD (AUTHORIZED: HIV INFECTIONS)
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
Code System Code Type Description
CAS
202138-50-9
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
PRIMARY
MERCK INDEX
m10559
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
PRIMARY Merck Index
CHEBI
63717
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
PRIMARY
RXCUI
322248
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
PRIMARY RxNorm
EPA CompTox
DTXSID5050426
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
TENOFOVIR DISOPROXIL FUMARATE
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
PRIMARY Description: White to almost-white, crystalline powder. Solubility: Slightly soluble in water, soluble in methanol, very slightly soluble in dichloromethane. Category: Antiretroviral (Nucleotide Reverse Transcriptase Inhibitor). Storage: Tenofovir disoproxil fumarate should be kept in a tightly closed container, protected from light and stored at a temperature between 2?8 ?C. Additional information: Tenofovir disoproxil fumarate may exhibit polymorphism. Definition: Tenofovir disoproxil fumarate contains not less than 98.5% and not more than 101.0% of tenofovir disoproxil fumarate(C19H30N5O10P,C4H4O4), calculated with reference to the anhydrous substance. Manufacture: The production method is validated to ensure that the substance, if tested, would comply with: ? a limit of not more than 5 ppm for the mutagenic impurity 9-propenyladenine (impurity K), which may be a synthesis related substance, using a suitable method; ? a limit of not more than 1.0% for the tenofovir disoproxil (S)-enantiomer (impurity G) using a suitable chiral chromatographic method.
DAILYMED
OTT9J7900I
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
PRIMARY
NCI_THESAURUS
C47747
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
PRIMARY
EVMPD
SUB12607MIG
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
PRIMARY
SMS_ID
100000092141
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
PRIMARY
PUBCHEM
6398764
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
PRIMARY
CHEBI
63718
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
PRIMARY
USAN
KK-89
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
PRIMARY
DRUG BANK
DBSALT000172
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
PRIMARY
RS_ITEM_NUM
1643656
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
PRIMARY
FDA UNII
OTT9J7900I
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
PRIMARY
ChEMBL
CHEMBL1538
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
PRIMARY
HSDB
7165
Created by admin on Fri Dec 15 15:28:20 UTC 2023 , Edited by admin on Fri Dec 15 15:28:20 UTC 2023
PRIMARY
PARENT (SALT/SOLVATE)
Structure of TENOFOVIR DISOPROXIL
NIH
NCATS
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