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Details

Stereochemistry ABSOLUTE
Molecular Formula C21H22F2N6O2
Molecular Weight 428.4352
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LAROTRECTINIB

SMILES

O[C@H]1CCN(C1)C(=O)NC2=C3N=C(C=CN3N=C2)N4CCC[C@@H]4C5=C(F)C=CC(F)=C5

InChI

InChIKey=NYNZQNWKBKUAII-KBXCAEBGSA-N
InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1

HIDE SMILES / InChI

Approval Year

Unknown
86413
Name Type Language
LAROTRECTINIB
INN   USAN   WHO-DD  
INN   USAN  
Official Name English
BAY-2757556
Code English
LOXO-101
Code English
ARRY-470
Code English
LAROTRECTINIB [USAN]
Common Name English
1-PYRROLIDINECARBOXAMIDE, N-(5-((2R)-2-(2,5-DIFLUOROPHENYL)-1-PYRROLIDINYL)PYRAZOLO(1,5-A)PYRIMIDIN-3-YL)-3-HYDROXY-, (3S)-
Systematic Name English
larotrectinib [INN]
Common Name English
Larotrectinib [WHO-DD]
Common Name English
(3S)-N-(5-((2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDIN- 1-YL)PYRAZOLO(1,5-A)PYRIMIDIN-3-YL)-3-HYDROXYPYRROLIDINE- 1-CARBOXAMIDE
Systematic Name English
LAROTRECTINIB [MI]
Common Name English
BAY2757556
Code English
Classification Tree Code System Code
NCI_THESAURUS C129825
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
FDA ORPHAN DRUG 578317
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
NCI_THESAURUS C1967
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
EU-Orphan Drug EU/3/18/2098
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
Code System Code Type Description
DRUG BANK
DB14723
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
PRIMARY
CAS
1223403-58-4
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
PRIMARY
MANUFACTURER PRODUCT INFORMATION
LOXO-101
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
PRIMARY MedKoo CAT NO: 206207CAS NO: 1223403-58-4Description: LOXO-101, also known as ARRY-470, is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC. LOXO-101 has IC50 values in the low nanomolar range for inhibition of all three TRK family members in binding and cellular assays, with 100x selectivity over other kinases, and has shown acceptable pharmaceutical properties and safety in nonclinical models. The TRK family of neurotrophin receptors, TRKA, TRKB, and TRKC (encoded by NTRK1, NTRK2, and NTRK3 genes, respectively) and their neurotrophin ligands regulate growth, differentiation and survival of neurons. (Last updated: 6/9/2016).
DRUG CENTRAL
5305
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
PRIMARY
EPA CompTox
DTXSID101020707
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
PRIMARY
NCI_THESAURUS
C115977
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
PRIMARY
FDA UNII
PF9462I9HX
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
PRIMARY
ChEMBL
CHEMBL3545075
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
PRIMARY
MERCK INDEX
m12207
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
PRIMARY
PUBCHEM
46188928
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
PRIMARY
SMS_ID
100000174559
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
PRIMARY
RXCUI
2105628
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
PRIMARY
DAILYMED
PF9462I9HX
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
PRIMARY
USAN
DE-156
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
PRIMARY
MANUFACTURER PRODUCT INFORMATION
ARRY 470
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
PRIMARY Biological Activity: LOXO-101 is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC. LOXO-101 has IC50 values in the low nanomolar range for inhibition of all three TRK family members in binding and cellular assays, with 100x selectivity over other kinases, and has shown acceptable pharmaceutical properties and safety in nonclinical models. The TRK family of neurotrophin receptors, TRKA, TRKB, and TRKC (encoded by NTRK1, NTRK2, and NTRK3 genes, respectively) and their neurotrophin ligands regulate growth, differentiation and survival of neurons. Translocations involving the TRK kinase domain, mutations involving the TRK ligand-binding site, amplifications of NTRK, TRK splice variants, and autocrine/paracrine signaling are described in diverse tumor types, and may contribute to tumorigenesis. LOXO-101 is currently being developed by Loxo Oncology, Inc.
INN
10360
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
PRIMARY
WIKIPEDIA
Larotrectinib
Created by admin on Sat Dec 16 09:51:57 UTC 2023 , Edited by admin on Sat Dec 16 09:51:57 UTC 2023
PRIMARY
ACTIVE MOIETY
Structure of LAROTRECTINIB
SALT/SOLVATE (PARENT)
Structure of Larotrectinib hydrochloride
SALT/SOLVATE (PARENT)
Structure of LAROTRECTINIB SULFATE
NIH
NCATS
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