RASAGILINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C12H13N
Molecular Weight	171.2383
Optical Activity	( + )
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of RASAGILINE

Structure Search

SMILES

C#CCN[C@@H]1CCC2=CC=CC=C12

InChI

InChIKey=RUOKEQAAGRXIBM-GFCCVEGCSA-N

InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C12H13N
Molecular Weight	171.2383
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:28:14 UTC 2023` Edited by `admin` on `Fri Dec 15 16:28:14 UTC 2023`
Record UNII	003N66TS6T
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

RASAGILINE

Official Name

English

1H-INDEN-1-AMINE, 2,3-DIHYDRO-N-2-PROPYN-1-YL-, (1R)-

Systematic Name

English

AGN-1135

Code

English

NSC-759639

Code

English

rasagiline [INN]

Common Name

English

RASAGILINE [HSDB]

Common Name

English

RASAGILINE [ORANGE BOOK]

Common Name

English

(R)-(+)-RASAGILINE

Common Name

English

RASAGILINE [VANDF]

Common Name

English

TV-1030

Code

English

(1R)-2,3-DIHYDRO-N-2-PROPYN-1-YL-1H-INDEN-1-AMINE

Systematic Name

English

1H-INDEN-1-AMINE, 2,3-DIHYDRO-N-2-PROPYNYL-, (R)-

Systematic Name

English

RASAGILINE [MI]

Common Name

English

RASAGILINE [EMA EPAR]

Common Name

English

1H-INDEN-1-AMINE, 2,3-DIHYDRO-N-2-PROPYNYL-, (1R)-

Systematic Name

English

Rasagiline [WHO-DD]

Common Name

English

RASAGILINE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C38149

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

WHO-ATC

N04BD02

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

NDF-RT

N0000175744

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

LIVERTOX

NBK547919

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

NDF-RT

N0000000184

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

NCI_THESAURUS

C667

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

WHO-VATC

QN04BD02

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

Code System Code Type Description

MERCK INDEX

m9504

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

Merck Index

EVMPD

SUB10261MIG

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

RXCUI

134748

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

RxNorm

CAS

136236-51-6

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

FDA UNII

003N66TS6T

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

EPA CompTox

DTXSID3041112

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

INN

7151

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

CHEBI

63620

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

WIKIPEDIA

RASAGILINE

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

MESH

C031967

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

PUBCHEM

3052776

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

DRUG BANK

DB01367

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

DAILYMED

003N66TS6T

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

IUPHAR

6641

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

HSDB

7699

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

LACTMED

Rasagiline

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

ChEMBL

CHEMBL887

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

NCI_THESAURUS

C66510

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

DRUG CENTRAL

3521

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

USAN

YY-124

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

NSC

759639

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

SMS_ID

100000089182

Created by admin on Fri Dec 15 16:28:14 UTC 2023 , Edited by admin on Fri Dec 15 16:28:14 UTC 2023

PRIMARY

Related Record Type Details


					2V1ZE3067R

RASAGILINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					D585ZZT7KD

RASAGILINE BESYLATE

SALT/SOLVATE -> PARENT

Amount:


					VK4SQL11C0

CYTOCHROME P450 1A2

METABOLIC ENZYME -> SUBSTRATE


					B9A329CN07

RASAGILINE TARTRATE

SALT/SOLVATE -> PARENT

Amount:


					LH8C2JI290

RASAGILINE MESYLATE

SALT/SOLVATE -> PARENT

Amount:


					3OV8HVI592

AMINE OXIDASE (FLAVIN-CONTAINING) B

TARGET -> INHIBITOR

Amount:


					UZ2TR4YN26

Rasagiline, (±)-

RACEMATE -> ENANTIOMER

Amount:

Related Record Type Details


					LHG5BD7LOR

1-INDANOL

METABOLITE -> PARENT


					NMJ8FT6NCD

1H-INDEN-1-ONE, 3-AMINO-2,3-DIHYDRO-, (3R)-

METABOLITE -> PARENT

Amount:


					AWC4KM8D9M

2,3-Dihydro-3-(2-propyn-1-ylamino)-1H-inden-1-one, (3R)-

METABOLITE -> PARENT

Amount:


					KQ9RMG9C52

METABOLITE -> PARENT


					4KF79P7GXS

2,3-DIHYDRO-3-(2-PROPYN-1-YLAMINO)-1H-INDEN-1-OL, (3R)-

METABOLITE -> PARENT


					6458TJ4BJX

(3R)-3-AMINO-2,3-DIHYDRO-1H-INDEN-1-OL

METABOLITE -> PARENT


					I17RC77CJ2

1-AMINOINDANE, (R)-

METABOLITE -> PARENT

Comments:

major metabolite, 1(R)-aminoindan, which is not an MAO inhibitor, has been therapeutically active in animal models relevant to Parkinson?s disease

Interaction Type:

MAJOR

Qualification:

PLASMA


					V7021Y717I

METABOLITE -> PARENT

Amount:


					ADC7LAW2NM

((3R)-3-(PROP-2-YNYLAMINO)INDAN-1-YL) DIHYDROGEN PHOSPHATE

METABOLITE -> PARENT


					BPD3BB6BEX

3-OH-AAI

METABOLITE -> PARENT


					I17RC77CJ2

1-AMINOINDANE, (R)-

METABOLITE -> PARENT

Comments:

In vitro experiments indicate that both routes of rasagiline metabolism are dependent on the cytochrome P450 (CYP) system, with CYP1A2 being the major isoenzyme involved in rasagiline metabolism

Amount:

Related Record Type Details


					003N66TS6T

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Tmax	PHARMACOKINETIC