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Details

Stereochemistry RACEMIC
Molecular Formula C24H26N2O4
Molecular Weight 406.4742
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CARVEDILOL

SMILES

COC1=C(OCCNCC(O)COC2=CC=CC3=C2C4=C(N3)C=CC=C4)C=CC=C1

InChI

InChIKey=OGHNVEJMJSYVRP-UHFFFAOYSA-N
InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3

HIDE SMILES / InChI
Molecular Formula C24H26N2O4
Molecular Weight 406.4742
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 14:57:34 UTC 2023
Edited
by admin
on Fri Dec 15 14:57:34 UTC 2023
Record UNII
0K47UL67F2
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CARVEDILOL
EP   HSDB   INN   JAN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
INN   USAN  
Official Name English
CARVEDILOL [VANDF]
Common Name English
CARVEDILOL [USAN]
Common Name English
BM-14.190
Code English
NSC-758694
Code English
KREDEX
Brand Name English
2-PROPANOL, 1-(9H-CARBAZOL-4-YLOXY)-3-((2-(2-METHOXYPHENOXY)ETHYL)AMINO)-, (±)-
Systematic Name English
TALLITON
Common Name English
CARVEDILOL [MI]
Common Name English
CARVEDILOL [ORANGE BOOK]
Common Name English
CORONIS
Common Name English
BM 14.190
Code English
DILATREND
Brand Name English
Carvedilol [WHO-DD]
Common Name English
C07AG02
Code English
CARVEDILOL [MART.]
Common Name English
SKF-105517
Code English
COREG
Brand Name English
1-(CARBAZOL-4-YLOXY)-3-((2-(O-METHOXY-PHENOXY)ETHYL)AMINO)-2-PROPANOL
Common Name English
KORVASAN
Common Name English
CARVEDILOL [HSDB]
Common Name English
DQ-2466
Code English
CARVEDILOL [EP MONOGRAPH]
Common Name English
ARTIST
Brand Name English
DIMITONE
Brand Name English
CARVEDILOL [JAN]
Common Name English
EUCARDIC
Brand Name English
CARVEDILOL [USP-RS]
Common Name English
BM-14190
Code English
BM-14-190
Code English
SK&F-105517
Code English
QUERTO
Brand Name English
(±)-1-CARBAZOL-4-YLOXY)-3-((2-(O-METHOXYPHENOXY)ETHYL)AMINO)-2-PROPANOL
Common Name English
carvedilol [INN]
Common Name English
CARVEDILOL [USP MONOGRAPH]
Common Name English
Classification Tree Code System Code
NDF-RT N0000009923
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
NDF-RT N0000175556
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
WHO-ATC C07FX06
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
LIVERTOX NBK548399
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
NDF-RT N0000175553
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
WHO-VATC QC07AG02
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
NDF-RT N0000009924
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
NCI_THESAURUS C29576
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
WHO-ATC C07AG02
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
NDF-RT N0000000099
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
Code System Code Type Description
ChEMBL
CHEMBL723
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
EPA CompTox
DTXSID8022747
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
DAILYMED
0K47UL67F2
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
RS_ITEM_NUM
1096622
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
MESH
C043211
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
NCI_THESAURUS
C28906
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
DRUG BANK
DB01136
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
LACTMED
Carvedilol
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
DRUG CENTRAL
522
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
JAPANESE REVIEW
ARTIST
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY APPROVED AUGUST 2015
RXCUI
20352
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY RxNorm
EVMPD
SUB06153MIG
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
IUPHAR
551
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
NSC
758694
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
MERCK INDEX
m3143
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY Merck Index
FDA UNII
0K47UL67F2
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
HSDB
7044
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
USAN
Z-25
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
WIKIPEDIA
Carvedilol
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
PUBCHEM
2585
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
INN
5333
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
CAS
72956-09-3
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
CHEBI
3441
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
SMS_ID
100000092577
Created by admin on Fri Dec 15 14:57:34 UTC 2023 , Edited by admin on Fri Dec 15 14:57:34 UTC 2023
PRIMARY
Related Record Type Details
Structure of CARVEDILOL PHOSPHATE
SALT/SOLVATE -> PARENT
CYTOCHROME P450 2D6
METABOLIC ENZYME -> SUBSTRATE
Structure of CARVEDILOL PHOSPHATE MONOHYDRATE
SALT/SOLVATE -> PARENT
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
Structure of CARVEDILOL, (+)-
ENANTIOMER -> RACEMATE
CYTOCHROME P450 1A2
METABOLIC ENZYME -> SUBSTRATE
MAJOR
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
Structure of CARVEDILOL
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
EP
OCT-2
TRANSPORTER -> INHIBITOR
CYTOCHROME P450 2C9
METABOLIC ENZYME -> SUBSTRATE
MULTIDRUG RESISTANCE PROTEIN 1
TRANSPORTER -> INHIBITOR
CYTOCHROME P450 2E1
METABOLIC ENZYME -> SUBSTRATE
Structure of CARVEDILOL, (-)-
ENANTIOMER -> RACEMATE
Structure of CARVEDILOL
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
USP
BETA-1 ADRENERGIC RECEPTOR
TARGET -> AGONIST
Structure of CARVEDILOL HYDROCHLORIDE
SALT/SOLVATE -> PARENT
BETA-1 ADRENERGIC RECEPTOR
TARGET -> INHIBITOR
Related Record Type Details
Structure of O-DESMETHYLCARVEDILOL
METABOLITE ACTIVE -> PARENT
PLASMA
Structure of CARVEDILOL GLUCURONIDE
METABOLITE -> PARENT
MAJOR
URINE
Structure of 4-HYDROXYCARVEDILOL
METABOLITE ACTIVE -> PARENT
Structure of 4-HYDROXYCARVEDILOL
METABOLITE ACTIVE -> PARENT
Related Record Type Details
Structure of 2-(2-METHOXYPHENOXY)ETHYL AMINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 1-(4-(2-HYDROXY-3-(2-(2-METHOXYPHENOXY)ETHYLAMINO)PROPOXY)-9H-CARBAZOL-9-YL)-3-(2-(2-METHOXYPHENOXY)ETHYLAMINO) PROPAN-2-OL
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 1-(9H-CARBAZOL-4-YLOXY)-3-(4-(2-HYDROXY-3-((2-(2-METHOXYPHENOXY)ETHYL)AMINO)PROPOXY)-9H-CARBAZOL-9-YL)PROPAN-2-OL
IMPURITY -> PARENT
Structure of 1-(4-(2-HYDROXY-3-(2-(2-METHOXYPHENOXY)ETHYLAMINO)PROPOXY)-9H-CARBAZOL-9-YL)-3-(2-(2-METHOXYPHENOXY)ETHYLAMINO) PROPAN-2-OL
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 4-OXIRANYLMETHOXY-9H-CARBAZOLE
IMPURITY -> PARENT
Structure of N-BENZYLCARVEDILOL
IMPURITY -> PARENT
Structure of 4-OXIRANYLMETHOXY-9H-CARBAZOLE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of N-BENZYLCARVEDILOL
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of N-METHYL CARVEDILOL
IMPURITY -> PARENT
Structure of 3,3'-(((1,2-PHENYLENEBIS(OXY))BIS(ETHANE-2,1-DIYL))BIS(AZANEDIYL))BIS(1-((9H-CARBAZOL-4-YL)OXY)PROPAN-2-OL)
IMPURITY -> PARENT
Structure of 1-(9H-CARBAZOL-4-YLOXY)-3-(4-(2-HYDROXY-3-((2-(2-METHOXYPHENOXY)ETHYL)AMINO)PROPOXY)-9H-CARBAZOL-9-YL)PROPAN-2-OL
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of N-Isopropyl Carvedilol
IMPURITY -> PARENT
Structure of 2-(2-METHOXYPHENOXY)ETHYL AMINE
IMPURITY -> PARENT
Structure of 3,3'-(2-(2-METHOXYPHENOXY)ETHYLAZANEDIYL)BIS(1-(9H-CARBAZOL-4-YLOXY)PROPAN-2-OL)
IMPURITY -> PARENT
Structure of N-BENZYLCARVEDILOL
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 1-(4-(2-HYDROXY-3-(2-(2-METHOXYPHENOXY)ETHYLAMINO)PROPOXY)-9H-CARBAZOL-9-YL)-3-(2-(2-METHOXYPHENOXY)ETHYLAMINO) PROPAN-2-OL
IMPURITY -> PARENT
Related Record Type Details
Structure of CARVEDILOL
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
MAXIMUM TOLERATED DOSE TOXICITY HEART FAILURE, MORE THAN 85 kg

HEART FAILURE, LESS THAN 85 kg

Volume of Distribution PHARMACOKINETIC
ORAL BIOAVAILABILITY PHARMACOKINETIC
NIH
NCATS
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