DSM-265

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NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H12F7N5S
Molecular Weight	415.332
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DSM-265

Structure Search

SMILES

CC1=NC2=NC(=NN2C(NC3=CC=C(C=C3)S(F)(F)(F)(F)F)=C1)C(C)(F)F

InChI

InChIKey=OIZSVTOIBNSVOS-UHFFFAOYSA-N

InChI=1S/C14H12F7N5S/c1-8-7-11(26-13(22-8)24-12(25-26)14(2,15)16)23-9-3-5-10(6-4-9)27(17,18,19,20)21/h3-7,23H,1-2H3

HIDE SMILES / InChI

Molecular Formula	C14H12F7N5S
Molecular Weight	415.332
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:44:49 UTC 2023` Edited by `admin` on `Sat Dec 16 11:44:49 UTC 2023`
Record UNII	0Q42P4YI6B
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DSM-265

Common Name

English

2-(1,1-DIFLUOROETHYL)-5-METHYL-N-(4-(PENTAFLUORO-.LAMBDA.6-SULFANYL)PHENYL) (1,2,4)TRIAZOLO(1,5-A)PYRIMIDIN-7-AMINE

Systematic Name

English

SULFUR, (4-((2-(1,1-DIFLUOROETHYL)-5-METHYL(1,2,4)TRIAZOLO(1,5-A)PYRIMIDIN-7-YL)AMINO)PHENYL)PENTAFLUORO-, (OC-6-21)-

Systematic Name

English

DSM265

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

598417

Created by admin on Sat Dec 16 11:44:49 UTC 2023 , Edited by admin on Sat Dec 16 11:44:49 UTC 2023

Code System Code Type Description

PUBCHEM

51347395

Created by admin on Sat Dec 16 11:44:49 UTC 2023 , Edited by admin on Sat Dec 16 11:44:49 UTC 2023

PRIMARY

FDA UNII

0Q42P4YI6B

Created by admin on Sat Dec 16 11:44:49 UTC 2023 , Edited by admin on Sat Dec 16 11:44:49 UTC 2023

PRIMARY

CAS

1282041-94-4

Created by admin on Sat Dec 16 11:44:49 UTC 2023 , Edited by admin on Sat Dec 16 11:44:49 UTC 2023

PRIMARY

DRUG BANK

DB12397

Created by admin on Sat Dec 16 11:44:49 UTC 2023 , Edited by admin on Sat Dec 16 11:44:49 UTC 2023

PRIMARY

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PLASMODIUM VIVAX

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TARGET ORGANISM->INHIBITOR

Comments:

DSM265 displayed maximum antimalarial effects at 3 × EC50 and above, requiring a 24- to 48-hour lag phase before parasite killing. At 1 × EC50, DSM265 parasite killing was further delayed (96-hour lag phase).

Qualification:

EC50

Amount:

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DSM-265

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC