PILOCARPINE HYDROCHLORIDE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C11H16N2O2.ClH
Molecular Weight	244.718
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PILOCARPINE HYDROCHLORIDE

Structure Search

SMILES

Cl.CC[C@H]1[C@@H](CC2=CN=CN2C)COC1=O

InChI

InChIKey=RNAICSBVACLLGM-GNAZCLTHSA-N

InChI=1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;/h5,7-8,10H,3-4,6H2,1-2H3;1H/t8-,10-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	C11H16N2O2
Molecular Weight	208.2569
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:14:43 UTC 2023` Edited by `admin` on `Fri Dec 15 15:14:43 UTC 2023`
Record UNII	0WW6D218XJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PILOCARPINE HYDROCHLORIDE

Common Name

English

2(3H)-FURANONE, 3-ETHYLDIHYDRO-4-((1-METHYL-1H-IMIDAZOL-5-YL)METHYL)-, MONOHYDROCHLORIDE, (3S,4R)-

Common Name

English

SALAGEN

Common Name

English

PILOCARPINE HCL

Common Name

English

PILOCARPINI HYDROCHLORIDUM [WHO-IP LATIN]

Common Name

English

PILOCARPINUM MURIATICUM [HPUS]

Common Name

English

PILOCARPINE HYDROCHLORIDE [USP-RS]

Common Name

English

VUITY

Brand Name

English

PILOCARPINE HYDROCHLORIDE COMPONENT OF BETOPTIC PILO

Common Name

English

PILOCARPINE HYDROCHLORIDE [JAN]

Common Name

English

PILOCARPINE HYDROCHLORIDE [MART.]

Common Name

English

PILOPINE HS

Brand Name

English

PILOCARPINE HYDROCHLORIDE [MI]

Common Name

English

PILOPINE

Brand Name

English

(3S,4R)-3-ETHYL-4-((1-METHYL-1H-IMIDAZOL-5-YL)METHYL)DIHYDROFURAN-2(3H)-ONE HYDROCHLORIDE

Systematic Name

English

PILOCARPINE HYDROCHLORIDE [ORANGE BOOK]

Common Name

English

Pilocarpine monohydrochloride

Common Name

English

PILOCARPINE HYDROCHLORIDE [USP IMPURITY]

Common Name

English

PILOCARPINE HYDROCHLORIDE [EP IMPURITY]

Common Name

English

PILOCARPINE HYDROCHLORIDE [USP MONOGRAPH]

Common Name

English

PILOCARPINE HCL [VANDF]

Common Name

English

Pilocarpine hydrochloride [WHO-DD]

Common Name

English

PILOCARPINE HYDROCHLORIDE [VANDF]

Common Name

English

PILOCARPINE HYDROCHLORIDE [EP MONOGRAPH]

Common Name

English

PILOCARPINUM MURIATICUM

Common Name

English

ALMOCARPINE

Common Name

English

BETOPTIC PILO COMPONENT PILOCARPINE HYDROCHLORIDE

Common Name

English

2(3H)-FURANONE, 3-ETHYLDIHYDRO-4-((1-METHYL-1H-IMIDAZOL-5-YL)METHYL)-, MONOHYDROCHLORIDE, (3S-CIS)-

Common Name

English

PILOCARPINE HYDROCHLORIDE [WHO-IP]

Common Name

English

VISTACARPIN N

Common Name

English

QLOSI

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47796

Created by admin on Fri Dec 15 15:14:43 UTC 2023 , Edited by admin on Fri Dec 15 15:14:43 UTC 2023

FDA ORPHAN DRUG

62091

Created by admin on Fri Dec 15 15:14:43 UTC 2023 , Edited by admin on Fri Dec 15 15:14:43 UTC 2023

Code System Code Type Description

MERCK INDEX

m8806

Created by admin on Fri Dec 15 15:14:43 UTC 2023 , Edited by admin on Fri Dec 15 15:14:43 UTC 2023

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Merck Index

DAILYMED

0WW6D218XJ

Created by admin on Fri Dec 15 15:14:43 UTC 2023 , Edited by admin on Fri Dec 15 15:14:43 UTC 2023

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PUBCHEM

5909

Created by admin on Fri Dec 15 15:14:43 UTC 2023 , Edited by admin on Fri Dec 15 15:14:43 UTC 2023

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NCI_THESAURUS

C748

Created by admin on Fri Dec 15 15:14:43 UTC 2023 , Edited by admin on Fri Dec 15 15:14:43 UTC 2023

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ECHA (EC/EINECS)

200-212-5

Created by admin on Fri Dec 15 15:14:43 UTC 2023 , Edited by admin on Fri Dec 15 15:14:43 UTC 2023

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EVMPD

SUB14870MIG

Created by admin on Fri Dec 15 15:14:43 UTC 2023 , Edited by admin on Fri Dec 15 15:14:43 UTC 2023

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DRUG BANK

DBSALT000307

Created by admin on Fri Dec 15 15:14:43 UTC 2023 , Edited by admin on Fri Dec 15 15:14:43 UTC 2023

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ChEMBL

CHEMBL550

Created by admin on Fri Dec 15 15:14:43 UTC 2023 , Edited by admin on Fri Dec 15 15:14:43 UTC 2023

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CHEBI

141029

Created by admin on Fri Dec 15 15:14:43 UTC 2023 , Edited by admin on Fri Dec 15 15:14:43 UTC 2023

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RS_ITEM_NUM

1538902

Created by admin on Fri Dec 15 15:14:43 UTC 2023 , Edited by admin on Fri Dec 15 15:14:43 UTC 2023

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RXCUI

235426

Created by admin on Fri Dec 15 15:14:43 UTC 2023 , Edited by admin on Fri Dec 15 15:14:43 UTC 2023

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RxNorm

EPA CompTox

DTXSID2041096

Created by admin on Fri Dec 15 15:14:43 UTC 2023 , Edited by admin on Fri Dec 15 15:14:43 UTC 2023

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WHO INTERNATIONAL PHARMACOPEIA

PILOCARPINE HYDROCHLORIDE

Created by admin on Fri Dec 15 15:14:43 UTC 2023 , Edited by admin on Fri Dec 15 15:14:43 UTC 2023

PRIMARY

Description: Colourless crystals or a white, crystalline powder; odourless or almost odourless. Solubility: Very soluble in water; freely soluble in ethanol (~750 g/l) TS; insoluble in ether R. Category: Parasympathomimetic; miotic. Storage: Pilocarpine hydrochloride should be kept in a tightly closed container, protected from light. Additional information: Pilocarpine hydrochloride is very poisonous; it is hygroscopic and is affected by light. Even in the absenceof light, Pilocarpine hydrochloride is gradually degraded on exposure to a humid atmosphere, the decomposition being faster athigher temperatures. Definition: Pilocarpine hydrochloride contains not less than 98.5% and not more than 101.0% of C11H16N2O2,HCl, calculated withreference to the dried substance.

FDA UNII

0WW6D218XJ

Created by admin on Fri Dec 15 15:14:43 UTC 2023 , Edited by admin on Fri Dec 15 15:14:43 UTC 2023

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CAS

54-71-7

Created by admin on Fri Dec 15 15:14:43 UTC 2023 , Edited by admin on Fri Dec 15 15:14:43 UTC 2023

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SMS_ID

100000091736

Created by admin on Fri Dec 15 15:14:43 UTC 2023 , Edited by admin on Fri Dec 15 15:14:43 UTC 2023

PRIMARY

Related Record Type Details


					0WW6D218XJ

PILOCARPINE HYDROCHLORIDE

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (HPLC)

Qualification:

USP

Amount:


					01MI4Q9DI3

PARENT -> SALT/SOLVATE

Amount:


					0WW6D218XJ

PILOCARPINE HYDROCHLORIDE

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (TITRATION)

Qualification:

EP

Amount:

Related Record Type Details


					VML9DTP0QW

ISOPILOCARPIC ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					978XN1E1ZN

PILOCARPIC ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					978XN1E1ZN

PILOCARPIC ACID

IMPURITY -> PARENT

Comments:

sum of impurities A and B: not more than 3 times the area of the principal peak in the chromatogram obtained with reference solution (a) (1.5 per cent)

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					J9UV7D2OI9

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					J9UV7D2OI9

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					VML9DTP0QW

ISOPILOCARPIC ACID

IMPURITY -> PARENT

Comments:

UNSPECIFIED

Qualification:

EP

Related Record Type Details


					01MI4Q9DI3

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Other	PHARMACOKINETIC				Cmax PHARMACOKINETIC

Other	PHARMACOKINETIC				Doses PHARMACOKINETIC