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Details

Stereochemistry ACHIRAL
Molecular Formula C16H18FN3O2
Molecular Weight 303.3314
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of EZOGABINE

SMILES

CCOC(=O)NC1=CC=C(NCC2=CC=C(F)C=C2)C=C1N

InChI

InChIKey=PCOBBVZJEWWZFR-UHFFFAOYSA-N
InChI=1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21)

HIDE SMILES / InChI
Molecular Formula C16H18FN3O2
Molecular Weight 303.3314
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Sat Dec 16 16:54:04 UTC 2023
Edited
by admin
on Sat Dec 16 16:54:04 UTC 2023
Record UNII
12G01I6BBU
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EZOGABINE
DASH   MI   ORANGE BOOK   USAN   VANDF  
USAN  
Official Name English
RETIGABINE
EMA EPAR   INN   MART.   WHO-DD  
INN  
Official Name English
Retigabine [WHO-DD]
Common Name English
POTIGA
Brand Name English
AWD-21360
Code English
XEN-496
Code English
GW582892X
Code English
EZOGABINE [MI]
Common Name English
TROBALT
Brand Name English
GKE-841
Code English
EZOGABINE [VANDF]
Common Name English
GW-582892X
Code English
RETIGABINE [MART.]
Common Name English
retigabine [INN]
Common Name English
AWD21-360
Code English
CARBAMIC ACID, (2-AMINO-4-(((4-FLUORO-PHENYL)METHYL)AMINO)PHENYL)-ETHYL ESTER
Systematic Name English
RETIGABINE [EMA EPAR]
Common Name English
XEN496
Code English
D-23129
Code English
WAY-143841
Code English
EZOGABINE [ORANGE BOOK]
Common Name English
N-[2-Amino-4-(4-fluorobenzylamino)-phenyl]carbamic acid ethyl ester
Systematic Name English
EZOGABINE [USAN]
Common Name English
Classification Tree Code System Code
NDF-RT N0000182729
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
DEA NO. 2779
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
EMA ASSESSMENT REPORTS TROBALT (AUTHORIZED: EPILEPSY)
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
FDA ORPHAN DRUG 639118
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
WHO-VATC QN03AX21
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
NCI_THESAURUS C264
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
WHO-ATC N03AX21
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
LIVERTOX NBK548304
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
Code System Code Type Description
PUBCHEM
121892
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY
MERCK INDEX
m5229
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY Merck Index
HSDB
8171
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY
WIKIPEDIA
Retigabine
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY
IUPHAR
2601
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY
LACTMED
Ezogabine
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY
INN
7545
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY
CHEBI
68584
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY
SMS_ID
100000080573
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY
CAS
150812-12-7
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY
USAN
SS-10
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY
DRUG CENTRAL
4181
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY
NCI_THESAURUS
C72839
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY
EVMPD
SUB10291MIG
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY
RXCUI
1112990
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY RxNorm
NDF-RT
N0000182728
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY Potassium Channel Openers [MoA]
EPA CompTox
DTXSID40164615
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY
DRUG BANK
DB04953
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY
ChEMBL
CHEMBL41355
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY
FDA UNII
12G01I6BBU
Created by admin on Sat Dec 16 16:54:06 UTC 2023 , Edited by admin on Sat Dec 16 16:54:06 UTC 2023
PRIMARY
Related Record Type Details
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A4
METABOLIC ENZYME -> SUBSTRATE
Structure of EZOGABINE DIHYDROCHLORIDE
SALT/SOLVATE -> PARENT
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A1
METABOLIC ENZYME -> SUBSTRATE
Structure of EZOGABINE
EXCRETED UNCHANGED
URINE
Structure of EZOGABINE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A3
METABOLIC ENZYME -> SUBSTRATE
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2
TARGET->STABILIZER
ARYLAMINE N-ACETYLTRANSFERASE 2
METABOLIC ENZYME -> SUBSTRATE
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 3
TARGET->STABILIZER
Related Record Type Details
Structure of (2S,3S,4S,5R)-6-(2-(ETHOXYCARBONYLAMINO)-5-((4-FLUOROPHENYL)METHYLAMINO)ANILINO)-3,4,5-TRIHYDROXY-TETRAHYDROPYRAN-2-CARBOXYLIC ACID
METABOLITE -> PARENT
MAJOR
Structure of (2S,3S,4S,5R)-6-(2-ACETAMIDO-5-((4-FLUOROPHENYL)METHYLAMINO)ANILINO)-3,4,5-TRIHYDROXY-TETRAHYDROPYRAN-2-CARBOXYLIC ACID
METABOLITE -> PARENT
Structure of CARBAMIC ACID, (4-(((4-FLUOROPHENYL)METHYL)AMINO)-2-(.BETA.-D-GLUCOPYRANOSYLAMINO)PHENYL)-, ETHYL ESTER
METABOLITE -> PARENT
MAJOR
Structure of (2S,3S,4S,5R)-6-(4-ACETAMIDO-3-AMINO-N-((4-FLUOROPHENYL)METHYL)ANILINO)-3,4,5-TRIHYDROXY-TETRAHYDROPYRAN-2-CARBOXYLIC ACID
METABOLITE -> PARENT
Related Record Type Details
Structure of EZOGABINE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Tmax PHARMACOKINETIC
ORAL BIOAVAILABILITY PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC INTRAVENOUS ADMINISTRATION

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