DIPRENORPHINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H35NO4
Molecular Weight	425.5604
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DIPRENORPHINE

Structure Search

SMILES

CO[C@]12CC[C@@]3(C[C@@H]1C(C)(C)O)[C@H]4CC5=CC=C(O)C6=C5[C@@]3(CCN4CC7CC7)[C@H]2O6

InChI

InChIKey=OIJXLIIMXHRJJH-KNLIIKEYSA-N

InChI=1S/C26H35NO4/c1-23(2,29)18-13-24-8-9-26(18,30-3)22-25(24)10-11-27(14-15-4-5-15)19(24)12-16-6-7-17(28)21(31-22)20(16)25/h6-7,15,18-19,22,28-29H,4-5,8-14H2,1-3H3/t18-,19-,22-,24-,25+,26-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C26H35NO4
Molecular Weight	425.5604
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 6
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:01:15 UTC 2023` Edited by `admin` on `Sat Dec 16 17:01:15 UTC 2023`
Record UNII	1F0L5N25ZZ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DIPRENORPHINE

Official Name

English

M-5050

Code

English

REVIVON

Brand Name

English

diprenorphine [INN]

Common Name

English

M5050

Code

English

DIPRENORPHINE [MI]

Common Name

English

M. 5050

Code

English

6,14-ETHENOMORPHINAN-7-METHANOL, 17-(CYCLOPROPYLMETHYL)-4,5-EPOXY-18,19-DIHYDRO-3-HYDROXY-6-METHOXY-.ALPHA.,.ALPHA.-DIMETHYL-, (5.ALPHA.,7.ALPHA.)-

Common Name

English

DIPRENORFIN

Common Name

English

Classification Tree Code System Code

WHO-VATC

QV03AB92

Created by admin on Sat Dec 16 17:01:16 UTC 2023 , Edited by admin on Sat Dec 16 17:01:16 UTC 2023

Code System Code Type Description

NCI_THESAURUS

C166495

Created by admin on Sat Dec 16 17:01:16 UTC 2023 , Edited by admin on Sat Dec 16 17:01:16 UTC 2023

PRIMARY

MESH

D004174

Created by admin on Sat Dec 16 17:01:16 UTC 2023 , Edited by admin on Sat Dec 16 17:01:16 UTC 2023

PRIMARY

PUBCHEM

443408

Created by admin on Sat Dec 16 17:01:16 UTC 2023 , Edited by admin on Sat Dec 16 17:01:16 UTC 2023

PRIMARY

DRUG BANK

DB01548

Created by admin on Sat Dec 16 17:01:16 UTC 2023 , Edited by admin on Sat Dec 16 17:01:16 UTC 2023

PRIMARY

CAS

14357-78-9

Created by admin on Sat Dec 16 17:01:16 UTC 2023 , Edited by admin on Sat Dec 16 17:01:16 UTC 2023

PRIMARY

MERCK INDEX

m4650

Created by admin on Sat Dec 16 17:01:16 UTC 2023 , Edited by admin on Sat Dec 16 17:01:16 UTC 2023

PRIMARY

Merck Index

ChEMBL

CHEMBL281786

Created by admin on Sat Dec 16 17:01:16 UTC 2023 , Edited by admin on Sat Dec 16 17:01:16 UTC 2023

PRIMARY

EPA CompTox

DTXSID00903941

Created by admin on Sat Dec 16 17:01:16 UTC 2023 , Edited by admin on Sat Dec 16 17:01:16 UTC 2023

PRIMARY

ECHA (EC/EINECS)

238-325-7

Created by admin on Sat Dec 16 17:01:16 UTC 2023 , Edited by admin on Sat Dec 16 17:01:16 UTC 2023

PRIMARY

FDA UNII

1F0L5N25ZZ

Created by admin on Sat Dec 16 17:01:16 UTC 2023 , Edited by admin on Sat Dec 16 17:01:16 UTC 2023

PRIMARY

SMS_ID

100000082351

Created by admin on Sat Dec 16 17:01:16 UTC 2023 , Edited by admin on Sat Dec 16 17:01:16 UTC 2023

PRIMARY

WIKIPEDIA

Diprenorphine

Created by admin on Sat Dec 16 17:01:16 UTC 2023 , Edited by admin on Sat Dec 16 17:01:16 UTC 2023

PRIMARY

INN

2639

Created by admin on Sat Dec 16 17:01:16 UTC 2023 , Edited by admin on Sat Dec 16 17:01:16 UTC 2023

PRIMARY

EVMPD

SUB07220MIG

Created by admin on Sat Dec 16 17:01:16 UTC 2023 , Edited by admin on Sat Dec 16 17:01:16 UTC 2023

PRIMARY

Related Record Type Details


					1PE72K8X46

MU-TYPE OPIOID RECEPTOR

TARGET -> INHIBITOR

Comments:

In contrast to naloxone, diprenorphine (0.03 mgkg−1i.p.)reversed equipotent doses of morphine and fentanyl to the same degree. Assay done on SH-SY5Y cells displacing [3H]DIPRENORPHINE.

Qualification:

Ki

Amount:


					1PE72K8X46

MU-TYPE OPIOID RECEPTOR

TARGET -> INHIBITOR

Qualification:

Ki

Amount:


					H58945J6KL

Diprenorphine H-3

LABELED -> NON-LABELED

Amount:


					EV0PWK6TT6

DELTA-TYPE OPIOID RECEPTOR

TARGET -> INHIBITOR

Comments:

Assumed Kd similar to all opioid receptors

Qualification:

Kd

Amount:


					WBS7IEP4SN

DIPRENORPHINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					2BJ58BX78W

KAPPA-TYPE OPIOID RECEPTOR

TARGET -> INHIBITOR

Comments:

Assumed Kd similar to all opioid receptors

Qualification:

Kd

Amount:

Related Record Type Details


					1F0L5N25ZZ

ACTIVE MOIETY

Amount: