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Details

Stereochemistry RACEMIC
Molecular Formula C16H18N2
Molecular Weight 238.3275
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NOMIFENSINE

SMILES

CN1CC(C2=CC=CC=C2)C3=C(C1)C(N)=CC=C3

InChI

InChIKey=XXPANQJNYNUNES-UHFFFAOYSA-N
InChI=1S/C16H18N2/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18/h2-9,14H,10-11,17H2,1H3

HIDE SMILES / InChI
Molecular Formula C16H18N2
Molecular Weight 238.3275
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Sat Dec 16 06:18:33 UTC 2023
Edited
by admin
on Sat Dec 16 06:18:33 UTC 2023
Record UNII
1LGS5JRP31
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NOMIFENSINE
HSDB   INN   MI   WHO-DD  
INN  
Official Name English
1,2,3,4-TETRAHYDRO-2-METHYL-4-PHENYL-8-ISOQUINOLINAMINE
Systematic Name English
2-METHYL-4-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLIN-8-YLAMINE
Systematic Name English
NOMIFENSINE [MI]
Common Name English
NOMIFENSINE [HSDB]
Common Name English
8-ISOQUINOLINAMINE, 1,2,3,4-TETRAHYDRO-2-METHYL-4-PHENYL-
Systematic Name English
(±)-NOMIFENSINE
Common Name English
LINAMIPHEN
Common Name English
NOMIFENSIN
Brand Name English
(±)-NOMIFENSIN
Common Name English
nomifensine [INN]
Common Name English
Nomifensine [WHO-DD]
Common Name English
ISOQUINOLINE, 8-AMINO-1,2,3,4-TETRAHYDRO-2-METHYL-4-PHENYL-
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C265
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
EPA PESTICIDE CODE 600075
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
WHO-VATC QN06AX04
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
WHO-ATC N06AX04
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
Code System Code Type Description
ChEMBL
CHEMBL273575
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
PRIMARY
FDA UNII
1LGS5JRP31
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
PRIMARY
EPA CompTox
DTXSID0023377
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
PRIMARY
CHEBI
116225
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
PRIMARY
DRUG BANK
DB04821
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
PRIMARY
INN
2920
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
PRIMARY
WIKIPEDIA
NOMIFENSINE
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
PRIMARY
DRUG CENTRAL
1958
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
PRIMARY
MESH
D009627
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
PRIMARY
EVMPD
SUB09347MIG
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
PRIMARY
NCI_THESAURUS
C72824
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
PRIMARY
HSDB
7702
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
PRIMARY
RXCUI
7500
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
PRIMARY RxNorm
PUBCHEM
4528
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
PRIMARY
CAS
24526-64-5
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
PRIMARY
MERCK INDEX
m8030
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
PRIMARY Merck Index
IUPHAR
4792
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
PRIMARY
SMS_ID
100000083568
Created by admin on Sat Dec 16 06:18:34 UTC 2023 , Edited by admin on Sat Dec 16 06:18:34 UTC 2023
PRIMARY
Related Record Type Details
CYTOCHROME P450 2B6
METABOLIC ENZYME -> SUBSTRATE
MAJOR
FETAL HEPATIC FLAVIN-CONTAINING MONOOXYGENASE 1 (HUMAN)
METABOLIC ENZYME -> SUBSTRATE
SODIUM-DEPENDENT DOPAMINE TRANSPORTER
TARGET -> INHIBITOR
Due to a risk of haemolytic anaemia, the U.S. Food and Drug Administration (FDA) withdrew approval for nomifensine on March 20, 1992. Nomifensine was subsequently withdrawn from the Canadian and UK markets as well.
BINDING
IC50
DIMETHYLANILINE MONOOXYGENASE (N-OXIDE-FORMING) 5
METABOLIC ENZYME -> SUBSTRATE
Structure of NOMIFENSINE MALEATE
SALT/SOLVATE -> PARENT
CYTOCHROME P450 2C19
METABOLIC ENZYME -> SUBSTRATE
CYTOCHROME P450 1A2
METABOLIC ENZYME -> SUBSTRATE
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METABOLIC ENZYME -> SUBSTRATE
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
MAJOR
Related Record Type Details
Structure of NOMIFENSINE N-HYDROXY
METABOLITE -> PARENT
IN VITRO
Structure of 4'-HYDROXYNOMIFENSINE
METABOLITE -> PARENT
IN VITRO
Structure of 4'-HYDROXY-3'-METHOXYNOMIFENSINE
METABOLITE -> PARENT
Structure of 3'-HYDROXY-4'-METHOXYNOMIFENSINE
METABOLITE -> PARENT
Structure of NOMIFENSINE DIHYDROISOQUINOLINIUM
METABOLITE -> PARENT
Related Record Type Details
Structure of NOMIFENSINE
ACTIVE MOIETY
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