AMBROXOL

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H18Br2N2O
Molecular Weight	378.103
Optical Activity	NONE
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of AMBROXOL

Structure Search

SMILES

NC1=C(Br)C=C(Br)C=C1CN[C@H]2CC[C@H](O)CC2

InChI

InChIKey=JBDGDEWWOUBZPM-XYPYZODXSA-N

InChI=1S/C13H18Br2N2O/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10/h5-6,10-11,17-18H,1-4,7,16H2/t10-,11-

HIDE SMILES / InChI

Molecular Formula	C13H18Br2N2O
Molecular Weight	378.103
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:43:02 UTC 2023` Edited by `admin` on `Fri Dec 15 15:43:02 UTC 2023`
Record UNII	200168S0CL
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

AMBROXOL

Official Name

English

ambroxol [INN]

Common Name

English

Ambroxol [WHO-DD]

Common Name

English

TABCIN

Brand Name

English

AMBROXOL [MI]

Common Name

English

TRANS-4-((2-AMINO-3,5-DIBROMOBENZYL)AMINO)CYCLOHEXANOL

Systematic Name

English

4-HYDROXYDEMETHYLBROMHEXINE, TRANS-

Common Name

English

Classification Tree Code System Code

WHO-ATC

R03CC63

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

FDA ORPHAN DRUG

262308

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

NCI_THESAURUS

C74536

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

NCI_THESAURUS

C29767

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

WHO-VATC

QR05CB06

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

WHO-ATC

R05CB06

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

Code System Code Type Description

DRUG CENTRAL

147

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

PRIMARY

NCI_THESAURUS

C74262

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

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MERCK INDEX

m1650

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

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Merck Index

CAS

18683-91-5

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

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RXCUI

625

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

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RxNorm

MESH

D000551

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

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EVMPD

SUB05397MIG

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

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SMS_ID

100000087650

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

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WIKIPEDIA

AMBROXOL

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

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EPA CompTox

DTXSID8022583

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

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DRUG BANK

DB06742

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

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FDA UNII

200168S0CL

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

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INN

3692

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

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ChEMBL

CHEMBL153479

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

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ECHA (EC/EINECS)

242-500-3

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

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DAILYMED

200168S0CL

Created by admin on Fri Dec 15 15:43:02 UTC 2023 , Edited by admin on Fri Dec 15 15:43:02 UTC 2023

PRIMARY

Related Record Type Details


					0HM1E174TN

AMBROXOL ACEFYLLINATE

SALT/SOLVATE -> PARENT


					CC995ZMV90

AMBROXOL HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Related Record Type Details


					Q1J152VB1P

PARENT -> METABOLITE ACTIVE

Comments:

When bromhexine is administered orally, the systemic exposure to ambroxol is much lower (;8-fold; Liu et al., 2010), but since the true molecular action of these agents is not entirely known, it cannot be ascertained whether bromhexine or ambroxol, or both, contribute to activity. Ambroxol has also been associated with a reduction in throat pain, which has triggered investigation into the activity of it and bromhexine at sodium channels (such as NaV1.8 and the tetrodotoxin sensitive channel; Leffler et al., 2010).

Interaction Type:

MAJOR

Qualification:

PLASMA

Related Record Type Details


					200168S0CL

AMBROXOL

ACTIVE MOIETY