Pomlucabtagene autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 19:33:39 UTC 2023` Edited by `admin` on `Sat Dec 16 19:33:39 UTC 2023`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BLOOD
Fraction Material Type	CELL
Fraction Name	CD3+ enriched T lymphocytes
Record UNII	22TCU7HE9E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Pomlucabtagene autoleucel

Official Name

English

autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating murine stem cell virus (MSCV) vector, encoding a chimeric antigen receptor (CAR) targeting human ganglioside

Common Name

English

pomlucabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

FDA UNII

22TCU7HE9E

Created by admin on Sat Dec 16 19:33:40 UTC 2023 , Edited by admin on Sat Dec 16 19:33:40 UTC 2023

PRIMARY

INN

12254

Created by admin on Sat Dec 16 19:33:40 UTC 2023 , Edited by admin on Sat Dec 16 19:33:40 UTC 2023

PRIMARY

Related Record Type Details


					X8HRQ6G9HF

GANGLIOSIDE M2

TARGET->CYTOTOXIC T-CELL

Amount:


					R4QQ5YK78D

C-C MOTIF CHEMOKINE 19

EXPRESSED PROTEIN->VECTOR

Amount:


					418XB47Y71

INTERLEUKIN-7 HUMAN RECOMBINANT

EXPRESSED PROTEIN->VECTOR

Amount:

Related Record Type Details


					22TCU7HE9E

Pomlucabtagene autoleucel

ACTIVE MOIETY

Comments:

cell-based gene therapy (antineoplastic)

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
CULTURE	EXPANSION	BIOLOGICAL	HUMAN INTERLEUKIN-2	FNO32LO217
LENTIVIRAL TRANSFECTION	TRANSFECTION	BIOLOGICAL	Pomlucabtagene autoleucel retroviral vector	6TE68QHJ9Q
CULTURE	ACTIVATOR	BIOLOGICAL	HUMAN INTERLEUKIN-2	FNO32LO217

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR					UNSPECIFIED SUBSTANCE	f7697a39 (not in database)
VECTOR EXPRESSED PROTEIN					Pomlucabtagene autoleucel CAR-T receptor	C2Z887B3BP

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
ENHANCED ACTIVATION	BIOLOGICAL		`P050J5FWC5` INTERFERON GAMMA