MIANSERIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H20N2
Molecular Weight	264.3648
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MIANSERIN

Structure Search

SMILES

CN1CCN2C(C1)C3=C(CC4=C2C=CC=C4)C=CC=C3

InChI

InChIKey=UEQUQVLFIPOEMF-UHFFFAOYSA-N

InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3

HIDE SMILES / InChI

Molecular Formula	C18H20N2
Molecular Weight	264.3648
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:16:58 UTC 2023` Edited by `admin` on `Fri Dec 15 15:16:58 UTC 2023`
Record UNII	250PJI13LM
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MIANSERIN

Official Name

English

DIBENZO(C,F)PYRAZINO(1,2-A)AZEPINE, 1,2,3,4,10,14B-HEXAHYDRO-2-METHYL-

Common Name

English

(±)-MIANSERIN

Common Name

English

MIANSERIN [MI]

Common Name

English

mianserin [INN]

Common Name

English

1,2,3,4,10,14B-HEXAHYDRO-2-METHYLDIBENZO(C,F)-PYRAZINO(1,2-A)AZEPINE

Common Name

English

Mianserin [WHO-DD]

Common Name

English

MIANSERIN [VANDF]

Common Name

English

J16.389I

Code

English

MIANSERIN [HSDB]

Common Name

English

TOLVON

Brand Name

English

MIANSERINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C72900

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

WHO-ATC

N06AX03

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

NCI_THESAURUS

C265

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

NCI_THESAURUS

C66885

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

WHO-VATC

QN06AX03

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

Code System Code Type Description

ChEMBL

CHEMBL6437

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

PRIMARY

SMS_ID

100000081183

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

PRIMARY

CHEBI

51137

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

PRIMARY

DRUG BANK

DB06148

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

PRIMARY

INN

2543

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

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LACTMED

Mianserin

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

PRIMARY

PUBCHEM

4184

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

PRIMARY

RXCUI

6929

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

PRIMARY

RxNorm

ECHA (EC/EINECS)

246-088-6

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

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DRUG CENTRAL

1796

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

PRIMARY

MERCK INDEX

m7521

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

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Merck Index

NCI_THESAURUS

C87209

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

PRIMARY

MESH

D008803

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

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WIKIPEDIA

MIANSERIN

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

PRIMARY

IUPHAR

135

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

PRIMARY

CAS

24219-97-4

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

PRIMARY

EVMPD

SUB08939MIG

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

PRIMARY

HSDB

7182

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

PRIMARY

FDA UNII

250PJI13LM

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

PRIMARY

EPA CompTox

DTXSID6023317

Created by admin on Fri Dec 15 15:16:58 UTC 2023 , Edited by admin on Fri Dec 15 15:16:58 UTC 2023

PRIMARY

Related Record Type Details


					83SJB1688K

MIANSERIN, (R)-

ENANTIOMER -> RACEMATE


					50U1BO5G5P

ALPHA-2A ADRENERGIC RECEPTOR

TARGET -> AGONIST

Interaction Type:

SHORT-ACTING


					A1AD8U189I

MIANSERIN, (S)-

ENANTIOMER -> RACEMATE


					8E4LAA4357

CYTOCHROME P450 2D6

METABOLIC ENZYME -> SUBSTRATE

Comments:

Metabolizing reaction by CYP2D6: O-demethylation


					2X03TN217S

MIANSERIN HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					8E4LAA4357

CYTOCHROME P450 2D6

METABOLIC ENZYME -> SUBSTRATE

Comments:

Pharmacological action: Tricyclic antidepressant drug (TCA)

Related Record Type Details


					WWZ32657N1

MIANSERIN 2-OXIDE

METABOLITE -> PARENT


					PI2H4ADR4C

DESMETHYLMIANSERIN

METABOLITE ACTIVE -> PARENT

Comments:

The plasma concentration of the compound was within the predicted therapeutic range in only 43% of patients.

Interaction Type:

AMOUNT ADMINISTERED

Qualification:

PLASMA

Amount:


					CD0R9QB6HD

8-HYDROXYMIANSERIN

METABOLITE -> PARENT

Related Record Type Details


					250PJI13LM

MIANSERIN

ACTIVE MOIETY