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Details

Stereochemistry ACHIRAL
Molecular Formula C16H13ClN2O2
Molecular Weight 300.74
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLOBAZAM

SMILES

CN1C2=C(C=C(Cl)C=C2)N(C3=CC=CC=C3)C(=O)CC1=O

InChI

InChIKey=CXOXHMZGEKVPMT-UHFFFAOYSA-N
InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3

HIDE SMILES / InChI
Molecular Formula C16H13ClN2O2
Molecular Weight 300.74
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:11:45 UTC 2023
Edited
by admin
on Fri Dec 15 15:11:45 UTC 2023
Record UNII
2MRO291B4U
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CLOBAZAM
DASH   EP   INN   JAN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
CLOBAZAM [MI]
Common Name English
CLOBAZAM [JAN]
Common Name English
URBADAN
Brand Name English
1H-1,5-BENZODIAZEPINE-2,4(3H,5H)-DIONE, 7-CHLORO-1-METHYL-5-PHENYL-
Systematic Name English
CLOBAZAM [ORANGE BOOK]
Common Name English
CLOBAZAM [VANDF]
Common Name English
FRISIUM
Brand Name English
URBANYL
Brand Name English
ONFI
Brand Name English
LM 2717
Code English
LM-2717
Code English
COLBAZAM [VANDF]
Common Name English
NSC-336279
Code English
HR-376
Code English
MYSTAN
Brand Name English
H 4723
Code English
HR 376
Code English
CLOBAZAM [EP MONOGRAPH]
Common Name English
CLOBAZAM [MART.]
Common Name English
7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione
Common Name English
SYMPAZAN
Brand Name English
H-4723
Code English
clobazam [INN]
Common Name English
CLOBAZAM [USAN]
Common Name English
Clobazam [WHO-DD]
Common Name English
Classification Tree Code System Code
DEA NO. 2751
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
FDA ORPHAN DRUG 248307
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
LIVERTOX NBK548865
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
WHO-ATC N05BA09
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
NCI_THESAURUS C28197
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
WHO-VATC QN05BA09
Created by admin on Fri Dec 15 15:11:46 UTC 2023 , Edited by admin on Fri Dec 15 15:11:46 UTC 2023
NDF-RT N0000175694
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
Code System Code Type Description
CAS
22316-47-8
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
PRIMARY
CHEBI
31413
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
PRIMARY
WIKIPEDIA
CLOBAZAM
Created by admin on Fri Dec 15 15:11:46 UTC 2023 , Edited by admin on Fri Dec 15 15:11:46 UTC 2023
PRIMARY
MESH
C012255
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
PRIMARY
EPA CompTox
DTXSID2046759
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
PRIMARY
PUBCHEM
2789
Created by admin on Fri Dec 15 15:11:46 UTC 2023 , Edited by admin on Fri Dec 15 15:11:46 UTC 2023
PRIMARY
NSC
336279
Created by admin on Fri Dec 15 15:11:46 UTC 2023 , Edited by admin on Fri Dec 15 15:11:46 UTC 2023
PRIMARY
INN
3055
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
PRIMARY
DAILYMED
2MRO291B4U
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
PRIMARY
DRUG BANK
DB00349
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
PRIMARY
EVMPD
SUB06673MIG
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
PRIMARY
SMS_ID
100000084299
Created by admin on Fri Dec 15 15:11:46 UTC 2023 , Edited by admin on Fri Dec 15 15:11:46 UTC 2023
PRIMARY
ChEMBL
CHEMBL70418
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
PRIMARY
HSDB
8343
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
PRIMARY
FDA UNII
2MRO291B4U
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
PRIMARY
NCI_THESAURUS
C81615
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
PRIMARY
ECHA (EC/EINECS)
244-908-7
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
PRIMARY
LACTMED
Clobazam
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
PRIMARY
RXCUI
21241
Created by admin on Fri Dec 15 15:11:46 UTC 2023 , Edited by admin on Fri Dec 15 15:11:46 UTC 2023
PRIMARY RxNorm
MERCK INDEX
m3626
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
PRIMARY Merck Index
NDF-RT
N0000182137
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
PRIMARY Cytochrome P450 2D6 Inhibitors [MoA]
IUPHAR
7149
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
PRIMARY
DRUG CENTRAL
682
Created by admin on Fri Dec 15 15:11:45 UTC 2023 , Edited by admin on Fri Dec 15 15:11:45 UTC 2023
PRIMARY
Related Record Type Details
CYTOCHROME P450 3A4
METABOLIC ENZYME -> INDUCER
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
Structure of CLOBAZAM
EXCRETED UNCHANGED
FECAL
Structure of CLOBAZAM
EXCRETED UNCHANGED
Clobazam is cleared mainly by metabolism with subsequent renal elimination of metabolites. In a mass balance study, 82% of the dose administered was recovered in the urine and 11% in the feces. Clobazam represents ~2 % of the dose recovered in urine.
URINE
CYTOCHROME P450 2C19
METABOLIC ENZYME -> SUBSTRATE
MULTIDRUG RESISTANCE PROTEIN 1
TRANSPORTER -> SUBSTRATE
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
MAJOR
CYTOCHROME P450 2B6
METABOLIC ENZYME -> SUBSTRATE
MINOR
Related Record Type Details
Structure of 9-HYDROXY-N-DESMETHYLCLOBAZAM
METABOLITE -> PARENT
Structure of N-DEMETHYLCLOBAZAM-3',4'-DIHYDRODIOL
METABOLITE -> PARENT
Structure of N-Desmethylclobazam
METABOLITE ACTIVE -> PARENT
Structure of 4'-HYDROXY-N-DESMETHYLCLOBAZAM
METABOLITE -> PARENT
Structure of 4'-HYDROXYCLOBAZAM
METABOLITE -> PARENT
Structure of 7-CHLORO-5-((3S,4S)-3,4-DIHYDROXYCYCLOHEXA-1,5-DIEN-1-YL)-1-METHYL-1,5-BENZODIAZEPINE-2,4-DIONE
METABOLITE -> PARENT
Related Record Type Details
Structure of 7-chloro-1,3,3-trimethyl-5-phenyl-1,5-dihydro-3H-1,5-benzodiazepine-2,4-dione
IMPURITY -> PARENT
Structure of N-[4-Chloro-2-(phenylamino)phenyl]-N-methylacetamide
IMPURITY -> PARENT
Structure of N-Desmethylclobazam
IMPURITY -> PARENT
Structure of 3-METHYLCLOBAZAM
IMPURITY -> PARENT
Structure of Methyl 3-((4-chloro-2-(phenylamino)phenyl)(methyl)amino)-3-oxopropanoate
IMPURITY -> PARENT
Structure of Deschloroclobazam
IMPURITY -> PARENT
Structure of 5-Chloro-1,2-dimethyl-3-phenyl-1H-benzimidazolium
IMPURITY -> PARENT
Related Record Type Details
Structure of CLOBAZAM
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC
Tmax PHARMACOKINETIC SINGLE- OR MULTIPLE-DOSE ADMINISTRATIONS

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