HYDROXYZINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H27ClN2O2
Molecular Weight	374.904
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of HYDROXYZINE

Structure Search

SMILES

OCCOCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3

InChI

InChIKey=ZQDWXGKKHFNSQK-UHFFFAOYSA-N

InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2

HIDE SMILES / InChI

Molecular Formula	C21H27ClN2O2
Molecular Weight	374.904
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:13:12 UTC 2023` Edited by `admin` on `Fri Dec 15 17:13:12 UTC 2023`
Record UNII	30S50YM8OG
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

HYDROXYZINE

Official Name

English

(±)-2-(2-(4-(P-CHLORO-.ALPHA.-PHENYLBENZYL)-1-PIPERAZINYL)ETHOXY)ETHANOL

Common Name

English

MAREX

Brand Name

English

U.C.B-4492

Brand Name

English

HYDROXYZINE [MI]

Common Name

English

ETHANOL, 2-(2-(4-(4-CHLORO-.ALPHA.-PHENYLBENZYL)-1-PIPERAZINYL)ETHOXY)-

Systematic Name

English

(±)-HYDROXYZINE

Common Name

English

HYDROXYZINE [MART.]

Common Name

English

HYDROXYZINE [VANDF]

Common Name

English

ETHANOL, 2-(2-(4-((4-CHLOROPHENYL)PHENYLMETHYL)-1-PIPERAZINYL)ETHOXY)-

Systematic Name

English

2-(2-(4-(P-CHLORO-.ALPHA.-PHENYLBENZYL)-1-PIPERAZINYL)ETHOXY)ETHANOL

Common Name

English

HYDROXYZINE [HSDB]

Common Name

English

ETHANOL, 2-(2-(4-((4-CHLOROPHENYL)PHENYLMETHYL)-1-PIPERAZINYL)ETHOXY)-,(±)-

Common Name

English

TRANQUIZINE

Brand Name

English

Hydroxyzine [WHO-DD]

Common Name

English

1-(P-CHLORO-.ALPHA.-PHENYLBENZYL)-4-(2-((2-HYDROXYETHOXY)ETHYL))PIPERAZINE

Common Name

English

1-(P-CHLOROBENZHYDRYL)-4-(2-(2-HYDROXYETHOXY)ETHYL)DIETHYLENEDIAMINE

Common Name

English

ATARAXOID

Brand Name

English

2-(2-(4-((4-CHLOROPHENYL)PHENYLMETHYL)-1-PIPERAZINYL)ETHOXY)ETHANOL

Systematic Name

English

NSC-169188

Code

English

hydroxyzine [INN]

Common Name

English

TRAN-Q

Brand Name

English

Classification Tree Code System Code

LIVERTOX

NBK548128

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

NDF-RT

N0000175750

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

NDF-RT

N0000000207

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

WHO-VATC

QN05BB01

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

NCI_THESAURUS

C29578

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

WHO-ATC

N05BB01

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

WHO-VATC

QN05BB51

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

WHO-ATC

N05BB51

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

Code System Code Type Description

NSC

169188

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

LACTMED

Hydroxyzine

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

PUBCHEM

3658

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

NCI_THESAURUS

C29103

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

RXCUI

5553

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

RxNorm

FDA UNII

30S50YM8OG

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

HSDB

3098

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

EPA CompTox

DTXSID8023137

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

SMS_ID

100000083664

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

CAS

147152-21-4

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

SUPERSEDED

MERCK INDEX

m6159

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

Merck Index

INN

599

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

WIKIPEDIA

HYDROXYZINE

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

ECHA (EC/EINECS)

200-693-1

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

IUPHAR

7199

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

CHEBI

5818

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

MESH

D006919

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

DRUG CENTRAL

1400

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

DAILYMED

30S50YM8OG

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

DRUG BANK

DB00557

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

ChEMBL

CHEMBL896

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

EVMPD

SUB08088MIG

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

CAS

68-88-2

Created by admin on Fri Dec 15 17:13:12 UTC 2023 , Edited by admin on Fri Dec 15 17:13:12 UTC 2023

PRIMARY

Related Record Type Details


					76755771U3

HYDROXYZINE DIHYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Amount:


					M20215MUFR

HYDROXYZINE PAMOATE

SALT/SOLVATE -> PARENT

Amount:


					CA67JF5Q4W

HYDROXYZINE MONOHYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Amount:


					28XBT591QG

HISTAMINE H1 RECEPTOR

TARGET -> INHIBITOR

Amount:


					8E4LAA4357

CYTOCHROME P450 2D6

METABOLIC ENZYME -> INHIBITOR

Comments:

Inhibition of bufuralol 1′-hydroxylation. Could be clinically relevant concentration in liver is within these values.

Interaction Type:

COMPETITIVE INHIBITOR

Qualification:

Ki

Amount:


					SEV29N8JND

POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 2

OFF-TARGET->INHIBITOR

Qualification:

IC50

Amount:

Related Record Type Details


					YO7261ME24

METABOLITE ACTIVE -> PARENT

Amount:


					V5V8VYQ65X

4-CHLOROBENZHYDROL

METABOLITE INACTIVE -> PARENT

Amount:

Related Record Type Details


					30S50YM8OG

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

PLASMA CONCENTRATION	PHARMACOKINETIC
LIVER/PLASMA RATIO	PHARMACOKINETIC

LIVER CONCENTRATION	PHARMACOKINETIC