PENCICLOVIR

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H15N5O3
Molecular Weight	253.2578
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PENCICLOVIR

Structure Search

SMILES

NC1=NC2=C(N=CN2CCC(CO)CO)C(=O)N1

InChI

InChIKey=JNTOCHDNEULJHD-UHFFFAOYSA-N

InChI=1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18)

HIDE SMILES / InChI

Molecular Formula	C10H15N5O3
Molecular Weight	253.2578
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:44:24 UTC 2023` Edited by `admin` on `Fri Dec 15 15:44:24 UTC 2023`
Record UNII	359HUE8FJC
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PENCICLOVIR

Official Name

English

PENCICLOVIR [USP IMPURITY]

Common Name

English

DENAVIR

Brand Name

English

BRL-39123

Code

English

NSC-759624

Code

English

PENCICLOVIR [VANDF]

Common Name

English

PENCICLOVIR [USAN]

Common Name

English

9-[4-Hydroxy-3-(hydroxymethyl)butyl]guanine

Systematic Name

English

PENCICLOVIR [MART.]

Common Name

English

2-AMINO-1,9-DIHYDRO-9-(4-HYDROXY-3-(HYDROXYMETHYL)BUTYL)-6H-PURIN-6-ONE

Systematic Name

English

Penciclovir [WHO-DD]

Common Name

English

penciclovir [INN]

Common Name

English

PENCICLOVIR [ORANGE BOOK]

Common Name

English

PENCICLOVIR [MI]

Common Name

English

Classification Tree Code System Code

WHO-ATC

J05AB13

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

NDF-RT

N0000175468

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

NDF-RT

N0000175459

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

WHO-VATC

QD06BB06

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

NDF-RT

N0000020060

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

NCI_THESAURUS

C29575

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

NDF-RT

N0000175459

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

WHO-VATC

QJ05AB13

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

WHO-ATC

D06BB06

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

NCI_THESAURUS

C281

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

NDF-RT

N0000175459

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

NCI_THESAURUS

C1556

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

Code System Code Type Description

DRUG CENTRAL

2079

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

WIKIPEDIA

PENCICLOVIR

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

EVMPD

SUB09661MIG

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

DRUG BANK

DB00299

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

NCI_THESAURUS

C66337

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

RXCUI

59839

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

RxNorm

NSC

759624

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

INN

6437

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

CHEBI

7956

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

SMS_ID

100000091073

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

ChEMBL

CHEMBL1540

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

HSDB

8123

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

USAN

EE-83

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

MERCK INDEX

m8462

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

Merck Index

FDA UNII

359HUE8FJC

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

LACTMED

Penciclovir

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

CAS

39809-25-1

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

DAILYMED

359HUE8FJC

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

EPA CompTox

DTXSID9046491

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

MESH

C053539

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

PUBCHEM

135398748

Created by admin on Fri Dec 15 15:44:24 UTC 2023 , Edited by admin on Fri Dec 15 15:44:24 UTC 2023

PRIMARY

Related Record Type Details


					9885M7D6JP

HUMAN HERPESVIRUS 3

TARGET ORGANISM->INHIBITOR

Comments:

The in vitro activities of penciclovir against HSV-1, HSV-2 and VZV are similar to those of aciclovir, with median IC50 values of 0.4, 1.5 and 4.0 µg/mL, respectively, in MRC-5 cells.

Qualification:

IC50

Amount:


					22G38P19RL

HUMAN HERPESVIRUS 1

TARGET ORGANISM->INHIBITOR

Comments:

The in vitro activities of penciclovir against HSV-1, HSV-2 and VZV are similar to those of aciclovir, with median IC50 values of 0.4, 1.5 and 4.0 µg/mL, respectively, in MRC-5 cells.

Qualification:

IC50

Amount:


					74J6DNH49U

HUMAN HERPESVIRUS 2

TARGET ORGANISM->INHIBITOR

Comments:

The in vitro activities of penciclovir against HSV-1, HSV-2 and VZV are similar to those of aciclovir, with median IC50 values of 0.4, 1.5 and 4.0 µg/mL, respectively, in MRC-5 cells.

Qualification:

IC50

Amount:


					P06226385L

PENCICLOVIR SODIUM

SALT/SOLVATE -> PARENT

Amount:


					5840721PJZ

OAT-2

TRANSPORTER -> SUBSTRATE

Amount:

Related Record Type Details


					QIC03ANI02

PRODRUG -> METABOLITE ACTIVE

Amount:


					N8C09G1O3O

6-DEOXYPENCICLOVIR

METABOLITE INACTIVE -> PARENT

Amount:

Related Record Type Details


					QIC03ANI02

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

Related Record Type Details


					359HUE8FJC

ACTIVE MOIETY

Amount: