MEFENAMIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H15NO2
Molecular Weight	241.2851
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CC1=CC=CC(NC2=CC=CC=C2C(O)=O)=C1C

InChI

InChIKey=HYYBABOKPJLUIN-UHFFFAOYSA-N

InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)

HIDE SMILES / InChI

Molecular Formula	C15H15NO2
Molecular Weight	241.2851
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical
Record UNII	367589PJ2C
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

MEFENAMIC ACID

Official Name

English

GARDAN

Brand Name

English

M01AG01

Code

English

PONSTEL

Brand Name

English

N-2,3-Xylylanthranilic acid

Systematic Name

English

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Classification Tree

Code System

Code

Enzyme Inhibitors

NDF-RT

N0000000160

Established Pharmacologic Class

NDF-RT

N0000175722

Fenamates

WHO-ATC

M01AG01

Analgesic and Antipyretic

NCI_THESAURUS

C257

Chemical Classes for Pharmacologic Classification

NDF-RT

N0000175721

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Code System

Code

Type

Description

MESH

D008528

PRIMARY

CAS

61-68-7

PRIMARY

ChEMBL

CHEMBL686

PRIMARY

DAILYMED

367589PJ2C

PRIMARY

ECHA (EC/EINECS)

200-513-1

PRIMARY

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					ZWJ2Y6JZWY

OAT-3

TRANSPORTER -> INHIBITOR


					4HZ67LW8L7

OAT-4

TRANSPORTER -> INHIBITOR


					I81U7H57XI

OAT-1

TRANSPORTER -> INHIBITOR


					0M77ZW789J

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B7

METABOLIC ENZYME -> INHIBITOR

Comments:

inhibits pradigastat glucuronidation

Amount:

RELATIONSHIP_AMOUNT 1.2 MICROMOLAR (average)


					5840721PJZ

OAT-2

TRANSPORTER -> INHIBITOR

Amount:

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3-CARBOXY MEFENAMIC ACID ACYL-.BETA.-D-GLUCURONIDE

METABOLITE -> PARENT

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					OX5H10G1RG

MEFENAMIC ACID GLUCURONIDE

METABOLITE -> PARENT

Interaction Type:

MAJOR


					53XT40J50Q

3-HYDROXYMETHYL MEFENAMIC ACID ACYL-.BETA.-D-GLUCURONIDE

METABOLITE -> PARENT

Interaction Type:

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					LLA90H5KPK

3-CARBOXYMEFENAMIC ACID

METABOLITE -> PARENT


					8L4T2779IX

3-HYDROXYMETHYL MEFENAMIC ACID

METABOLITE -> PARENT

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Benzoic acid

IMPURITY -> PARENT

Comments:

Correction factors: for the calculation of contents, multiply the peak areas by 4.0

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

[<0.1] PERCENT PEAK AREA (limits)


					8P0867193V

O-CHLOROBENZOIC ACID

IMPURITY -> PARENT

Comments:

Correction factors: for the calculation of contents, multiply the peak areas by 5.9

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

[<0.1] PERCENT PEAK AREA (limits)


					ZD450ABI9X

2,3-XYLIDINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

[<100] PPM (limits)


					U88XP2706B

2,3-DIMETHYL-N-PHENYLANILINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

[<0.1] PERCENT PEAK AREA (limits)


					3A84PG9047

N-(2,3-DIMETHYLPHENYL)-2-((2,3-DIMETHYLPHENYL)AMINO)BENZAMIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

[<0.1] PERCENT PEAK AREA (limits)

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					367589PJ2C

MEFENAMIC ACID

ACTIVE MOIETY

Amount:

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