U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C59H84N16O12.C2H4O2
Molecular Weight 1269.4502
Optical Activity UNSPECIFIED
Defined Stereocenters 9 / 9
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LEUPROLIDE ACETATE

SMILES

CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=C3C=CC=C4)NC(=O)[C@H](CC5=CNC=N5)NC(=O)[C@@H]6CCC(=O)N6

InChI

InChIKey=RGLRXNKKBLIBQS-XNHQSDQCSA-N
InChI=1S/C59H84N16O12.C2H4O2/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40;1-2(3)4/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64);1H3,(H,3,4)/t40-,41-,42-,43+,44-,45-,46-,47-,48-;/m0./s1

HIDE SMILES / InChI
Molecular Formula C2H4O2
Molecular Weight 60.052
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C59H84N16O12
Molecular Weight 1209.3983
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 9 / 9
E/Z Centers 3
Optical Activity UNSPECIFIED

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Sat Dec 16 05:01:05 UTC 2023
Edited
by admin
on Sat Dec 16 05:01:05 UTC 2023
Record UNII
37JNS02E7V
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LEUPROLIDE ACETATE
ORANGE BOOK   USAN   USP   USP-RS   VANDF  
USAN  
Official Name English
5-OXO-L-PROLYL-L-HISTIDYL-L-TRYPTOPHYL-L-SERYL-L-TRYOSYL-D-LEUCYL-L-LEUCYL-L-ARGINYL-N-ETHYL-L-PROLINAMIDE ACETATE (SALT)
Systematic Name English
LUCRIN
Brand Name English
LEUPROLIDE MONOACETATE [MI]
Common Name English
LEUPROLIDE ACETATE [ORANGE BOOK]
Common Name English
TAP-144
Code English
TAP-144-SR
Common Name English
PGLU-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHC2H5 ACETATE SALT
Systematic Name English
LEUPORELIN ACETATE
Common Name English
LEUPROLIDE ACETATE [VANDF]
Common Name English
LEUPRORELIN ACETATE
MART.   WHO-DD  
Common Name English
ABBOTT-43818
Code English
1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-D-LEUCINE-9-(N-ETHYL-L-PROLINAMIDE)-, ACETATE (1:1)
Systematic Name English
LEUPROLIDE ACETATE [USAN]
Common Name English
A-43818
Code English
LUPRON DEPOT
Brand Name English
LUPANETA
Common Name English
CARCINIL
Brand Name English
LUPRON
Brand Name English
Leuprorelin acetate [WHO-DD]
Common Name English
VIADUR
Brand Name English
TRENANTONE
Brand Name English
LEUPRORELIN ACETATE [JAN]
Common Name English
LUTRATE DEPOT
Brand Name English
LEUPROLIDE ACETATE [USP-RS]
Common Name English
LEUPLIN
Brand Name English
PROSTAP
Brand Name English
LEUPROLIDE MONOACETATE
MI  
Common Name English
LEUPROLIDE ACETATE [USP MONOGRAPH]
Common Name English
ELIGARD
Brand Name English
LEUPRORELIN ACETATE [MART.]
Common Name English
FENSOLVI
Brand Name English
LUTEINIZING HORMONE-RELEASING FACTOR, 6-D-LEUCINE-9-(N-ETHYL-L-PROLINAMIDE)-10-DEGLYCINAMIDE ACETATE (SALT)
Systematic Name English
ENANTONE
Brand Name English
Classification Tree Code System Code
EU-Orphan Drug EU/3/16/1821
Created by admin on Sat Dec 16 05:01:05 UTC 2023 , Edited by admin on Sat Dec 16 05:01:05 UTC 2023
FDA ORPHAN DRUG 28688
Created by admin on Sat Dec 16 05:01:05 UTC 2023 , Edited by admin on Sat Dec 16 05:01:05 UTC 2023
NCI_THESAURUS C1910
Created by admin on Sat Dec 16 05:01:05 UTC 2023 , Edited by admin on Sat Dec 16 05:01:05 UTC 2023
Code System Code Type Description
RXCUI
203217
Created by admin on Sat Dec 16 05:01:05 UTC 2023 , Edited by admin on Sat Dec 16 05:01:05 UTC 2023
PRIMARY RxNorm
ChEMBL
CHEMBL1201199
Created by admin on Sat Dec 16 05:01:05 UTC 2023 , Edited by admin on Sat Dec 16 05:01:05 UTC 2023
PRIMARY
FDA UNII
37JNS02E7V
Created by admin on Sat Dec 16 05:01:05 UTC 2023 , Edited by admin on Sat Dec 16 05:01:05 UTC 2023
PRIMARY
EVMPD
SUB02900MIG
Created by admin on Sat Dec 16 05:01:05 UTC 2023 , Edited by admin on Sat Dec 16 05:01:05 UTC 2023
PRIMARY
DRUG BANK
DBSALT000105
Created by admin on Sat Dec 16 05:01:05 UTC 2023 , Edited by admin on Sat Dec 16 05:01:05 UTC 2023
PRIMARY
MERCK INDEX
m6779
Created by admin on Sat Dec 16 05:01:05 UTC 2023 , Edited by admin on Sat Dec 16 05:01:05 UTC 2023
PRIMARY Merck Index
NCI_THESAURUS
C1319
Created by admin on Sat Dec 16 05:01:05 UTC 2023 , Edited by admin on Sat Dec 16 05:01:05 UTC 2023
PRIMARY
SMS_ID
100000091573
Created by admin on Sat Dec 16 05:01:05 UTC 2023 , Edited by admin on Sat Dec 16 05:01:05 UTC 2023
PRIMARY
CAS
88793-81-1
Created by admin on Sat Dec 16 05:01:05 UTC 2023 , Edited by admin on Sat Dec 16 05:01:05 UTC 2023
NON-SPECIFIC STOICHIOMETRY
EPA CompTox
DTXSID7049009
Created by admin on Sat Dec 16 05:01:05 UTC 2023 , Edited by admin on Sat Dec 16 05:01:05 UTC 2023
PRIMARY
DAILYMED
37JNS02E7V
Created by admin on Sat Dec 16 05:01:05 UTC 2023 , Edited by admin on Sat Dec 16 05:01:05 UTC 2023
PRIMARY
PUBCHEM
657180
Created by admin on Sat Dec 16 05:01:05 UTC 2023 , Edited by admin on Sat Dec 16 05:01:05 UTC 2023
PRIMARY
CHEBI
63597
Created by admin on Sat Dec 16 05:01:05 UTC 2023 , Edited by admin on Sat Dec 16 05:01:05 UTC 2023
PRIMARY
CAS
74381-53-6
Created by admin on Sat Dec 16 05:01:05 UTC 2023 , Edited by admin on Sat Dec 16 05:01:05 UTC 2023
PRIMARY
RS_ITEM_NUM
1358503
Created by admin on Sat Dec 16 05:01:05 UTC 2023 , Edited by admin on Sat Dec 16 05:01:05 UTC 2023
PRIMARY
Related Record Type Details
Structure of LEUPROLIDE
PARENT -> SALT/SOLVATE
GONADORELIN
TARGET -> AGONIST
Related Record Type Details
Structure of (O-ACETYL-L-SER)-LEUPROLIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of D-HIS-LEUPROLIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of L-LEU6-LEUPROLIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of D-SER-LEUPROLIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Related Record Type Details
Structure of LEUPROLIDE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
NOAEL PHARMACOKINETIC
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966