SUTEZOLID

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H20FN3O3S
Molecular Weight	353.412
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of SUTEZOLID

Structure Search

SMILES

CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(F)=C(C=C2)N3CCSCC3

InChI

InChIKey=FNDDDNOJWPQCBZ-ZDUSSCGKSA-N

InChI=1S/C16H20FN3O3S/c1-11(21)18-9-13-10-20(16(22)23-13)12-2-3-15(14(17)8-12)19-4-6-24-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C16H20FN3O3S
Molecular Weight	353.412
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:47:55 UTC 2023` Edited by `admin` on `Fri Dec 15 19:47:55 UTC 2023`
Record UNII	3A71182L8P
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SUTEZOLID

Official Name

English

U-100480

Code

English

Sutezolid [WHO-DD]

Common Name

English

ACETAMIDE, N-((3-(3-FLUORO-4-(4-THIOMORPHOLINYL)PHENYL)-2-OXO-5-OXAZOLIDINYL)METHYL)-, (S)-

Common Name

English

PNU-100480

Code

English

SUTEZOLID [USAN]

Common Name

English

(S)-N-((3-(3-FLUORO-4-THIOMORPHOLINOPHENYL)-2-OXOOXAZOLIDIN-5-YL)METHYL)ACETAMIDE

Systematic Name

English

N-({(5S)-3-[3-Fluoro-4-(thiomorpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl}methyl) acetamide

Systematic Name

English

sutezolid [INN]

Common Name

English

U-480

Code

English

U100480

Code

English

OXAZOLIDININONE

Common Name

English

NSC-742407

Code

English

ACETAMIDE, N-(((5S)-3-(3-FLUORO-4-(4-THIOMORPHOLINYL)PHENYL)-2-OXO-5-OXAZOLIDINYL) METHYL)-

Common Name

English

Classification Tree Code System Code

EU-Orphan Drug

EU/3/11/897

Created by admin on Fri Dec 15 19:47:55 UTC 2023 , Edited by admin on Fri Dec 15 19:47:55 UTC 2023

FDA ORPHAN DRUG

328210

Created by admin on Fri Dec 15 19:47:55 UTC 2023 , Edited by admin on Fri Dec 15 19:47:55 UTC 2023

NCI_THESAURUS

C280

Created by admin on Fri Dec 15 19:47:55 UTC 2023 , Edited by admin on Fri Dec 15 19:47:55 UTC 2023

Code System Code Type Description

EPA CompTox

DTXSID20168611

Created by admin on Fri Dec 15 19:47:55 UTC 2023 , Edited by admin on Fri Dec 15 19:47:55 UTC 2023

PRIMARY

NSC

742407

Created by admin on Fri Dec 15 19:47:55 UTC 2023 , Edited by admin on Fri Dec 15 19:47:55 UTC 2023

PRIMARY

NCI_THESAURUS

C152482

Created by admin on Fri Dec 15 19:47:55 UTC 2023 , Edited by admin on Fri Dec 15 19:47:55 UTC 2023

PRIMARY

ChEMBL

CHEMBL288149

Created by admin on Fri Dec 15 19:47:55 UTC 2023 , Edited by admin on Fri Dec 15 19:47:55 UTC 2023

PRIMARY

DRUG BANK

DB11905

Created by admin on Fri Dec 15 19:47:55 UTC 2023 , Edited by admin on Fri Dec 15 19:47:55 UTC 2023

PRIMARY

PUBCHEM

465951

Created by admin on Fri Dec 15 19:47:55 UTC 2023 , Edited by admin on Fri Dec 15 19:47:55 UTC 2023

PRIMARY

SMS_ID

100000182673

Created by admin on Fri Dec 15 19:47:55 UTC 2023 , Edited by admin on Fri Dec 15 19:47:55 UTC 2023

PRIMARY

USAN

XX-127

Created by admin on Fri Dec 15 19:47:55 UTC 2023 , Edited by admin on Fri Dec 15 19:47:55 UTC 2023

PRIMARY

CAS

168828-58-8

Created by admin on Fri Dec 15 19:47:55 UTC 2023 , Edited by admin on Fri Dec 15 19:47:55 UTC 2023

PRIMARY

WIKIPEDIA

SUTEZOLID

Created by admin on Fri Dec 15 19:47:55 UTC 2023 , Edited by admin on Fri Dec 15 19:47:55 UTC 2023

PRIMARY

Sutezolid (PNU-100480, PF-02341272) is an oxazolidinone antibiotic currently in development as a treatment for extensively drug-resistant tuberculosis.

INN

9444

Created by admin on Fri Dec 15 19:47:55 UTC 2023 , Edited by admin on Fri Dec 15 19:47:55 UTC 2023

PRIMARY

FDA UNII

3A71182L8P

Created by admin on Fri Dec 15 19:47:55 UTC 2023 , Edited by admin on Fri Dec 15 19:47:55 UTC 2023

PRIMARY

Related Record Type Details


					R0EM8D5HFD

MYCOBACTERIUM TUBERCULOSIS

TARGET ORGANISM->INHIBITOR

Comments:

Intracellular Mycobacteria

Qualification:

IC50

Amount:


					R0EM8D5HFD

MYCOBACTERIUM TUBERCULOSIS

TARGET ORGANISM->INHIBITOR

Qualification:

MIC

Amount:

Related Record Type Details


					C26337G9CY

Sutezolid sulfoxide

METABOLITE ACTIVE -> PARENT

Comments:

Metabolite 17 fold less potent in killing intracellular M. Tb.

Interaction Type:

MAJOR

Amount:

Related Record Type Details


					3A71182L8P

SUTEZOLID

ACTIVE MOIETY

Comments:

Originator: Pharmacia Corporation; Developer: Sequella; Class: Acetamide, Amide, Antibacterial, Oxazolidinone, Small molecule, Thiamorpholine; Mechanism of Action: Protein 30S ribosomal subunit inhibitor; Highest Development Phase: No development reported for Tuberculosis; Most Recent Events: 27 Jul 2015 No recent reports on development identified - Phase-II for Tuberculosis (Treatment-naive) in South Africa (PO): 27 Jul 2015 No recent reports on development identified - Phase-I for Tuberculosis (In volunteers) in USA (PO): 09 Aug 2013 Pfizer terminates its involvement in the development of sutezolid

Amount: