ALPHA-1A ADRENERGIC RECEPTOR

Approval Year

Substance Class	Protein
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	3T7136LE8K
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

ALPHA-1A ADRENERGIC RECEPTOR

Common Name

English

Adrenergic α1A receptor

Common Name

English

ADRA1C

Common Name

English

ALPHA-1A ADRENOCEPTOR

Common Name

English

Adrenergic α1A

Common Name

English

Showing 1 to 5 of 7 entries

Previous1 2Next

Show entries

Code System

Code

Type

Description

FDA UNII

3T7136LE8K

PRIMARY

PHAROS

P35348

PRIMARY

UNIPROT

P35348

PRIMARY

WIKIPEDIA

ALPHA-1_ADRENERGIC_RECEPTOR

PRIMARY

Showing 1 to 4 of 4 entries

Previous1Next

Subunit 0

Show entries

From	To
1_99	1_176

Showing 1 to 1 of 1 entries

Previous1Next

Glycosylation Type

HUMAN

Show entries

Glycosylation Link Type	Site
N	1_7
N	1_13
N	1_22

Showing 1 to 3 of 3 entries

Previous1Next

Show entries

Related Record

Type

Details


					R5H8897N95

LABETALOL

AGONIST -> TARGET


					R9PHW59SFN

NAFTOPIDIL

INHIBITOR -> TARGET

Qualification:

Ki

Amount:

70 NANOMOLAR (average)


					2L5SGH4CVS

RS-97078 FREE BASE

INHIBITOR -> TARGET


					0M3S43XK27

BENZPHETAMINE

AGONIST -> TARGET

Amount:


					CUZ39LUY82

SILODOSIN

INHIBITOR -> TARGET

Comments:

Selectivity of silodosin determined in cloned human α1-adrenergic receptor (α1-AR) subtypes in cultured Chinese hamster ovary cells.Silodosin has greater affinity for the α1A-adrenergic receptor than for the α1B-adrenergic receptor (by a factor of 583), minimizing the propensity for blood pressure-related adverse effects mediated by α1B blockade.

Qualification:

Ki

Amount:

0.036 NANOMOLAR [0.026 to 0.046] (average)

Showing 1 to 5 of 52 entries

Previous1 2 3 4 5…11Next

Show entries

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL	ESTIMATED C2340H3699N616O636PS28
MOL_WEIGHT	CHEMICAL

Showing 1 to 2 of 2 entries

Previous1Next