SILODOSIN

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H32F3N3O4
Molecular Weight	495.5345
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of SILODOSIN

Structure Search

SMILES

C[C@H](CC1=CC(C(N)=O)=C2N(CCCO)CCC2=C1)NCCOC3=CC=CC=C3OCC(F)(F)F

InChI

InChIKey=PNCPYILNMDWPEY-QGZVFWFLSA-N

InChI=1S/C25H32F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-6,14-15,17,30,32H,4,7-13,16H2,1H3,(H2,29,33)/t17-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C25H32F3N3O4
Molecular Weight	495.5345
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:49:12 UTC 2023` Edited by `admin` on `Fri Dec 15 15:49:12 UTC 2023`
Record UNII	CUZ39LUY82
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SILODOSIN

Official Name

English

RAPAFLO

Brand Name

English

SILODOSIN [ORANGE BOOK]

Common Name

English

KSO-0400

Common Name

English

URIEF

Brand Name

English

SILODOSIN [EMA EPAR]

Common Name

English

(-)-1-(3-HYDROXYPROPYL)-5-((2R)-2-((2-(2-(2,2,2-TRIFLUOROETHOXY)PHENOXY)ETHYL)AMINO)PROPYL)-2,3-DIHYDRO-1H-INDOLE-7-CARBOXAMIDE

Systematic Name

English

2,3-DIHYDRO-1-(3-HYDROXYPROPYL)-5-((2R)-2-((2-(2-(2,2,2-TRIFLUOROETHOXY)PHENOXY)ETHYL)AMINO)PROPYL)-1H-INDOLE-7-CARBOXAMIDE

Systematic Name

English

KAD-3213

Code

English

SILODOSIN [JAN]

Common Name

English

silodosin [INN]

Common Name

English

SILODOSIN [MI]

Common Name

English

SILODYX

Brand Name

English

RAPILIF

Brand Name

English

SILODOSIN [VANDF]

Common Name

English

Silodosin [WHO-DD]

Common Name

English

KMD-3213

Code

English

SILODAL

Brand Name

English

SILODOSIN [MART.]

Common Name

English

UROREC

Brand Name

English

Classification Tree Code System Code

EMA ASSESSMENT REPORTS

UROREC (AUTHORIZED: PROSTATIC HYPERPLASIA)

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

NDF-RT

N0000175553

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

WHO-ATC

G04CA04

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

LIVERTOX

NBK548170

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

NCI_THESAURUS

C29713

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

NDF-RT

N0000000099

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

EMA ASSESSMENT REPORTS

SILODYX (AUTHORIZED: PROSTATIC HYPERPLASIA)

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

WHO-VATC

QG04CA04

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

Code System Code Type Description

SMS_ID

100000090781

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

PRIMARY

EPA CompTox

DTXSID40167045

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

PRIMARY

DRUG CENTRAL

4151

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

PRIMARY

INN

8043

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

PRIMARY

DRUG BANK

DB06207

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

PRIMARY

CAS

160970-54-7

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

PRIMARY

DAILYMED

CUZ39LUY82

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

PRIMARY

RXCUI

720825

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

PRIMARY

RxNorm

MERCK INDEX

m9912

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

PRIMARY

Merck Index

WIKIPEDIA

SILODOSIN

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

PRIMARY

NCI_THESAURUS

C81372

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

PRIMARY

EVMPD

SUB23152

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

PRIMARY

FDA UNII

CUZ39LUY82

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

PRIMARY

ChEMBL

CHEMBL24778

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

PRIMARY

IUPHAR

493

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

PRIMARY

PUBCHEM

5312125

Created by admin on Fri Dec 15 15:49:12 UTC 2023 , Edited by admin on Fri Dec 15 15:49:12 UTC 2023

PRIMARY

Related Record Type Details


					3T7136LE8K

ALPHA-1A ADRENERGIC RECEPTOR

TARGET -> INHIBITOR

Comments:

Selectivity of silodosin determined in cloned human α1-adrenergic receptor (α1-AR) subtypes in cultured Chinese hamster ovary cells.Silodosin has greater affinity for the α1A-adrenergic receptor than for the α1B-adrenergic receptor (by a factor of 583), minimizing the propensity for blood pressure-related adverse effects mediated by α1B blockade.

Qualification:

Ki

Amount:


					CUZ39LUY82

SILODOSIN

CUMULATIVE EXCRETION

Qualification:

URINE

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					Q7A4S7HOP4

ALPHA-1B ADRENERGIC RECEPTOR

OFF-TARGET->INHIBITOR

Comments:

Selectivity of silodosin determined in cloned human α1-adrenergic receptor (α1-AR) subtypes in cultured Chinese hamster ovary cells.

Qualification:

Ki

Amount:


					CUZ39LUY82

SILODOSIN

CUMULATIVE EXCRETION

Qualification:

FECAL

Amount:


					P5O3A2DHB2

ALPHA-1D ADRENERGIC RECEPTOR

OFF-TARGET->INHIBITOR

Related Record Type Details


					TTL076P23E

KDM-3289

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

FECAL; PLASMA; URINE


					Q4ZA32SEES

KDM-3295

METABOLITE -> PARENT

Comments:

MEDIATOR-S9+NAD

Interaction Type:

MINOR

Qualification:

FECAL; PLASMA; URINE


					61Q978167Z

KMD-3213G

METABOLITE LESS ACTIVE -> PARENT

Comments:

Major in plasma

Interaction Type:

MAJOR

Qualification:

PLASMA; URINE


					0JY2OEQ57N

KMD-3241G

METABOLITE ACTIVE -> PRODRUG

Comments:

Mediator: UDP-glucuronosyltransferase

Interaction Type:

MAJOR

Qualification:

PLASMA; URINE


					M4QEF9744X

KMD-3293

METABOLITE LESS ACTIVE -> PARENT

Comments:

Major in plasma and urine; S9+NAD mediator; Does not significanly contribute to the efficacy

Interaction Type:

MAJOR

Qualification:

FECAL; PLASMA; URINE


					6787MV7QU0

KMD-3241

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

FECAL; PLASMA; URINE

Related Record Type Details


					CUZ39LUY82

SILODOSIN

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC