CLINDAMYCIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C18H33ClN2O5S
Molecular Weight	424.983
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CLINDAMYCIN

Structure Search

SMILES

[H][C@@]1(O[C@H](SC)[C@H](O)[C@@H](O)[C@H]1O)[C@H](NC(=O)[C@@H]2C[C@@H](CCC)CN2C)[C@H](C)Cl

InChI

InChIKey=KDLRVYVGXIQJDK-AWPVFWJPSA-N

InChI=1S/C18H33ClN2O5S/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25)/t9-,10+,11-,12+,13-,14+,15+,16+,18+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C18H33ClN2O5S
Molecular Weight	424.983
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	9 / 9
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 15:52:52 UTC 2023` Edited by `admin` on `Sat Dec 16 15:52:52 UTC 2023`
Record UNII	3U02EL437C
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CLINDAMYCIN

Official Name

English

U-21,251

Code

English

clindamycin [INN]

Common Name

English

U-21251

Code

English

CLINDAMYCIN [MART.]

Common Name

English

CLINDAMYCIN [USAN]

Common Name

English

CLINDAMYCIN [GREEN BOOK]

Common Name

English

Clindamycin [WHO-DD]

Common Name

English

METHYL 7-CHLORO-6,7,8-TRIDEOXY-6-(1-METHYL-TRANS-4-PROPYL-L-2-PYRROLIDINECARBOXAMIDO)-1-THIO-L-THREO-.ALPHA.-D-GALACTO-OCTOPYRANOSIDE

Common Name

English

7(S)-CHLORO-7-DEOXYLINCOMYCIN

Common Name

English

CLINDAMYCIN [VANDF]

Common Name

English

CLINDAMYCIN PHOSPHATE IMPURITY E [EP IMPURITY]

Common Name

English

CLINDAMYCIN [HSDB]

Common Name

English

L-THREO-.ALPHA.-D-GALACTO-OCTOPYRANOSIDE, METHYL 7-CHLORO-6,7,8-TRIDEOXY-6-(((1-METHYL-4-PROPYL-2-PYRROLIDINYL)CARBONYL)AMINO)-1-THIO-, (2S-TRANS)-

Common Name

English

CLINDAMYCIN [MI]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QD10AF01

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

CFR

21 CFR 520.447

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

WHO-ATC

J01FF01

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

WHO-VATC

QJ01FF01

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

NDF-RT

N0000175442

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

WHO-ATC

G01AA10

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

CFR

21 CFR 520.446

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

WHO-ATC

D10AF51

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

LIVERTOX

NBK548292

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

NDF-RT

N0000175442

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

NDF-RT

N0000175443

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

WHO-VATC

QG01AA10

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

WHO-ATC

D10AF01

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

FDA ORPHAN DRUG

26988

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

NDF-RT

N0000009982

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

6.2.2

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

NCI_THESAURUS

C82922

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

FDA ORPHAN DRUG

27088

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

WHO-VATC

QD10AF51

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

Code System Code Type Description

CHEBI

3745

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

LACTMED

Clindamycin

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

INN

2550

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

WIKIPEDIA

CLINDAMYCIN

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

MERCK INDEX

m3624

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

Merck Index

FDA UNII

3U02EL437C

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

EPA CompTox

DTXSID2022836

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

DRUG CENTRAL

678

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

CAS

18323-44-9

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

NCI_THESAURUS

C377

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

SMS_ID

100000084276

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

EVMPD

SUB06665MIG

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

ECHA (EC/EINECS)

242-209-1

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

MESH

D002981

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

DAILYMED

3U02EL437C

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

ChEMBL

CHEMBL1753

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

PUBCHEM

446598

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

RXCUI

2582

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

RxNorm

HSDB

3037

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

DRUG BANK

DB01190

Created by admin on Sat Dec 16 15:52:54 UTC 2023 , Edited by admin on Sat Dec 16 15:52:54 UTC 2023

PRIMARY

Related Record Type Details


					3U6TN9Y2LD

MYCOPLASMA FERMENTANS

TARGET ORGANISM->INHIBITOR

Comments:

18 STRAINS; MIC range listed

Qualification:

MIC90

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					805SU96HKF

CYTOCHROME P450 3A5

METABOLIC ENZYME -> SUBSTRATE


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> INHIBITOR


					T20OQ1YN1W

CLINDAMYCIN HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					ZNC153389R

CLINDAMYCIN HYDROCHLORIDE MONOHYDRATE

SALT/SOLVATE -> PARENT


					65P5WPF3BJ

METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS

TARGET ORGANISM->INHIBITOR

Amount:

Related Record Type Details


					AM87UQ20EB

CLINDAMYCIN SULFOXIDE

METABOLITE -> PARENT

Comments:

IN VITRO


					0C0YZC7W4S

N-DEMETHYLCLINDAMYCIN

PARENT -> METABOLITE

Comments:

IN VITRO

Related Record Type Details


					EH6D7113I8

CLINDAMYCIN PHOSPHATE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					EH6D7113I8

CLINDAMYCIN PHOSPHATE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

Related Record Type Details


					3U02EL437C

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Tmax	PHARMACOKINETIC				ROUTE OF ADMINSTRATION: IM

MIC	BIOLOGICAL				PATHOGEN: ANAEROBIC BACTERIA SUSCEPTIBILITY: INTERMEDIATE

ORAL BIOAVAILABILITY	PHARMACOKINETIC

Biological Half-life	BIOLOGICAL				POPULATION: ELDERLY

Biological Half-life	PHARMACOKINETIC				POPULATION: CHILDREN

MIC	BIOLOGICAL				SUSCEPTIBILITY: RESISTANT PATHOGEN: ANAEROBIC BACTERIA

MIC	BIOLOGICAL				PATHOGEN: STAPHYLOCOCCUS spp. SUSCEPTIBILITY: SUSCEPTIBLE

Tmax	PHARMACOKINETIC				ROUTE OF ADMINISTRATION: ORAL

MIC	BIOLOGICAL				PATHOGEN: STAPHYLOCOCCUS spp. SUSCEPTIBILITY: RESISTANT

MIC	BIOLOGICAL				PATHOGEN: STAPHYLOCOCCUS spp. SUSCEPTIBILITY: INTERMEDIATE

Biological Half-life	PHARMACOKINETIC				POPULATION: ADULTS

Biological Half-life	PHARMACOKINETIC				POPULATION: PREMATURE NEONATES

MIC	BIOLOGICAL				PATHOGEN: S. PNEUMONIAE AND OTHER STREPTOCOCCUS spp. SUSCEPTIBILITY: INTERMEDIATE

Biological Half-life	PHARMACOKINETIC				POPULATION: FULL-TERM NEONATES

MIC	BIOLOGICAL				SUSCEPTIBILITY: SUSCEPTIBLE PATHOGEN: S. PNEUMONIAE AND OTHER STREPTOCOCCUS spp.

Biological Half-life	PHARMACOKINETIC				POPULATION: INFANTS 1 MONTH TO 1 YEAR

MIC	BIOLOGICAL				PATHOGEN: S. PNEUMONIAE AND OTHER STREPTOCOCCUS spp. SUSCEPTIBILITY: RESISTANT

MIC	BIOLOGICAL				SUSCEPTIBILITY: SUSCEPTIBLE PATHOGEN: ANAEROBIC BACTERIA