U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
86413
Substance Class
Concept
Record UNII
3Y7ANB3DKG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GI-101
Code English
GI 101 [WHO-DD]
Common Name English
Bi-specific fragment crystallizable region (Fc) fusion protein containing cluster of differentiation 80 ectodomain as an N-terminal moiety and interleukin-2 variant as a C-terminal moiety conjugated with human immunoglobulin G4 Fc
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 905422
Created by admin on Sat Dec 16 19:11:14 UTC 2023 , Edited by admin on Sat Dec 16 19:11:14 UTC 2023
Code System Code Type Description
FDA UNII
3Y7ANB3DKG
Created by admin on Sat Dec 16 19:11:14 UTC 2023 , Edited by admin on Sat Dec 16 19:11:14 UTC 2023
PRIMARY
This is a non-substance concept
Related Record Type Details
CYTOTOXIC T-LYMPHOCYTE PROTEIN 4
TARGET -> INHIBITOR
IN-VIVO
T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28
TARGET -> ACTIVATOR
GI101 has high binding affinity to CTLA4 acting as a decoy ligand, thereby enhancing the interaction between endogenous CD80 and CD28, leading to the activation of T cells
IN-VIVO
Interleukin-2 receptor subunit beta and gamma complex
TARGET->LIGAND
Related Record Type Details
GI-101
ACTIVE MOIETY
This is a non-substance concept
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966