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Details

Stereochemistry ACHIRAL
Molecular Formula C25H25N5O4
Molecular Weight 459.4971
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of APIXABAN

SMILES

COC1=CC=C(C=C1)N2N=C(C(N)=O)C3=C2C(=O)N(CC3)C4=CC=C(C=C4)N5CCCCC5=O

InChI

InChIKey=QNZCBYKSOIHPEH-UHFFFAOYSA-N
InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)

HIDE SMILES / InChI
Molecular Formula C25H25N5O4
Molecular Weight 459.4971
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:59:33 UTC 2023
Edited
by admin
on Fri Dec 15 15:59:33 UTC 2023
Record UNII
3Z9Y7UWC1J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
APIXABAN
DASH   EMA EPAR   INN   JAN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
APIXABAN [EMA EPAR]
Common Name English
APIXABAN [VANDF]
Common Name English
1-(4-METHOXYPHENYL)-7-OXO-6-(4-(2-OXOPIPERIDIN-1-YL)PHENYI)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO(3,4-C)PYRIDINE-3-CARBOXAMIDE
Common Name English
APIXABAN [JAN]
Common Name English
APIXABAN [MART.]
Common Name English
BMS-562247
Code English
APIXABAN [MI]
Common Name English
BMS-562247-01
Code English
Apixaban [WHO-DD]
Common Name English
APIXABAN [ORANGE BOOK]
Common Name English
1H-PYRAZOLO(3,4-C)PYRIDINE-3-CARBOXAMIDE, 4,5,6,7-TETRAHYDRO-1-( 4-METHOXYPHENYL)-7-OXO-6-(4-(2-OXO-1-PIPERIDINYL)PHENYL)-
Common Name English
ELIQUIS
Brand Name English
apixaban [INN]
Common Name English
APIXABAN [USAN]
Common Name English
Classification Tree Code System Code
LIVERTOX NBK548281
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
WHO-ATC B01AF02
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
NCI_THESAURUS C263
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
EMA ASSESSMENT REPORTS ELIQUIS (AUTHORIZED: ARTHROPLASTY)
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
LOINC 74214-8
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
WHO-VATC QB01AF02
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
EMA ASSESSMENT REPORTS ELIQUIS (AUTHORIZED: VENOUS THROMBOEMBOLISM)
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
NDF-RT N0000175637
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
Code System Code Type Description
SMS_ID
100000091294
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
IUPHAR
6390
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
FDA UNII
3Z9Y7UWC1J
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
EVMPD
SUB25425
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
INN
8626
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
JAPANESE REVIEW
ELIQUIS
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY APPROVED DECEMBER 2012
MESH
C522181
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
ChEMBL
CHEMBL231779
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
MERCK INDEX
m1993
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY Merck Index
CAS
503612-47-3
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
DAILYMED
3Z9Y7UWC1J
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
LACTMED
Apixaban
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
CHEBI
72296
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
HSDB
8223
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
PUBCHEM
10182969
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
WIKIPEDIA
APIXABAN
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
RXCUI
1364430
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY RxNorm
DRUG BANK
DB06605
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
USAN
QQ-78
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
NCI_THESAURUS
C61308
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
EPA CompTox
DTXSID80436500
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
DRUG CENTRAL
4298
Created by admin on Fri Dec 15 15:59:33 UTC 2023 , Edited by admin on Fri Dec 15 15:59:33 UTC 2023
PRIMARY
Related Record Type Details
Structure of APIXABAN
EXCRETED UNCHANGED
URINE
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
COAGULATION FACTOR X HUMAN
TARGET -> INHIBITOR
Ki
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
FACTOR XA
TARGET -> INHIBITOR
Structure of APIXABAN
EXCRETED UNCHANGED
FECAL
Related Record Type Details
Structure of O-DEMETHYL APIXABAN
METABOLITE -> PARENT
MINOR
Structure of O-DEMETHYL APIXABAN SULFATE
METABOLITE -> PARENT
MAJOR
PLASMA
Related Record Type Details
Structure of Ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
IMPURITY -> PARENT
Structure of 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
IMPURITY -> PARENT
Structure of Ethyl 6-[4-[(5-bromo-1-oxopentyl)amino]phenyl]-4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
IMPURITY -> PARENT
Structure of Apixaban acid
IMPURITY -> PARENT
Structure of Methyl 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
IMPURITY -> PARENT
Structure of Chloroapixaban
IMPURITY -> PARENT
Structure of Apixaban open ring amide
IMPURITY -> PARENT
Structure of Apixaban open ring acid
IMPURITY -> PARENT
Structure of Apixaban ethyl ester
IMPURITY -> PARENT
Structure of N-Formyl-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
IMPURITY -> PARENT
Structure of Ethyl 6-[4-(5-chloropentanamido)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
IMPURITY -> PARENT
Related Record Type Details
Structure of APIXABAN
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Tmax PHARMACOKINETIC ORAL ADMINISTRATION

Volume of Distribution PHARMACOKINETIC
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
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