U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C9H11NO4
Molecular Weight 197.1879
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LEVODOPA

SMILES

N[C@@H](CC1=CC(O)=C(O)C=C1)C(O)=O

InChI

InChIKey=WTDRDQBEARUVNC-LURJTMIESA-N
InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1

HIDE SMILES / InChI
Molecular Formula C9H11NO4
Molecular Weight 197.1879
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:02:45 UTC 2023
Edited
by admin
on Sat Dec 16 17:02:45 UTC 2023
Record UNII
46627O600J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LEVODOPA
EMA EPAR   EP   HSDB   INN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
INN   USAN  
Official Name English
LEVODOPA [JAN]
Common Name English
RYTARY COMPONENT LEVODOPA
Brand Name English
CARBILEV COMPONENT LEVODOPA
Common Name English
levodopa [INN]
Common Name English
LEVODOPA COMPONENT OF SINEMET
Common Name English
V-1512
Code English
LEVODOPA [WHO-IP]
Common Name English
LEVODOPA [ORANGE BOOK]
Common Name English
CORBILTA COMPONENT LEVODOPA
Brand Name English
LEVODOPA [EMA EPAR]
Common Name English
L-DOPA
Systematic Name English
LEVODOPA [USP-RS]
Common Name English
LEVODOPA COMPONENT OF DUOPA
Brand Name English
BENDOPA
Brand Name English
LEVODOPA COMPONENT OF STALEVO
Brand Name English
LEVODOPA [USAN]
Common Name English
LEVODOPA COMPONENT OF DOPASNAP
Common Name English
LEVODOPA [USP MONOGRAPH]
Common Name English
LEVODOPA/CARBIDOPA/ENTACAPONE ORION COMPONENT LEVODOPA
Brand Name English
LEVODOPA COMPONENT OF CORBILTA
Brand Name English
LEVODOPA [EP IMPURITY]
Common Name English
STALEVO COMPONENT LEVODOPA
Brand Name English
LEVODOPA COMPONENT OF PARCOPA
Common Name English
LARODOPA
Brand Name English
LEVODOPA COMPONENT OF LEVODOPA/CARBIDOPA/ENTACAPONE ORION
Brand Name English
IPX203 COMPONENT LEVODOPA
Common Name English
DOPAR
Brand Name English
DUOPA COMPONENT LEVODOPA
Brand Name English
PARCOPA COMPONENT LEVODOPA
Common Name English
LEVODOPA [HSDB]
Common Name English
LEVODOPA [EP MONOGRAPH]
Common Name English
IPX-203 COMPONENT LEVODOPA
Common Name English
LEVODOPA [MI]
Common Name English
LEVODOPA COMPONENT OF CARBILEV
Common Name English
DIHYDROXYPHENYLALANINE
Systematic Name English
NSC-118381
Code English
(-)-3-(3,4-DIHYDROXYPHENYL)-L-ALANINE
Systematic Name English
Levodopa [WHO-DD]
Common Name English
LEVODOPA COMPONENT OF DHIVY
Brand Name English
DHIVY COMPONENT LEVODOPA
Brand Name English
LEVODOPUM [WHO-IP LATIN]
Common Name English
LEVODOPA COMPONENT OF RYTARY
Brand Name English
L-TYROSINE, 3-HYDROXY-
Systematic Name English
DOPASNAP COMPONENT LEVODOPA
Common Name English
DOPA, L-
Systematic Name English
CVT-301
Common Name English
LEVODOPA [MART.]
Common Name English
INBRIJA
Brand Name English
LEVODOPA [VANDF]
Common Name English
Classification Tree Code System Code
WHO-VATC QN04BA03
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
DSLD 1198 (Number of products:24)
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
WHO-ESSENTIAL MEDICINES LIST 09 (LEV/CAR)
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
EMA ASSESSMENT REPORTS CORBILTA (AUTHORIZED: PARKINSON DISEASE)
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
EU-Orphan Drug EU/3/01/035
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
EMA ASSESSMENT REPORTS STALEVO (AUTHORIZED: PARKINSON DISEASE)
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
WHO-ATC N04BA01
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
EMA ASSESSMENT REPORTS CORBILTA (AUTHORIZED: NEURODEGENERATIVE DISEASES)
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
WHO-VATC QN04BA02
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
WHO-ATC N04BA03
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
WHO-VATC QN04BA01
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
LOINC 79577-3
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
NDF-RT N0000193220
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
LIVERTOX NBK548734
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
FDA ORPHAN DRUG 129499
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
NDF-RT N0000175754
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
WHO-ATC N04BA02
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
NCI_THESAURUS C66884
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
NDF-RT N0000175755
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
EMA ASSESSMENT REPORTS LEVODOPA/CARBIDOPA/ENTACAPONE ORION (AUTHORIZED: PARKINSON DISEASE)
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
EMA ASSESSMENT REPORTS CORBILTA (AUTHORIZED: NERVOUS SYSTEM DISEASES)
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
Code System Code Type Description
PUBCHEM
6047
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
WIKIPEDIA
L-DOPA
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
LACTMED
Levodopa
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
LEVODOPA
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY Description: A white or almost white, crystalline powder; odourless. Solubility: Soluble in 300 parts of water; practically insoluble in ethanol (~750 g/l) TS and ether R. Category: Antiparkinsonism drug. Storage: Levodopa should be kept in a tightly closed container.Definition: Levodopa contains not less than 98.5% and not more than 101.0% of C9H11NO4, calculated with reference to the dried substance.
MESH
D007980
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
DRUG CENTRAL
1567
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
NSC
118381
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
NCI_THESAURUS
C611
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
EVMPD
SUB08468MIG
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
EPA CompTox
DTXSID9023209
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
FDA UNII
46627O600J
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
ChEMBL
CHEMBL1009
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
DAILYMED
46627O600J
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
CHEBI
57504
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
HSDB
3348
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
SMS_ID
100000085446
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
CHEBI
15765
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
IUPHAR
3639
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
MERCK INDEX
m6786
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY Merck Index
INN
2651
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
ECHA (EC/EINECS)
200-445-2
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
CAS
59-92-7
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
RS_ITEM_NUM
1361009
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
DRUG BANK
DB01235
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY
RXCUI
6375
Created by admin on Sat Dec 16 17:02:48 UTC 2023 , Edited by admin on Sat Dec 16 17:02:48 UTC 2023
PRIMARY RxNorm
Related Record Type Details
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
CATECHOL O-METHYLTRANSFERASE
METABOLIC ENZYME -> SUBSTRATE
MUCUNA PRURIENS SEED
PARENT -> CONSTITUENT ALWAYS PRESENT
Structure of LEVODOPA
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
USP
Structure of LEVODOPA
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
EP
D(1A) DOPAMINE RECEPTOR
TARGET -> AGONIST
Related Record Type Details
Structure of ETILEVODOPA
PRODRUG -> METABOLITE ACTIVE
Structure of FOSLEVODOPA
PRODRUG -> METABOLITE ACTIVE
Structure of BISMUTH SUBDOPATE
PRODRUG -> METABOLITE ACTIVE
Structure of MELEVODOPA
PRODRUG -> METABOLITE ACTIVE
Structure of DOPAMINE
METABOLITE ACTIVE -> PRODRUG
Structure of DOPAMINE
METABOLITE ACTIVE -> PRODRUG
MAJOR
Structure of 3-O-METHYLDOPA
METABOLITE -> PARENT
When decarboxylation of levodopa is prevented by carbidopa, COMT becomes the major metabolizing enzyme for levodopa, catalyzing its metabolism to 3-methoxy-4-hydroxy-L-phenylalanine (3-OMD).
Structure of 3-HYDROXYBENZENEACETIC ACID
METABOLITE -> PARENT
Related Record Type Details
Structure of 3-O-METHYLDOPA, DL-
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of DOPA, D-
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 6-HYDROXYDOPA, L-
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 6-HYDROXYDOPA, DL-
PARENT -> IMPURITY
Structure of 6-HYDROXYDOPA, L-
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of TYROSINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of TYROSINE
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 2.2
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 3-O-METHYLDOPA, DL-
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 3,4-DIMETHOXYPHENYLALANINE, L-
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Related Record Type Details
Structure of LEVODOPA
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