OSELTAMIVIR PHOSPHATE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H28N2O4.H3O4P
Molecular Weight	410.3997
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of OSELTAMIVIR PHOSPHATE

Structure Search

SMILES

OP(O)(O)=O.CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1

InChI

InChIKey=PGZUMBJQJWIWGJ-ONAKXNSWSA-N

InChI=1S/C16H28N2O4.H3O4P/c1-5-12(6-2)22-14-9-11(16(20)21-7-3)8-13(17)15(14)18-10(4)19;1-5(2,3)4/h9,12-15H,5-8,17H2,1-4H3,(H,18,19);(H3,1,2,3,4)/t13-,14+,15+;/m0./s1

HIDE SMILES / InChI

Molecular Formula	H3O4P
Molecular Weight	97.9952
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C16H28N2O4
Molecular Weight	312.4045
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:25:33 UTC 2023` Edited by `admin` on `Fri Dec 15 16:25:33 UTC 2023`
Record UNII	4A3O49NGEZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OSELTAMIVIR PHOSPHATE

Official Name

English

OSELTAMIVIR (AS PHOSPHATE)

Common Name

English

TAMIFLU

Brand Name

English

OSELTAMIVIR PHOSPHATE [USP-RS]

Common Name

English

OSELTAMIVIR PHOSPHATE [JAN]

Common Name

English

OSELTAMIVIR PHOSPHATE [WHO-IP]

Common Name

English

AGUCORT

Brand Name

English

OSELTAMIVIR PHOSPHATE [MART.]

Common Name

English

OSELTAMIVIR PHOSPHATE [VANDF]

Common Name

English

OSELTAMIVIR PHOSPHATE [EP MONOGRAPH]

Common Name

English

ETHYL-(3R,4R,5S)-4-ACETAMIDO-5-AMINO-3-(1-ETHYLPROPOXY)-1-CYCLOHEXENE-1-CARBOXYLATE PHOSPHATE

Systematic Name

English

RO 64-0796/002

Code

English

RO-64-0796/002

Code

English

OSELTAMIVIR PHOSPHATE [MI]

Common Name

English

OSELTAMIVIR PHOSPHATE [USAN]

Common Name

English

OSELTAMIVIRI PHOSPHAS [WHO-IP LATIN]

Common Name

English

OSELTAMIVIR PHOSPHATE [USP MONOGRAPH]

Common Name

English

OSELTAMIVIR PHOSPHATE [USP IMPURITY]

Common Name

English

(3R-(3.ALPHA.,4.BETA.,5.ALPHA.))-ETHYL 4-(ACETYLAMINO)-5-AMINO-3-(1-ETHYLPROPOXY)-1-CYCLOHEXENE-1-CARBOXYLATE PHOSPHATE (1:1)

Common Name

English

OSELTAMIVIR PHOSPHATE [ORANGE BOOK]

Common Name

English

RO-64-0796-002

Code

English

Oseltamivir phosphate [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C281

Created by admin on Fri Dec 15 16:25:34 UTC 2023 , Edited by admin on Fri Dec 15 16:25:34 UTC 2023

Code System Code Type Description

EPA CompTox

DTXSID0044230

Created by admin on Fri Dec 15 16:25:34 UTC 2023 , Edited by admin on Fri Dec 15 16:25:34 UTC 2023

PRIMARY

EVMPD

SUB12544MIG

Created by admin on Fri Dec 15 16:25:34 UTC 2023 , Edited by admin on Fri Dec 15 16:25:34 UTC 2023

PRIMARY

MERCK INDEX

m8256

Created by admin on Fri Dec 15 16:25:34 UTC 2023 , Edited by admin on Fri Dec 15 16:25:34 UTC 2023

PRIMARY

Merck Index

USAN

KK-62

Created by admin on Fri Dec 15 16:25:34 UTC 2023 , Edited by admin on Fri Dec 15 16:25:34 UTC 2023

PRIMARY

NCI_THESAURUS

C29305

Created by admin on Fri Dec 15 16:25:34 UTC 2023 , Edited by admin on Fri Dec 15 16:25:34 UTC 2023

PRIMARY

RS_ITEM_NUM

1479304

Created by admin on Fri Dec 15 16:25:34 UTC 2023 , Edited by admin on Fri Dec 15 16:25:34 UTC 2023

PRIMARY

ChEMBL

CHEMBL1229

Created by admin on Fri Dec 15 16:25:34 UTC 2023 , Edited by admin on Fri Dec 15 16:25:34 UTC 2023

PRIMARY

FDA UNII

4A3O49NGEZ

Created by admin on Fri Dec 15 16:25:34 UTC 2023 , Edited by admin on Fri Dec 15 16:25:34 UTC 2023

PRIMARY

CHEBI

7799

Created by admin on Fri Dec 15 16:25:34 UTC 2023 , Edited by admin on Fri Dec 15 16:25:34 UTC 2023

PRIMARY

PUBCHEM

78000

Created by admin on Fri Dec 15 16:25:34 UTC 2023 , Edited by admin on Fri Dec 15 16:25:34 UTC 2023

PRIMARY

SMS_ID

100000091466

Created by admin on Fri Dec 15 16:25:34 UTC 2023 , Edited by admin on Fri Dec 15 16:25:34 UTC 2023

PRIMARY

DAILYMED

4A3O49NGEZ

Created by admin on Fri Dec 15 16:25:34 UTC 2023 , Edited by admin on Fri Dec 15 16:25:34 UTC 2023

PRIMARY

CAS

204255-11-8

Created by admin on Fri Dec 15 16:25:34 UTC 2023 , Edited by admin on Fri Dec 15 16:25:34 UTC 2023

PRIMARY

WHO INTERNATIONAL PHARMACOPEIA

OSELTAMIVIR PHOSPHATE

Created by admin on Fri Dec 15 16:25:34 UTC 2023 , Edited by admin on Fri Dec 15 16:25:34 UTC 2023

PRIMARY

Description: A white to off-white powder. Solubility: Freely soluble in water and in methanol. Category: Antiviral. Storage: Oseltamivir phosphate should be kept in a well-closed container, protected from light. Additional information: Oseltamivir phosphate may show polymorphism. Definition: Oseltamivir phosphate contains not less than 97.5% and not more than 102.0% of oseltamivir phosphate (C16H28N2O4, H3PO4) using Assay method A, and not less than 98.5% and not more than 101.0% of oseltamivir phosphate (C16H28N2O4, H3PO4) using Assay method B, both calculated with reference to the anhydrous substance.

RXCUI

259275

Created by admin on Fri Dec 15 16:25:34 UTC 2023 , Edited by admin on Fri Dec 15 16:25:34 UTC 2023

PRIMARY

RxNorm

CHEBI

7798

Created by admin on Fri Dec 15 16:25:34 UTC 2023 , Edited by admin on Fri Dec 15 16:25:34 UTC 2023

PRIMARY

DRUG BANK

DB00198

Created by admin on Fri Dec 15 16:25:34 UTC 2023 , Edited by admin on Fri Dec 15 16:25:34 UTC 2023

PRIMARY

Related Record Type Details


					4A3O49NGEZ

OSELTAMIVIR PHOSPHATE

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (HPLC)

Qualification:

USP

Amount:


					4A3O49NGEZ

OSELTAMIVIR PHOSPHATE

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (HPLC)

Qualification:

EP

Amount:


					20O93L6F9H

PARENT -> SALT/SOLVATE

Related Record Type Details


					300BX85SHX

4-N-DESACETYL-5-N-ACETYL OSELTAMIVIR

IMPURITY -> PARENT

Comments:

Use the chromatogram obtained with solution (4) to identify the peaks due to impurities A, B, C and D. The impurity peaks are eluted at the following relative retention with reference to oseltamivir phosphate (retention time about 19 minutes): impurity A about 0.16. The test is not valid unless the resolution between the peaks due to impurities A and B and that between the peaks due to impurities C and D is at least 1.3.


					3L23ELE4Y8

Ethyl (3R,4R,5S)-4-(acetylamino)-5-amino-3-(1-methylethoxy)-1-cyclohexene-1-carboxylate

IMPURITY -> PARENT

Amount:


					300BX85SHX

4-N-DESACETYL-5-N-ACETYL OSELTAMIVIR

IMPURITY -> PARENT

Comments:

UNSPECIFIED

Qualification:

EP


					79Q535BU4S

ETHYL 4-ACETAMIDO-3-HYDROXYBENZOATE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					10V6FRB9ME

4-N-DESACETYL-5-N-ACETYL OSELTAMIVIR ACID

IMPURITY -> PARENT

Comments:

UNSPECIFIED

Qualification:

EP


					797W095L6O

3-DES(1-ETHYLPROPOXY)-3-(1-METHYLPROPOXY) OSELTAMIVIR

IMPURITY -> PARENT

Comments:

UNSPECIFIED

Qualification:

EP


					IE8U85Q63A

2-AZIDO-1,2-DIHYDRO OSELTAMIVIR, (1R,2R)-

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					79Q535BU4S

ETHYL 4-ACETAMIDO-3-HYDROXYBENZOATE

IMPURITY -> PARENT

Comments:

Use the chromatogram obtained with solution (4) to identify the peaks due to impurities A, B, C and D. The impurity peaks are eluted at the following relative retention with reference to oseltamivir phosphate (retention time about 19 minutes): impurity C about 0.51. The test is not valid unless the resolution between the peaks due to impurities A and B and that between the peaks due to impurities C and D is at least 1.3.


					K6106LV5Q8

OSELTAMIVIR ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					IE8U85Q63A

2-AZIDO-1,2-DIHYDRO OSELTAMIVIR, (1R,2R)-

IMPURITY -> PARENT

Comments:

Use the chromatogram obtained with solution (4) to identify the peaks due to impurities A, B, C and D. The impurity peaks are eluted at the following relative retention with reference to oseltamivir phosphate (retention time about 19 minutes): impurity B about 0.17. The test is not valid unless the resolution between the peaks due to impurities A and B and that between the peaks due to impurities C and D is at least 1.3.


					79Q535BU4S

ETHYL 4-ACETAMIDO-3-HYDROXYBENZOATE

IMPURITY -> PARENT

Comments:

UNSPECIFIED

Qualification:

EP


					VA6M0DID7C

OSELTAMIVIR ACID METHYL ESTER

IMPURITY -> PARENT

Comments:

Use the chromatogram obtained with solution (4) to identify the peaks due to impurities A, B, C and D. The impurity peaks are eluted at the following relative retention with reference to oseltamivir phosphate (retention time about 19 minutes): impurity D about 0.55. The test is not valid unless the resolution between the peaks due to impurities A and B and that between the peaks due to impurities C and D is at least 1.3.


					VA6M0DID7C

OSELTAMIVIR ACID METHYL ESTER

IMPURITY -> PARENT

Comments:

UNSPECIFIED

Qualification:

EP


					K6106LV5Q8

OSELTAMIVIR ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					W58CDF8S4H

BUTYPHOS

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (GC)

Qualification:

EP

Amount:

Related Record Type Details


					K6106LV5Q8

OSELTAMIVIR ACID

ACTIVE MOIETY